Pancreatic ductal adenocarcinoma (PDAC) has one of the highest mortality rates of all cancers [ 1 – 3 ] and is predicted to be the second leading cause of cancer death in 2030 [ 4 ]. The 5-year survival rate for patients with PDAC is only 13% for …

Pediatric rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults [ 1 ], and each year it accounts for 3% of childhood cancers [ 2 ]. Based on histology, RMS can be classified in four main subtypes: embryonal RMS …

According to GLOBOCAN data, there were 495,773 new cases of pancreatic cancer in 2020, accounting for 2.6% of all cancer cases. Although pancreatic cancer is the 14th most prevalent cancer, it ranks 7th in terms of cancer-related deaths [ 1 ]. The …

Several studies have associated the presence of ADIPOQ gene polymorphisms with insulin resistance, adiponectin levels, and metabolic diseases such as diabetes, although with varying degrees of correlation depending on ethnicity. Here we aim to …

Metabolic Syndrome (MetS) is an increasing public health problem worldwide. It is a cluster of disorders that together lead to progressive disease with five times more vulnerable to developing diabetes mellitus type 2 (DM2) and 2.5 times more …

B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer progression. This immune checkpoint molecule is selectively expressed in both tumor cells and immune cells within the tumor microenvironment. In addition to its immune …

Cancer is currently the leading cause of human death globally, and increased rates of morbidity and mortality have been identified in recent years. The latest data released by the International Agency for Research on Cancer in 2020 showed that …

Recently, a pathological condition called cochlear synaptopathy has been clarified, and as a disorder of the auditory nerve synapses that occurs prior to failure of hair cells, it has been recognized as a major cause of sensorineural hearing loss.

Metastatic cancers prefer sanctuary sites such as the central nervous system (CNS), and the prognosis remains dire despite aggressive therapies [ 1 , 2 ]. Compartmental radioimmunotherapy (cRIT) administering radiolabeled tumor-specific monoclonal …

Alternative polyadenylation (APA) is emerging as a crucial regulatory mechanism in bladder cancer (BC), while it remains elusive whether APA influences the tumor immune microenvironment (TIME) in BC. We identified two distinct subtypes of BC by …

Adiponectin levels, the anti-inflammatory adipocytokine is reduced in hypertension and related to arterial stiffness1. The adiponectin -276G>T polymorphism is associated with type 2 diabetes and insulin resistance. However, whether this …

Glioblastoma (GBM) is the most common malignant primary brain tumor. The past decades have witnessed considerable advances in neurosurgery and radio-chemotherapy but limited survival benefits [ 1 ]. Many efforts were made to set several …