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Erschienen in: Anatomical Science International 1/2020

10.08.2019 | Original Article

Three-dimensional geometric morphometric analysis of tooth shape in hypodontia: II size variation

verfasst von: Ibrahim AlShahrani

Erschienen in: Anatomical Science International | Ausgabe 1/2020

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Abstract

The study aimed to evaluate differences in tooth size between patients with hypodontia and those with normal complement of permanent teeth using three-dimensional geometric morphometric analysis. The number of anatomical landmarks was recorded on the clinical crown of the permanent teeth on three-dimensional scanned study models of hypodontia and in control subjects. The study sample comprised 120 patients with hypodontia (mild, moderate, severe) and 40 controls matched for age and sex. Tooth size differences were tested statistically using multivariate statistics. Size variation was for the most part found to be significant, especially when the control subjects were compared with the hypodontia groups. The explained variance among group membership was generally larger in the anterior and premolar region than in the molar region Sexual dimorphism was found less in the anterior region than in the posterior region; therefore, the sexes were pooled more often for teeth in the anterior region. Quantitative measurement of tooth size in patients with hypodontia may enhance the multidisciplinary management of these patients.
Literatur
Zurück zum Zitat AlShahrani I, Dirks W, Jepson N, Khalaf K (2014) 3D Geomorphometrics tooth shape analysis in hypodontia. Front Physiol 5:154 AlShahrani I, Dirks W, Jepson N, Khalaf K (2014) 3D Geomorphometrics tooth shape analysis in hypodontia. Front Physiol 5:154
Zurück zum Zitat Alvesalo L, Portin P (1969) The inheritance pattern of missing, PEG-shaped, and strongly mesio-distally reduced upper lateral incisors. Acta Odontol Scand 27:563–575PubMed Alvesalo L, Portin P (1969) The inheritance pattern of missing, PEG-shaped, and strongly mesio-distally reduced upper lateral incisors. Acta Odontol Scand 27:563–575PubMed
Zurück zum Zitat Axelsson G, Kirveskari P (1983) Crown size of permanent teeth in Icelanders. Acta Odontol Scand 41:181–186PubMed Axelsson G, Kirveskari P (1983) Crown size of permanent teeth in Icelanders. Acta Odontol Scand 41:181–186PubMed
Zurück zum Zitat Bailit HL (1975) Dental variation among populations. An anthropologic view. Dent Clin N Am 19:125–139PubMed Bailit HL (1975) Dental variation among populations. An anthropologic view. Dent Clin N Am 19:125–139PubMed
Zurück zum Zitat Baum BJ, Cohen MM (1971) Agenesis and tooth size in the permanent dentition. Angle Orthod 41:100–102PubMed Baum BJ, Cohen MM (1971) Agenesis and tooth size in the permanent dentition. Angle Orthod 41:100–102PubMed
Zurück zum Zitat Baum BJ, Cohen MM (1971) Patterns of size reduction in hypodontia. J Dent Res 50:779PubMed Baum BJ, Cohen MM (1971) Patterns of size reduction in hypodontia. J Dent Res 50:779PubMed
Zurück zum Zitat Baum BJ, Cohen MM (1971) Studies on agenesis in the permanent dentition. Am J Phys Anthrop 35:125–128PubMed Baum BJ, Cohen MM (1971) Studies on agenesis in the permanent dentition. Am J Phys Anthrop 35:125–128PubMed
Zurück zum Zitat Bernal V (2007) Size and shape analysis of human molars: comparing traditional and geometric morphometric techniques. Homo 58:279–296PubMed Bernal V (2007) Size and shape analysis of human molars: comparing traditional and geometric morphometric techniques. Homo 58:279–296PubMed
