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Heart Failure Reviews

Erschienen in:

11.09.2019

The renin-angiotensin-aldosterone system: a crossroad from arterial hypertension to heart failure

verfasst von: Nicola Riccardo Pugliese, Stefano Masi, Stefano Taddei

Erschienen in: Heart Failure Reviews | Ausgabe 1/2020

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Abstract

The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of blood pressure and volume homeostasis, promoting critical structural changes in every component of the cardiovascular system, including the heart and blood vessels. Consequently, the RAAS is a crucial therapeutic target for several chronic diseases of the cardiovascular system, spanning from arterial hypertension (AH) to heart failure (HF). AH represents a leading risk factor for the development of symptomatic HF, particularly with left ventricle (LV) preserved ejection fraction (HFpEF). LV diastolic dysfunction and cardiac remodelling are the first discernible manifestations of heart disease in patients with AH. Typically, AH develops many years before the diagnosis of overt HF, providing a therapeutic target for preventive strategies. Treatment of AH is based on different classes of antihypertensive drugs, which show differences in their capacity to prevent the evolution towards HF. The blockers of the RAAS are effective drugs to treat AH and prevent HF with reduced ejection fraction (HFrEF), but the evidence of the potential benefits in patients with HFpEF remains limited. In this review, the authors summarise data from several clinical trials of HFpEF and HFrEF, focusing on the mechanisms leading the transition from AH to HF and late complications.

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Titel: The renin-angiotensin-aldosterone system: a crossroad from arterial hypertension to heart failure
verfasst von: Nicola Riccardo Pugliese
Stefano Masi
Stefano Taddei
Publikationsdatum: 11.09.2019
Verlag: Springer US
Erschienen in: Heart Failure Reviews / Ausgabe 1/2020
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-019-09855-5

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The renin-angiotensin-aldosterone system: a crossroad from arterial hypertension to heart failure

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