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Erschienen in: Current Treatment Options in Oncology 12/2021

01.12.2021 | Palliative and Supportive Care (MP Davis, Section Editor)

Treating Chronic Pain with Buprenorphine—The Practical Guide

verfasst von: Amy A. Case, Justin Kullgren, Sidra Anwar, Sandra Pedraza, Mellar P. Davis

Erschienen in: Current Treatment Options in Oncology | Ausgabe 12/2021

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Opinion statement

Buprenorphine has unique and favorable pharmacological properties that make it useful in a variety of clinical scenarios. It has been recommended to consider buprenorphine first-line opioid for chronic pain, especially in the elderly as it may be associated with less cognitive impairment, falls, sexual dysfunction, and sarcopenia when compared with schedule II opioids. It may be useful in patients with comorbid substance use disorder or non-medical opioid use, as there is less risk of misuse, euphoria and it may improve mood. When used to treat opioid use disorder, the training and waiver was recently waived for licensed practitioners with a DEA and any provider may prescribe buprenorphine. For many reasons outlined in this article, the popularity of using buprenorphine for analgesia continues to grow and a practitioner should consider this as an excellent and safe option for chronic pain.
Literatur
1.
Zurück zum Zitat Dahlhamer J, et al. Prevalence of chronic pain and high-impact chronic pain among adults - United States, 2016. MMWR Morb Mortal Wkly Rep. 2018;67(36):1001–6.PubMedPubMedCentralCrossRef Dahlhamer J, et al. Prevalence of chronic pain and high-impact chronic pain among adults - United States, 2016. MMWR Morb Mortal Wkly Rep. 2018;67(36):1001–6.PubMedPubMedCentralCrossRef
2.•
Zurück zum Zitat Davis MP, Pasternak G, Behm B. Treating chronic pain: an overview of clinical studies centered on the buprenorphine option. Drugs. 2018;78(12):1211–28. Comprehensive review of the use of buprenorphine for pain.PubMedPubMedCentralCrossRef Davis MP, Pasternak G, Behm B. Treating chronic pain: an overview of clinical studies centered on the buprenorphine option. Drugs. 2018;78(12):1211–28. Comprehensive review of the use of buprenorphine for pain.PubMedPubMedCentralCrossRef
3.••
Zurück zum Zitat Webster L, et al. Understanding buprenorphine for use in chronic pain: expert opinion. Pain Med. 2020;21(4):714–23. Consensus panel recommendations regarding the use and opioid rotation to buprenorphine for pain.PubMedPubMedCentralCrossRef Webster L, et al. Understanding buprenorphine for use in chronic pain: expert opinion. Pain Med. 2020;21(4):714–23. Consensus panel recommendations regarding the use and opioid rotation to buprenorphine for pain.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Pergolizzi JV Jr. And R.B. Raffa, safety and efficacy of the unique opioid buprenorphine for the treatment of chronic pain. J Pain Res. 2019;12:3299–317.PubMedCrossRef Pergolizzi JV Jr. And R.B. Raffa, safety and efficacy of the unique opioid buprenorphine for the treatment of chronic pain. J Pain Res. 2019;12:3299–317.PubMedCrossRef
7.
Zurück zum Zitat Suboxone Sublingual Film Prescribing Information. 2019. Indivior Inc.: North Chesterfield. Suboxone Sublingual Film Prescribing Information. 2019. Indivior Inc.: North Chesterfield.
8.
Zurück zum Zitat Buprenex Prescribing Information. 2019. Indivior Inc.: North Chesterfield. Buprenex Prescribing Information. 2019. Indivior Inc.: North Chesterfield.
9.
Zurück zum Zitat Subutex Prescribing Information. 2015. Roxane Laboratories, Inc.: Columbus. Subutex Prescribing Information. 2015. Roxane Laboratories, Inc.: Columbus.