Zurück zum Zitat Brook AH (1984) A unifying aetiological explanation for anomalies of human tooth number and size. Arch Oral Biol 29:373–378PubMed Brook AH (1984) A unifying aetiological explanation for anomalies of human tooth number and size. Arch Oral Biol 29:373–378PubMed
Zurück zum Zitat Brook AH (2009) Multilevel complex interactions between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development. Arch Oral Biol 54(Suppl 1):S3–S17PubMedPubMedCentral Brook AH (2009) Multilevel complex interactions between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development. Arch Oral Biol 54(Suppl 1):S3–S17PubMedPubMedCentral
Zurück zum Zitat Brook AH, Elcock C, Al-Sharood MH, McKeown HF, Khalaf K, Smith RN (2002) Further studies of a model for the etiology of anomalies of tooth number and size in humans. Connect Tissue Res 43:289–295PubMed Brook AH, Elcock C, Al-Sharood MH, McKeown HF, Khalaf K, Smith RN (2002) Further studies of a model for the etiology of anomalies of tooth number and size in humans. Connect Tissue Res 43:289–295PubMed
Zurück zum Zitat Brook AH, Elcock C, Aggarwal M et al (2009) Tooth dimensions in hypodontia with a known PAX9 mutation. Arch Oral Biol 54(Supp 1):S57–S62PubMed Brook AH, Elcock C, Aggarwal M et al (2009) Tooth dimensions in hypodontia with a known PAX9 mutation. Arch Oral Biol 54(Supp 1):S57–S62PubMed
Zurück zum Zitat Brook AH, Griffin RC, Smith RN et al (2009) Tooth size patterns in patients with hypodontia and supernumerary teeth. Arch Oral Biol 54(Suppl 1):S63–S70PubMed Brook AH, Griffin RC, Smith RN et al (2009) Tooth size patterns in patients with hypodontia and supernumerary teeth. Arch Oral Biol 54(Suppl 1):S63–S70PubMed
Zurück zum Zitat Brook AH, Griffin RC, Townsend G, Levisianos Y, Russell J, Smith RN (2009) Variability and patterning in permanent tooth size of four human ethnic groups. Arch Oral Biol 54(Suppl 1):S79–85PubMed Brook AH, Griffin RC, Townsend G, Levisianos Y, Russell J, Smith RN (2009) Variability and patterning in permanent tooth size of four human ethnic groups. Arch Oral Biol 54(Suppl 1):S79–85PubMed
Zurück zum Zitat Butler PM (1939) Studies of the mammalian dentition.– differentiation of the post canine dentition. Proc Zool Soc Lond 109:1–36 Butler PM (1939) Studies of the mammalian dentition.– differentiation of the post canine dentition. Proc Zool Soc Lond 109:1–36
Zurück zum Zitat Cignoni P, Corsini M, Ranzuglia G (2008) MeshLab: an open-source 3D mesh processing system. ERCIM News 73:45–46 Cignoni P, Corsini M, Ranzuglia G (2008) MeshLab: an open-source 3D mesh processing system. ERCIM News 73:45–46
Zurück zum Zitat Dahlberg AA (1945) The changing dentition of man. J Am Dent Assoc 32:676–690 Dahlberg AA (1945) The changing dentition of man. J Am Dent Assoc 32:676–690
Zurück zum Zitat Garn SM, Lewis AB (1970) The gradient and the pattern of crown-size reduction in simple hypodontia. Angle Orthod 40:51–58PubMed Garn SM, Lewis AB (1970) The gradient and the pattern of crown-size reduction in simple hypodontia. Angle Orthod 40:51–58PubMed
Zurück zum Zitat Garn SM, Lewis AB, Swindler DR, Kerewsky RS (1967) Genetic control of sexual dimorphism in tooth size. J Dent Res 46:963–972PubMed Garn SM, Lewis AB, Swindler DR, Kerewsky RS (1967) Genetic control of sexual dimorphism in tooth size. J Dent Res 46:963–972PubMed
Zurück zum Zitat Garn SM, Osborne RH, Alvesalo L, Horowitz SL (1980) Maternal and gestational influences on deciduous and permanent tooth size. J Dent Res 59:142–143PubMed Garn SM, Osborne RH, Alvesalo L, Horowitz SL (1980) Maternal and gestational influences on deciduous and permanent tooth size. J Dent Res 59:142–143PubMed
Zurück zum Zitat Gomez-Robles A, Martinon-Torres M, Bermudez de Castro JM et al (2007) A geometric morphometric analysis of hominin upper first molar shape. J Hum Evol 53:272–285PubMed Gomez-Robles A, Martinon-Torres M, Bermudez de Castro JM et al (2007) A geometric morphometric analysis of hominin upper first molar shape. J Hum Evol 53:272–285PubMed
