Background
Results and discussion
Identification of new TQ targets by peptide array analysis
Network | Identified substrate | Phospho site | Prot ID | Folds up (24 h) |
---|---|---|---|---|
Cytoskeleton
| EphB1 | Y594 | NP_004432 | 2.93 |
Lamin A/C | S22 | CAA27173 | 2.45 | |
MAP2v | S1679 | NP_114034 | 2.30 | |
Syntaxin 1A | S14 | NP_004594 | 2.22 | |
Lamin B1 | S395 | NP_005564 | 2.12 | |
SNAP23 | T24 | NP_003816 | 2.08 | |
PI3K/AKT
| Lck | S158 | AAH13200 | 3.45 |
HSP22 | S14 | NP_0055180 | 3.32 | |
PKR | T451 | NP_002750 | 3.92 | |
Beta-2-adrenergic receptor-B2AR | S262 | NP_000015 | 2.80 | |
AKT1 | Y326 | NP_005154 | 2.22 | |
Bone marrow kinase BMX-ETK | Y40 | AAC08966 | 2.16 | |
Glucocorticoid receptor | S211 | NP_000167 | 2.15 | |
PAK1 | T212 | AAC24716 | 2.12 | |
Nitric oxide synthase 1 | S852 | NP_000611 | 2.09 | |
CHOP | S79 | NP_004074 | 2.08 | |
Metabotropic glutamate receptor 1 | T695 | AAA87843 | 2.05 | |
RAF1-c-RAF | S43 | NP_002871 | 2.00 | |
Wnt
| Beta-catenin | Y142 | NP_001895 | 2.89 |
T-cell transcription factor 4 | S60 | NP_110383 | 2.59 | |
N-myc | S263 | NP_005369 | 2.43 | |
L1 cell adhesion molecule | S1152 | NP_000416 | 2.25 | |
APC | S2054 | NP_000029 | 2.06 | |
MAP3K7-TAK1 | S192 | NP_663304 | 2.01 |
Database | Pathway | p-Value | Genes identified by peptide array |
---|---|---|---|
KEGG_PATHWAY | T cell receptor signaling pathway | 0.001971 | PDK1, AKT1, RAF1, PAK1*, MAP3K7 |
PANTHER_PATHWAY | Angiogenesis | 0.008722 | AKT1, TCF7L2, APC, RAF1, PAK1, CTNNB1, NOS1 |
KEGG_PATHWAY | MAPK signaling pathway | 0.041478 | MAX, AKT1, RAF1, PAK1, MAP3K7 |
KEGG_PATHWAY | Chemokine signaling pathway | 0.042726 | AKT1, CCR2, RAF1, PAK1 |
KEGG_PATHWAY | Renal cell carcinoma | 0.053539 | AKT1, RAF1, PAK1 |
PANTHER_PATHWAY | Ras Pathway | 0.054889 | AKT1, RAF1, PAK1, MAP3K7 |
BIOCARTA | Influence of Ras and Rho proteins on G1 to S Transition | 0.055681 | AKT1, RAF1, PAK1 |
KEGG_PATHWAY | ErbB signaling pathway | 0.079412 | AKT1, RAF1, PAK1 |
KEGG_PATHWAY | Focal adhesion | 0.091138 | AKT1, RAF1, PAK1, CTNNB1 |
KEGG_PATHWAY | Fc gamma R-mediated phagocytosis | 0.093575 | AKT1, RAF1, PAK1 |
BIOCARTA | MAPKinase Signaling Pathway | 0.094598 | MAX, RAF1, PAK1, MAP3K7 |
PANTHER_PATHWAY | Inflammation mediated by chemokine and cytokine signaling pathway | 0.229979 | AKT1, CCR2, RAF1, PAK1, MAP3K7 |
PANTHER_PATHWAY | T cell activation | 0.27141 | AKT1, RAF1, PAK1 |