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Tumor Biology

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01.04.2014 | Research Article

The Val158Met polymorphism in the COMT gene is associated with increased cancer risks in Chinese population

verfasst von: Can Tian, Liping Liu, Xiaohong Yang, Hui Wu, Quchang Ouyang

Erschienen in: Tumor Biology | Ausgabe 4/2014

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Abstract

The Val158Met polymorphism in the COMT gene may affect the DNA repair pathways and be associated with the risk of cancer in Chinese population. However, the results of previous studies are inconsistent. The objective of this study was to investigate the association between the Val158Met polymorphism in the COMT gene and the risk of cancer for Chinese population by meta-analysis. We searched PubMed, Embase, CNKI, Weipu, and Wanfang databases, and the last search was updated on Sep. 26, 2013. Statistical analysis was performed using the Revman4.2 and Stata10.0 software. A total of 18 case–control studies concerning 5034 case and 6234 controls were included. In the total analysis, the results suggested a significant association between the Val158Met polymorphism in the COMT gene and the cancer risk in Chinese population: OR = 1.34, 95 %CI = 1.04–1.73, and P = 0.03 for AA vs. AG + GG; OR = 1.39, 95 %CI = 1.06–1.82, and P = 0.02; OR = 1.13, 95 %CI = 1.01–1.27, and P = 0.04. In the subgroup analysis by cancer types, significant association was found in the breast cancer and esophageal squamous cell carcinoma. The current meta-analysis confirmed that the Val158Met polymorphism in the COMT gene may be a risk factor for cancer in Chinese population. In the future, more case–control studies are needed to validate our results.

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Titel: The Val158Met polymorphism in the COMT gene is associated with increased cancer risks in Chinese population
verfasst von: Can Tian
Liping Liu
Xiaohong Yang
Hui Wu
Quchang Ouyang
Publikationsdatum: 01.04.2014
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 4/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-013-1387-6

Springer Medizin

The Val158Met polymorphism in the COMT gene is associated with increased cancer risks in Chinese population

Abstract

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Springer Medizin

Abstract

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