Zurück zum Zitat Gomez-Robles A, Martinon-Torres M, Bermudez de Castro JM, Prado L, Sarmiento S, Arsuaga JL (2008) Geometric morphometric analysis of the crown morphology of the lower first premolar of hominins, with special attention to Pleistocene Homo. J Hum Evol 55:627–638PubMed Gomez-Robles A, Martinon-Torres M, Bermudez de Castro JM, Prado L, Sarmiento S, Arsuaga JL (2008) Geometric morphometric analysis of the crown morphology of the lower first premolar of hominins, with special attention to Pleistocene Homo. J Hum Evol 55:627–638PubMed
Zurück zum Zitat Grahnen H (1956) Hypodontia in the permanent dentition: a clinical and genetic investigation. Gleerup, Malmo, pp 1–100 Grahnen H (1956) Hypodontia in the permanent dentition: a clinical and genetic investigation. Gleerup, Malmo, pp 1–100
Zurück zum Zitat Hammer Ø, Harper DAT, Ryan PD (2001) PAST: paleontological statistics software package for education and data analysis. Palaeontol Electr 4:9 Hammer Ø, Harper DAT, Ryan PD (2001) PAST: paleontological statistics software package for education and data analysis. Palaeontol Electr 4:9
Zurück zum Zitat Harris EF (2003) Where's the variation? Variance components in tooth sizes of the permanent dentition. Dent Anthropol 16:84–94 Harris EF (2003) Where's the variation? Variance components in tooth sizes of the permanent dentition. Dent Anthropol 16:84–94
Zurück zum Zitat Harris EF, Bailit HL (1988) A principal components analysis of human odontometrics. Am J Phys Anthropol 75:87–99PubMed Harris EF, Bailit HL (1988) A principal components analysis of human odontometrics. Am J Phys Anthropol 75:87–99PubMed
Zurück zum Zitat Harris EF, Rathbun TA (1991) Ethnic differences in the apportionment of tooth sizes. Adv Dent Anthropol 3:121–142 Harris EF, Rathbun TA (1991) Ethnic differences in the apportionment of tooth sizes. Adv Dent Anthropol 3:121–142
Zurück zum Zitat Hillson S (1996) Dental anthropology. Cambridge University Press, Cambridge Hillson S (1996) Dental anthropology. Cambridge University Press, Cambridge
Zurück zum Zitat Kangas AT, Evans AR, Thesleff I, Jernvall J (2004) Nonindependence of mammalian dental characters. Nature 432:211–214PubMed Kangas AT, Evans AR, Thesleff I, Jernvall J (2004) Nonindependence of mammalian dental characters. Nature 432:211–214PubMed
Zurück zum Zitat Kendall DG (1977) The diffusion of shape. Adv Appl Probab 9:428–430 Kendall DG (1977) The diffusion of shape. Adv Appl Probab 9:428–430
Zurück zum Zitat Khalaf K, Robinson DL, Elcock C, Smith RN, Brook AH (2005) Tooth size in patients with supernumerary teeth and a control group measured by image analysis system. Arch Oral Biol. 50:243–248PubMed Khalaf K, Robinson DL, Elcock C, Smith RN, Brook AH (2005) Tooth size in patients with supernumerary teeth and a control group measured by image analysis system. Arch Oral Biol. 50:243–248PubMed
Zurück zum Zitat Khalaf K, Smith RN, Elcock C, Brook AH (2009) Multiple crown size variables of the upper incisors in patients with supernumerary teeth compared with controls. Arch Oral Biol 54(Suppl 1):S71–S78PubMed Khalaf K, Smith RN, Elcock C, Brook AH (2009) Multiple crown size variables of the upper incisors in patients with supernumerary teeth compared with controls. Arch Oral Biol 54(Suppl 1):S71–S78PubMed
Zurück zum Zitat Kieser JA, Groeneveld HT, Preston CB (1985) A metric analysis of the South African Caucasoid dentition. J Dent Assoc S Afr 40:121–125PubMed Kieser JA, Groeneveld HT, Preston CB (1985) A metric analysis of the South African Caucasoid dentition. J Dent Assoc S Afr 40:121–125PubMed
