nach oben

Current Cardiovascular Imaging Reports

Erschienen in:

01.12.2014 | Intravascular Imaging (E Regar and U Landmesser, Section Editors)

Toward Clinical μOCT—A Review of Resolution-Enhancing Technical Advances

verfasst von: Kengyeh K. Chu, Giovanni J. Ughi, Linbo Liu, Guillermo J. Tearney

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 12/2014

Einloggen, um Zugang zu erhalten

Abstract

Intravascular optical coherence tomography (IVOCT) has made significant clinical impact, providing a method of visualizing coronary plaques, optimizing percutaneous coronary intervention, and monitoring treatment results. Achieving cellular resolution in cardiovascular optical coherence tomography (OCT) adds even greater utility; thin-cap fibroatheromas (TCFA) that include microcalcifications, cholesterol crystals, and macrophages are hypothesized to correlate with rupture potential, yet are too small to be imaged by conventional OCT. In this review, we survey new developments in the optical technology that may contribute to the advancement of IVOCT into the microscopic domain, including new light sources and optical configurations. We also describe recent progress in micro-OCT (μOCT), a high-resolution OCT implementation developed in our laboratory that utilizes many of these advances to achieve 1-μm resolution.

Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, et al. Optical coherence tomography. Science. 1991;254:1178–81.PubMedCrossRef

Jang IK, Bouma BE, Kang DH, Park SJ, Park SW, Seung KB, et al. Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. J Am Coll Cardiol. 2002;39:604–9.PubMedCrossRef

Yabushita H, Bouma BE, Houser SL, Aretz HT, Jang IK, Schlendorf KH, et al. Characterization of human atherosclerosis by optical coherence tomography. Circulation. 2002;106:1640–5.PubMedCrossRef

Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H, et al. In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013;6:1748–58. doi:10.1016/j.jacc.2013.05.071.CrossRef

Matsumoto D, Shite J, Shinke T, Otake H, Tanino Y, Ogasawara D, et al. Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography. Eur Heart J. 2007;28:961–7.PubMedCrossRef

Takano M, Inami S, Jang I-K, Yamamoto M, Murakami D, Seimiya K, et al. Evaluation by optical coherence tomography of neointimal coverage of sirolimus-eluting stent three months after implantation. Am J Cardiol. 2007;99:1033–8.PubMedCrossRef

Finn AV, Joner M, Nakazawa G, Kolodgie F, Newell J, John MC, et al. Pathological correlates of late drug-eluting stent thrombosis strut coverage as a marker of endothelialization. Circulation. 2007;115:2435–41.PubMedCrossRef

Chia S, Raffel OC, Takano M, Tearney GJ, Bouma BE, Jang IK. Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study. Coron Artery Dis. 2008;19:237–42. doi:10.1097/MCA.0b013e32830042a800019501-200806000-00004.PubMedCentralPubMedCrossRef

Takarada S, Imanishi T, Kubo T, Tanimoto T, Kitabata H, Nakamura N, et al. Effect of statin therapy on coronary fibrous-cap thickness in patients with acute coronary syndrome: assessment by optical coherence tomography study. Atherosclerosis. 2009;202:491–7.PubMedCrossRef

10.•

Guagliumi G, Costa MA, Sirbu V, Musumeci G, Bezerra HG, Suzuki N, et al. Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial. Circulation. 2011;123:274–81. doi:10.1161/CIRCULATIONAHA.110.963181. This work establishes an important connection between drug-eluting stents and uncovered or malapposed stent struts using an IVOCT trial.PubMedCrossRef

11.•

Farooq V, Gogas BD, Okamura T, Heo JH, Magro M, Gomez-Lara J, et al. Three-dimensional optical frequency domain imaging in conventional percutaneous coronary intervention: the potential for clinical application. Eur Heart J. 2013;34:875–85. doi:10.1093/eurheartj/ehr409. This is the first publication to directly evaluate the clinical application and relevance of 3D IVOCT.PubMedCrossRef

12.

Guagliumi G, Sirbu V, Musumeci G, Gerber R, Biondi-Zoccai G, Ikejima H, et al. Examination of the in vivo mechanisms of late drug-eluting stent thrombosis: findings from optical coherence tomography and intravascular ultrasound imaging. JACC: Cardiovasc Intervent. 2012;5:12–20.CrossRef

13.

Virmani R, Burke AP, Kolodgie FD, Farb A. Vulnerable plaque: the pathology of unstable coronary lesions. J Intervention Cardiol. 2002;15:439–46.CrossRef

14.

Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–75.PubMedCrossRef

15.

Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, Weinbaum S. Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries. Proc Natl Acad Sci U S A. 2013;110:10741–6. doi:10.1073/pnas.1308814110.PubMedCentralPubMedCrossRef

16.

Tian J, Ren X, Vergallo R, Xing L, Yu H, Jia H, et al. Distinct morphological features of ruptured culprit plaque for acute coronary events compared to those with silent rupture and thin-cap fibroatheroma: a combined optical coherence tomography and intravascular ultrasound study. J Am Coll Cardiol. 2014;63:2209–16. doi:10.1016/j.jacc.2014.01.061.PubMedCrossRef

17.

