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01.07.2008 | Biological Child and Adolescent Psychiatry - Original Article

Transmission disequilibrium studies in early onset of obsessive–compulsive disorder for polymorphisms in genes of the dopaminergic system

verfasst von: Susanne Walitza, André Scherag, Tobias J. Renner, Anke Hinney, Helmut Remschmidt, Beate Herpertz-Dahlmann, Eberhard Schulz, Helmut Schafer, Klaus W. Lange, Christoph Wewetzer, Manfred Gerlach

Erschienen in: Journal of Neural Transmission | Ausgabe 7/2008

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Abstract

The dopaminergic system has been shown to be involved in the aetiology of obsessive–compulsive disorder (OCD). Family studies suggest a higher genetic loading in patients with early onset OCD. Our investigation is the first family-based association study concerning polymorphisms in genes of the dopaminergic system in early onset OCD. We studied polymorphisms within the dopamine-4 receptor gene (DRD4), the dopamine transporter gene (DAT1) and the catecholamine-O-methyltransferase gene (COMT). Associations of alleles of DRD4 and COMT with OCD have previously been reported in adults, while a trend towards an association was found for DAT1 alleles. In our study we observed transmission disequilibrium for the 48-bp repeat polymorphism of the DRD4 gene using the ETDT (P = 0.047) in 69 trios comprising patients with early onset OCD and both of their parents. Post hoc TDT analysis of the DRD4 showed reduced transmission of the 4-repeat allele and a slightly increased transmission rate for the 7- and the 2-repeat allele. No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group.

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Titel: Transmission disequilibrium studies in early onset of obsessive–compulsive disorder for polymorphisms in genes of the dopaminergic system
verfasst von: Susanne Walitza
André Scherag
Tobias J. Renner
Anke Hinney
Helmut Remschmidt
Beate Herpertz-Dahlmann
Eberhard Schulz
Helmut Schafer
Klaus W. Lange
Christoph Wewetzer
Manfred Gerlach
Publikationsdatum: 01.07.2008
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 7/2008
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0051-6

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Transmission disequilibrium studies in early onset of obsessive–compulsive disorder for polymorphisms in genes of the dopaminergic system

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