Zurück zum Zitat Klingenberg CP (2011) MorphoJ: an integrated software package for geometric morphometrics. Mol Ecol Resour 11:353–357PubMed Klingenberg CP (2011) MorphoJ: an integrated software package for geometric morphometrics. Mol Ecol Resour 11:353–357PubMed
Zurück zum Zitat Kondo S, Townsend GC (2006) Associations between Carabelli trait and cusp areas in human permanent maxillary first molars. Am J Phys Anthropol 129:196–203PubMed Kondo S, Townsend GC (2006) Associations between Carabelli trait and cusp areas in human permanent maxillary first molars. Am J Phys Anthropol 129:196–203PubMed
Zurück zum Zitat Lavelle CLB (1970) Analysis of attrition in adult human molars. J Dent Res 49:822–828PubMed Lavelle CLB (1970) Analysis of attrition in adult human molars. J Dent Res 49:822–828PubMed
Zurück zum Zitat Lavelle CL (1972) Morphological variations between English population samples. J Dent 1(1):47–52PubMed Lavelle CL (1972) Morphological variations between English population samples. J Dent 1(1):47–52PubMed
Zurück zum Zitat Lavelle CL (1975) Dental and other bodily dimensions in different orthodontic categories. Angle Orthod 45:65–71PubMed Lavelle CL (1975) Dental and other bodily dimensions in different orthodontic categories. Angle Orthod 45:65–71PubMed
Zurück zum Zitat McCollum MA, Sharpe PT (2001) Developmental genetics and early hominid craniodental evolution. BioEssays 23:481–493PubMed McCollum MA, Sharpe PT (2001) Developmental genetics and early hominid craniodental evolution. BioEssays 23:481–493PubMed
Zurück zum Zitat McKeown HF, Robinson DL, Elcock C, Al-Sharood M, Brook AH (2002) Tooth dimensions in patients with hypodontia, their unaffected relatives and a control group measured by a new image analysis system. Eur J Orthod 24:131–141PubMed McKeown HF, Robinson DL, Elcock C, Al-Sharood M, Brook AH (2002) Tooth dimensions in patients with hypodontia, their unaffected relatives and a control group measured by a new image analysis system. Eur J Orthod 24:131–141PubMed
Zurück zum Zitat Mirabella AD, Kokich VG, Rosa M (2011) Analysis of crown widths in subjects with congenitally missing maxillary lateral incisors. Eur J Orthod 34:783–787PubMed Mirabella AD, Kokich VG, Rosa M (2011) Analysis of crown widths in subjects with congenitally missing maxillary lateral incisors. Eur J Orthod 34:783–787PubMed
Zurück zum Zitat Miyabara T (1915) An anthropological study of the masticatory system in the Japanese. Dent Cosmos 58:739–749 Miyabara T (1915) An anthropological study of the masticatory system in the Japanese. Dent Cosmos 58:739–749
Zurück zum Zitat Moorrees CF, Jensen E, Kai-Jen Yen P, Thomsen SO (1957) Mesiodistal crown diameters of the deciduous and permanent teeth in individuals. J Dent Res 36:39–47PubMed Moorrees CF, Jensen E, Kai-Jen Yen P, Thomsen SO (1957) Mesiodistal crown diameters of the deciduous and permanent teeth in individuals. J Dent Res 36:39–47PubMed
Zurück zum Zitat Ooshima T, Sugiyama K, Sobue S (1988) Oligodontia in the primary dentition with permanent successors: report of case. ASDC J Dent Child 55:75–77PubMed Ooshima T, Sugiyama K, Sobue S (1988) Oligodontia in the primary dentition with permanent successors: report of case. ASDC J Dent Child 55:75–77PubMed
Zurück zum Zitat Ooshima T, Ishida R, Mishima K, Sobue S (1996) The prevalence of developmental anomalies of teeth and their association with tooth size in the primary and permanent dentitions of 1650 Japanese children. Int J Paediatr Dent 6:87–94PubMed Ooshima T, Ishida R, Mishima K, Sobue S (1996) The prevalence of developmental anomalies of teeth and their association with tooth size in the primary and permanent dentitions of 1650 Japanese children. Int J Paediatr Dent 6:87–94PubMed
