Erschienen in:
01.06.2013 | Original Article
The relationship between urinary bisphenol A levels and meningioma in Chinese adults
verfasst von:
Bo Duan, Xuebin Hu, Hongyang Zhao, Jun Qin, Jie Luo
Erschienen in:
International Journal of Clinical Oncology
|
Ausgabe 3/2013
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Abstract
Background
Estrogen has been implicated as a risk factor for meningioma. Bisphenol A (BPA), a widely used synthetic xenoestrogen, has already been reported to be associated with several estrogen-sensitive tumors.
Method
An exploratory association study of 243 meningioma cases and 258 frequency-matched healthy controls was conducted, using subjects from a hospital-based study to demonstrate the association of urine BPA concentration and the risk of meningioma. The specimens and data of patients were collected at Union Hospital, Wuhan, China, from 2009 to 2010.
Results
A positive association between increasing levels of urinary BPA and meningioma was observed, independent of confounding factors such as gender, age, race, body mass index, HRT use, BMI, and family history of cancer. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio of meningioma associated with quartile 4 was 1.45 (95 % CI, 1.02–1.98) (P trend = 0.03).
Conclusion
In this case–control study from China, a clear association between urinary BPA concentrations and diagnosis of meningioma was detected.