Kolodgie FD, Virmani R, Burke AP, Farb A, Weber DK, Kutys R, et al. Pathologic assessment of the vulnerable human coronary plaque. Heart. 2004;90:1385–91. doi:10.1136/hrt.2004.041798.PubMedCentralPubMedCrossRef

18.

Yun S, Tearney G, de Boer J, Iftimia N, Bouma B. High-speed optical frequency-domain imaging. Opt Express. 2003;11:2953–63.PubMedCentralPubMedCrossRef

19.

Tearney GJ, Waxman S, Shishkov M, Vakoc BJ, Suter MJ, Freilich MI, et al. Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging. JACC Cardiovasc Imaging. 2008;1:752–61. doi:10.1016/j.jcmg.2008.06.007.PubMedCentralPubMedCrossRef

20.

Häusler G, Lindner MW. “Coherence radar” and “spectral radar”—new tools for dermatological diagnosis. J Biomed Opt. 1998;3:21–31.CrossRef

21.

Lim H, De Boer J, Park B, Lee E, Yelin R, Yun S. Optical frequency domain imaging with a rapidly swept laser in the 815–870 nm range. Opt Express. 2006;14:5937–44.PubMedCrossRef

22.

Srinivasan VJ, Huber R, Gorczynska I, Fujimoto JG, Jiang JY, Reisen P, et al. High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm. Opt Lett. 2007;32:361–3.PubMedCrossRef

23.

Lee EC, de Boer JF, Mujat M, Lim H, Yun SH. In vivo optical frequency domain imaging of human retina and choroid. Opt Express. 2006;14:4403–11.PubMedCrossRef

24.

Potsaid B, Baumann B, Huang D, Barry S, Cable AE, Schuman JS, et al. Ultrahigh speed 1050 nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second. Opt Express. 2010;18:20029–48. doi:10.1364/OE.18.020029.PubMedCentralPubMedCrossRef

25.

Lee SW, Song HW, Jung MY, Kim SH. Wide tuning range wavelength-swept laser with a single SOA at 1020 nm for ultrahigh resolution Fourier-domain optical coherence tomography. Opt Express. 2011;19:21227–37. doi:10.1364/OE.19.021227.PubMedCrossRef

26.

Walewski J, Sanders S. High-resolution wavelength-agile laser source based on pulsed super-continua. Appl Phys B. 2004;79:415–8.CrossRef

27.

Yun SH, Bouma BE. Wavelength swept lasers. In: Drexler W, Fujimoto JG, editors. Optical coherence tomography: technology and applications. Berlin: Springer-Verlag; 2008. p. 359–77.CrossRef

28.

Bouma B, Tearney GJ, Boppart SA, Hee MR, Brezinski ME, Fujimoto JG. High-resolution optical coherence tomographic imaging using a mode-locked Ti:Al(2)O(3) laser source. Opt Lett. 1995;20:1486–8.PubMedCrossRef

29.

Wojtkowski M, Srinivasan V, Ko T, Fujimoto J, Kowalczyk A, Duker J. Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation. Opt Express. 2004;12:2404–22.PubMedCrossRef

30.

Morgner U, Kärtner F, Cho S-H, Chen Y, Haus HA, Fujimoto JG, et al. Sub-two-cycle pulses from a Kerr-lens mode-locked Ti: sapphire laser. Opt Lett. 1999;24:411–3.PubMedCrossRef

31.

Wang Y, Zhao Y, Nelson J, Chen Z, Windeler RS. Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber. Opt Lett. 2003;28:182–4.PubMedCrossRef

32.

Marks DL, Oldenburg AL, Reynolds JJ, Boppart SA. Study of an ultrahigh-numerical-aperture fiber continuum generation source for optical coherence tomography. Opt Lett. 2002;27:2010–2.PubMedCrossRef

33.

Povazay B, Bizheva K, Unterhuber A, Hermann B, Sattmann H, Fercher AF, et al. Submicrometer axial resolution optical coherence tomography. Opt Lett. 2002;27:1800–2.PubMedCrossRef

34.

Kray S, Grychtol P, Hermes B, Bornemann J, Kurz H. Simultaneous dual-band ultra-high resolution optical coherence tomography. Opt Express. 2007;15:10832–41.PubMedCrossRef

35.

WhiteLase SC480: Ultra High-Power Supercontinuum Fiber Laser. Available at: http://www.fianium.com/pdf/WhiteLase_SC480_BrightLase_v1.pdf. Accessed Aug 8, 2014.

36.

Cimalla P, Walther J, Mehner M, Cuevas M, Koch E. Simultaneous dual-band optical coherence tomography in the spectral domain for high resolution in vivo imaging. Opt Express. 2009;17:19486–500.PubMedCrossRef

37.

SuperK EXTREME: High Power Supercontinuum Fiber Laser Series. Available at: http://www.nktphotonics.com/files/files/SuperK_EXTREME.pdf. Accessed Aug 8, 2014.

38.