Zurück zum Zitat Pallant J (2007) SPSS survival manual. Open University Press, Berkshire, UK Pallant J (2007) SPSS survival manual. Open University Press, Berkshire, UK
Zurück zum Zitat Peck S, Peck H (1975) Othodontic aspects of dental anthropology. Angle Orthod 45:95PubMed Peck S, Peck H (1975) Othodontic aspects of dental anthropology. Angle Orthod 45:95PubMed
Zurück zum Zitat Perzigian AJ (1976) The dentition of the Indian Knoll skeletal population: odontometrics and cusp number. Am J Phys Anthropol 44:113–121PubMed Perzigian AJ (1976) The dentition of the Indian Knoll skeletal population: odontometrics and cusp number. Am J Phys Anthropol 44:113–121PubMed
Zurück zum Zitat Pinkerton S, Townsend GC, Richards LY, Schwerdt W, Dempsey P (1999) Expression of Carabelli trait in both dentitions of Australian twins. Perspec Hum Biol 4:19–28 Pinkerton S, Townsend GC, Richards LY, Schwerdt W, Dempsey P (1999) Expression of Carabelli trait in both dentitions of Australian twins. Perspec Hum Biol 4:19–28
Zurück zum Zitat Potter RH, Nance WE (1976) A twin study of dental dimension. I. Discordance, asymmetry, and mirror imagery. Am J Phys Anthropol 44:391–395PubMed Potter RH, Nance WE (1976) A twin study of dental dimension. I. Discordance, asymmetry, and mirror imagery. Am J Phys Anthropol 44:391–395PubMed
Zurück zum Zitat Potter RH, Alcazaren AB, Herbosa FM, Tomaneng J (1981) Dimensional characteristics of the Filipino dentition. Am J Phys Anthropol 55:33–42PubMed Potter RH, Alcazaren AB, Herbosa FM, Tomaneng J (1981) Dimensional characteristics of the Filipino dentition. Am J Phys Anthropol 55:33–42PubMed
Zurück zum Zitat Rantanen AV (1956) On the frequency of the missing and pegshaped maxillary lateral incisor among Finnish students. Am J Phys Anthropol. 14:491–496PubMed Rantanen AV (1956) On the frequency of the missing and pegshaped maxillary lateral incisor among Finnish students. Am J Phys Anthropol. 14:491–496PubMed
Zurück zum Zitat Richardson ER, Malhotra SK (1975) Mesiodistal crown dimension of the permanent dentition of American Negroes. Am J Orthod 68:157–164PubMed Richardson ER, Malhotra SK (1975) Mesiodistal crown dimension of the permanent dentition of American Negroes. Am J Orthod 68:157–164PubMed
Zurück zum Zitat Robinson DL, Blackwell PG, Stillman EC, Brook AH (2001) Planar Procrustes analysis of tooth shape. Arch Oral Biol 46:191–199PubMed Robinson DL, Blackwell PG, Stillman EC, Brook AH (2001) Planar Procrustes analysis of tooth shape. Arch Oral Biol 46:191–199PubMed
Zurück zum Zitat Rune B, Sarnas KV (1974) Tooth size and tooth formation in children with advanced hypodontia. Angle Orthod. 44:316–321PubMed Rune B, Sarnas KV (1974) Tooth size and tooth formation in children with advanced hypodontia. Angle Orthod. 44:316–321PubMed
Zurück zum Zitat Schalk-van der Weide Y, Bosman F (1996) Tooth size in relatives of individuals with oligodontia. Arch Oral Biol 41:469–472PubMed Schalk-van der Weide Y, Bosman F (1996) Tooth size in relatives of individuals with oligodontia. Arch Oral Biol 41:469–472PubMed
Zurück zum Zitat Tan SP, Van Wijk AJ, Prahl-Andersen B (2011) Severe hypodontia: identifying patterns of human tooth agenesis. Eur J Orthod 33:150PubMed Tan SP, Van Wijk AJ, Prahl-Andersen B (2011) Severe hypodontia: identifying patterns of human tooth agenesis. Eur J Orthod 33:150PubMed
Zurück zum Zitat Townsend GC, Martin NG (1992) Fitting genetic models to Carabelli trait data in South Australian twins. J Dent Res 71:403–409PubMed Townsend GC, Martin NG (1992) Fitting genetic models to Carabelli trait data in South Australian twins. J Dent Res 71:403–409PubMed
