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Current Atherosclerosis Reports

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01.05.2014 | Coronary Heart Disease (JA Farmer, Section Editor)

The Role of Nonpharmacologic Device Interventions in the Management of Drug-Resistant Hypertension

verfasst von: William H. Frishman, Daniel Glicklich

Erschienen in: Current Atherosclerosis Reports | Ausgabe 5/2014

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Abstract

Resistant systemic hypertension in patients is defined as the inability to control blood pressure despite taking at least three antihypertensive drugs, one of which is a diuretic. Two nonpharmacologic approaches are being evaluated in resistant hypertensive patients. First, the Rheos® Baroreflex Hypertension Therapy system is an implantable device that activates the carotid baroreflex through electrical stimulation of the carotid sinus wall. Sustained and clinically lower blood pressure has been observed in patient clinical trials. The second approach is a catheter-based strategy which denervates the renal afferent and efferent autonomic nervous system. This strategy has also been shown to be effective in drug-resistant patients, and has also been shown to decrease renin production, preserve renal function, improve glucose tolerance, and reduce left ventricular hypertrophy. Both carotid sinus stimulation and renal denervation are now being evaluated in clinical trials for the long-term control of hypertension.

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Titel: The Role of Nonpharmacologic Device Interventions in the Management of Drug-Resistant Hypertension
verfasst von: William H. Frishman
Daniel Glicklich
Publikationsdatum: 01.05.2014
Verlag: Springer US
Erschienen in: Current Atherosclerosis Reports / Ausgabe 5/2014
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-014-0405-5

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