Jeon MY, Zhang J, Wang Q, Chen Z. High-speed and wide bandwidth Fourier domain mode-locked wavelength swept laser with multiple SOAs. Opt Express. 2008;16:2547–54.PubMedCentralPubMedCrossRef

39.

Jang W, Lim J, Kim H, Ha J. Broadband wavelength swept source combining a quantum dot and a quantum well SOA in the wavelength range of 1153–1366 nm. Electron Lett. 2013;49:1205–6.CrossRef

40.

Ding Z, Ren H, Zhao Y, Nelson JS, Chen Z. High-resolution optical coherence tomography over a large depth range with an axicon lens. Opt Lett. 2002;27:243–5.PubMedCrossRef

41.

Leitgeb R, Villiger M, Bachmann A, Steinmann L, Lasser T. Extended focus depth for Fourier domain optical coherence microscopy. Opt Lett. 2006;31:2450–2.PubMedCrossRef

42.

Lee K-S, Rolland JP. Bessel beam spectral-domain high-resolution optical coherence tomography with micro-optic axicon providing extended focusing range. Opt Lett. 2008;33:1696–8.PubMedCrossRef

43.

Lorenser D, Yang X, Sampson DD. Ultrathin fiber probes with extended depth of focus for optical coherence tomography. Opt Lett. 2012;37:1616–8.PubMedCrossRef

44.

Liu L, Liu C, Howe WC, Sheppard CJ, Chen N. Binary-phase spatial filter for real-time swept-source optical coherence microscopy. Opt Lett. 2007;32:2375–7.PubMedCrossRef

45.

Ralston TS, Marks DL, Carney PS, Boppart SA. Interferometric synthetic aperture microscopy. Nat Phys. 2007;3:129–34.CrossRef

46.

Ralston TS, Marks DL, Carney PS, Boppart SA. Real-time interferometric synthetic aperture microscopy. Opt Express. 2008;16:2555–69.PubMedCentralPubMedCrossRef

47.

Ahmad A, Shemonski ND, Adie SG, Kim HS, Hwu WM, Carney PS, et al. Real-time in vivo computed optical interferometric tomography. Nat Photon. 2013;7:444–8. doi:10.1038/nphoton.2013.71.CrossRef

48.

Mo J, de Groot M, de Boer JF. Focus-extension by depth-encoded synthetic aperture in Optical Coherence Tomography. Opt Express. 2013;21:10048–61. doi:10.1364/OE.21.010048.PubMedCrossRef

49.••

Liu L, Gardecki JA, Nadkarni SK, Toussaint JD, Yagi Y, Bouma BE, et al. Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography. Nat Med. 2011;17:1010–4. doi:10.1038/nm.2409nm.2409. This work represents the highest resolution OCT imaging of coronary arteries known to date.PubMedCentralPubMedCrossRef

50.

Kashiwagi M, Liu L, Chu KK, Sun CH, Tanaka A, Gardecki JA, et al. Feasibility of the assessment of cholesterol crystals in human macrophages using micro optical coherence tomography. PLoS One. 2014;9:e102669. doi:10.1371/journal.pone.0102669.PubMedCentralPubMedCrossRef

51.

Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464:1357–61. doi:10.1038/nature08938.PubMedCentralPubMedCrossRef

52.

Vakhtin AB, Kane DJ, Wood WR, Peterson KA. Common-path interferometer for frequency-domain optical coherence tomography. Appl Opt. 2003;42:6953–8.PubMedCrossRef

53.

Chu KK, Carruth RW, Singh K, Ma H, Winkelmann J, Rowe SM, et al. Linear scanning micro-optical coherence tomography probe for imaging of mucociliary transport in airways. San Francisco: SPIE Photonics West; 2014.

Titel: Toward Clinical μOCT—A Review of Resolution-Enhancing Technical Advances
verfasst von: Kengyeh K. Chu
Giovanni J. Ughi
Linbo Liu
Guillermo J. Tearney
Publikationsdatum: 01.12.2014
Verlag: Springer US
Erschienen in: Current Cardiovascular Imaging Reports / Ausgabe 12/2014
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-014-9308-7

Neu im Fachgebiet Kardiologie

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Adipositas-Medikament auch gegen Schlafapnoe wirksam

24.04.2024 Adipositas Nachrichten

Der als Antidiabetikum sowie zum Gewichtsmanagement zugelassene Wirkstoff Tirzepatid hat in Studien bei adipösen Patienten auch schlafbezogene Atmungsstörungen deutlich reduziert, informiert der Hersteller in einer Vorab-Meldung zum Studienausgang.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2014

Development of Tissue Characterization Using Optical Coherence Tomography for Defining Coronary Plaque Morphology and the Vascular Responses After Coronary Stent Implantation

Echocardiographic Assessment of Cardiac Dyssynchrony. Where do We Stand?

Current Development of Molecular Coronary Plaque Imaging using Magnetic Resonance Imaging towards Clinical Application

Three-dimensional Echocardiographic Analysis of left Atrial size and Volumetric Function — Clinical Implications and Comparison with Other Imaging Modalities