Erschienen in:
01.06.2005 | Poster Presentation
TP53 mutations among molecular subtypes of HER2-positive tumors
verfasst von:
Å Helland, M Nicolau, Y Ji, A Langerød, DE Sommervoll, A Bergamaschi, JR Pollack, A-L Børresen-Dale, SS Jeffrey
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2005
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Excerpt
The HER2/ERBB2 receptor tyrosine kinase plays a critical role in the pathogenesis of breast cancer. Amplification and/or overexpression of HER2 occurs in 20–30% of Caucasian breast cancers and correlates with poor prognosis. However, within the group of patients overexpressing HER2, there are obvious differences regarding the course of the disease. This study identifies different molecular subtypes among 47 HER2-positive tumors based on genome-wide expression profiling. A subset of these tumors was analyzed for TP53 mutations, a gene commonly mutated among breast carcinomas. …