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Journal of Cancer Research and Clinical Oncology

Erschienen in:

16.08.2018 | Review – Cancer Research

The roles of PKCs in regulating autophagy

verfasst von: Tianyi Wang, Conghe Liu, Lili Jia

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 12/2018

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Abstract

Purpose

Autophagy, as a highly conserved cellular degradation and recycling process, plays an important part in maintaining cellular homeostasis. PKC signaling is involved in multiple pathways including cell cycle progression, tumorigenesis, migration and autophagy.

Methods

Literatures about PKC and autophagy from PubMed databases were reviewed in this study.

Results

Studies regarding the association of PKC and autophagy remain debatable. Different duration of the stimulation of autophagy and distinct cell contexts result in different function of PKC in regulating autophagy. The subcellular localization of PKCs and their downstream regulators may influence the autophagy regulation as well. As important intracellular components, the mitochondria play an important role in regulating autophagy, by metabolic modulation and structural derangement.

Conclusion

Phase II studies regarding PKC-β inhibitor, enzastaurin, showed promising results in MCL, DLBCL and recurrent high-grade gliomas. However, the detailed mechanism is still in need. The mechanism of PKC-β in mediating autophagy in lymphoma and high-grade gliomas remains elusive as well. Moreover, several studies were in agreement that rottlerin enhanced autophagy in breast cancer cells, which warrants further clinical studies to verify PKC-δ as a therapeutic target. Thus, identifying the function of PKC in modulating autophagy and conducting related clinical studies help find novel target for chemotherapy.

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Titel: The roles of PKCs in regulating autophagy
verfasst von: Tianyi Wang
Conghe Liu
Lili Jia
Publikationsdatum: 16.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 12/2018
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-018-2731-4

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The roles of PKCs in regulating autophagy

Abstract

Purpose

Methods

Results

Conclusion

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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