Zurück zum Zitat Townsend G, Harris EF, Lesot H, Clauss F, Brook A (2009) Morphogenetic fields within the human dentition: a new, clinically relevant synthesis of an old concept. Arch Oral Biol 54:S34–S44PubMedPubMedCentral Townsend G, Harris EF, Lesot H, Clauss F, Brook A (2009) Morphogenetic fields within the human dentition: a new, clinically relevant synthesis of an old concept. Arch Oral Biol 54:S34–S44PubMedPubMedCentral
Zurück zum Zitat Townsend G, Hughes T, Luciano M, Bockmann M, Brook A (2009) Genetic and environmental influences on human dental variation: a critical evaluation of studies involving twins. Arch Oral Biol 54:S45–S51PubMedPubMedCentral Townsend G, Hughes T, Luciano M, Bockmann M, Brook A (2009) Genetic and environmental influences on human dental variation: a critical evaluation of studies involving twins. Arch Oral Biol 54:S45–S51PubMedPubMedCentral
Zurück zum Zitat Townsend G, Bockmann M, Hughes T, Brook A (2011) Genetic, environmental and epigenetic influences on variation in human tooth number, size and shape. Odontology 10:1–9 Townsend G, Bockmann M, Hughes T, Brook A (2011) Genetic, environmental and epigenetic influences on variation in human tooth number, size and shape. Odontology 10:1–9
Zurück zum Zitat Vastardis H (2000) The genetics of human tooth agenesis: new discoveries for understanding dental anomalies. Am J Orthod Dentofac Orthop 117:650–656 Vastardis H (2000) The genetics of human tooth agenesis: new discoveries for understanding dental anomalies. Am J Orthod Dentofac Orthop 117:650–656
Zurück zum Zitat Wiley DF, Amenta N, Alcantara DA, Ghosh D, Kil YJ, Delson E et al (2005) Evolutionary morphing. In: Proceedings of the IEEE visualization, pp 431–438 Wiley DF, Amenta N, Alcantara DA, Ghosh D, Kil YJ, Delson E et al (2005) Evolutionary morphing. In: Proceedings of the IEEE visualization, pp 431–438
Zurück zum Zitat Yamada H, Kondo S, Hanamura H, Townsend GC (2010) Tooth size in individuals with congenitally missing teeth: a study of Japanese males. Anthropol Sci 118:87–93 Yamada H, Kondo S, Hanamura H, Townsend GC (2010) Tooth size in individuals with congenitally missing teeth: a study of Japanese males. Anthropol Sci 118:87–93
Zurück zum Zitat Yaqoob O, DiBiase AT, Garvey T, Fleming PS (2011) Relationship between bilateral congenital absence of maxillary lateral incisors and anterior tooth width. Am J Orthod Dentofac Orthoped 139:e229–e233 Yaqoob O, DiBiase AT, Garvey T, Fleming PS (2011) Relationship between bilateral congenital absence of maxillary lateral incisors and anterior tooth width. Am J Orthod Dentofac Orthoped 139:e229–e233
Zurück zum Zitat Yuen KK, So LL, Tang EL (1997) Mesiodistal crown diameters of the primary and permanent teeth in southern Chinese—a longitudinal study. Eur J Orthod 19:721–731PubMed Yuen KK, So LL, Tang EL (1997) Mesiodistal crown diameters of the primary and permanent teeth in southern Chinese—a longitudinal study. Eur J Orthod 19:721–731PubMed
Zurück zum Zitat Zelditch M, Swiderski D, Sheets DH, Fink W (2004) Geometric morphometrics for biologists. Elsevier Academic Press, Cambridge Zelditch M, Swiderski D, Sheets DH, Fink W (2004) Geometric morphometrics for biologists. Elsevier Academic Press, Cambridge
Zurück zum Zitat 3Shape (2009) R700 orthodontics scanner. 3Shape A/S, Copenhagen K, Denmark 3Shape (2009) R700 orthodontics scanner. 3Shape A/S, Copenhagen K, Denmark
Metadaten
Titel
Three-dimensional geometric morphometric analysis of tooth shape in hypodontia: II size variation
verfasst von
Ibrahim AlShahrani
Publikationsdatum
10.08.2019
Verlag
Springer Singapore
Erschienen in
Anatomical Science International / Ausgabe 1/2020
Print ISSN: 1447-6959
Elektronische ISSN: 1447-073X
DOI
https://doi.org/10.1007/s12565-019-00497-z

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