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Current Hypertension Reports

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01.02.2013 | Hypertension and the Kidney (RM Carey and A Mimran, Section Editors)

The Role of Type 1 Angiotensin Receptors on T Lymphocytes in Cardiovascular and Renal Diseases

verfasst von: Jiandong Zhang, Steven D. Crowley

Erschienen in: Current Hypertension Reports | Ausgabe 1/2013

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Abstract

The renin–angiotensin system plays a critical role in the pathogenesis of several cardiovascular diseases, largely through activation of type I angiotensin (AT₁) receptors by angiotensin II. Treatment with AT₁ receptor blockers (ARBs) is a proven successful intervention for hypertension and progressive heart and kidney disease. However, the divergent actions of AT₁ receptors on individual cell lineages in hypertension may present novel opportunities to optimize the therapeutic benefits of ARBs. For example, T lymphocytes make important contributions to the induction and progression of various cardiovascular diseases, but new experiments indicate that activation of AT₁ receptors on T cells paradoxically limits inflammation and target organ damage in hypertension. Future studies should illustrate how these discrepant functions of AT₁ receptors in target organs versus mononuclear cells can be exploited for the benefit of patients with recalcitrant hypertension and other cardiovascular diseases.

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Titel: The Role of Type 1 Angiotensin Receptors on T Lymphocytes in Cardiovascular and Renal Diseases
verfasst von: Jiandong Zhang
Steven D. Crowley
Publikationsdatum: 01.02.2013
Verlag: Current Science Inc.
Erschienen in: Current Hypertension Reports / Ausgabe 1/2013
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-012-0318-z

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