10.
Zurück zum Zitat Zubsolv Prescribing Information. 2019. Orexo US Inc.: Morristown, NJ. Zubsolv Prescribing Information. 2019. Orexo US Inc.: Morristown, NJ.
11.
Zurück zum Zitat Butrans Prescribing Information. 2019. Perdue Pharm L.P.: Stamford. Butrans Prescribing Information. 2019. Perdue Pharm L.P.: Stamford.
12.
Zurück zum Zitat Greenwald M, et al. Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices. Biol Psychiatry. 2007;61(1):101–10.PubMedCrossRef Greenwald M, et al. Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices. Biol Psychiatry. 2007;61(1):101–10.PubMedCrossRef
13.
Zurück zum Zitat Elkader A, Sproule B. Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence. Clin Pharmacokinet. 2005;44(7):661–80.PubMedCrossRef Elkader A, Sproule B. Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence. Clin Pharmacokinet. 2005;44(7):661–80.PubMedCrossRef
14.
Zurück zum Zitat Chang Y, Moody DE. Glucuronidation of buprenorphine and norbuprenorphine by human liver microsomes and UDP-glucuronosyltransferases. Drug Metab Lett. 2009;3(2):101–7.PubMedCrossRef Chang Y, Moody DE. Glucuronidation of buprenorphine and norbuprenorphine by human liver microsomes and UDP-glucuronosyltransferases. Drug Metab Lett. 2009;3(2):101–7.PubMedCrossRef
15.
Zurück zum Zitat Cone EJ, et al. The metabolism and excretion of buprenorphine in humans. Drug Metab Dispos. 1984;12(5):577–81.PubMed Cone EJ, et al. The metabolism and excretion of buprenorphine in humans. Drug Metab Dispos. 1984;12(5):577–81.PubMed
16.
Zurück zum Zitat Verbeeck RK. Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol. 2008;64(12):1147–61.PubMedCrossRef Verbeeck RK. Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol. 2008;64(12):1147–61.PubMedCrossRef
17.
Zurück zum Zitat Alhaddad H, et al. Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice. Crit Care Med. 2012;40(12):3215–23.PubMedCrossRef Alhaddad H, et al. Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice. Crit Care Med. 2012;40(12):3215–23.PubMedCrossRef
18.
Zurück zum Zitat Huang P, et al. Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist. J Pharmacol Exp Ther. 2001;297(2):688–95.PubMed Huang P, et al. Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist. J Pharmacol Exp Ther. 2001;297(2):688–95.PubMed
19.
Zurück zum Zitat Ohtani M, et al. Comparative analysis of buprenorphine- and norbuprenorphine-induced analgesic effects based on pharmacokinetic-pharmacodynamic modeling. J Pharmacol Exp Ther. 1995;272(2):505–10.PubMed Ohtani M, et al. Comparative analysis of buprenorphine- and norbuprenorphine-induced analgesic effects based on pharmacokinetic-pharmacodynamic modeling. J Pharmacol Exp Ther. 1995;272(2):505–10.PubMed
20.
Zurück zum Zitat Tournier N, et al. Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010;13(7):905–15.PubMedCrossRef Tournier N, et al. Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010;13(7):905–15.PubMedCrossRef
21.
Zurück zum Zitat Boger RH. Renal impairment: a challenge for opioid treatment? The role of buprenorphine. Palliat Med. 2006;20(Suppl 1):s17–23.PubMedCrossRef Boger RH. Renal impairment: a challenge for opioid treatment? The role of buprenorphine. Palliat Med. 2006;20(Suppl 1):s17–23.PubMedCrossRef
22.
Zurück zum Zitat Middleton LS, et al. The pharmacodynamic and pharmacokinetic profile of intranasal crushed buprenorphine and buprenorphine/naloxone tablets in opioid abusers. Addiction. 2011;106(8):1460–73.PubMedPubMedCentralCrossRef Middleton LS, et al. The pharmacodynamic and pharmacokinetic profile of intranasal crushed buprenorphine and buprenorphine/naloxone tablets in opioid abusers. Addiction. 2011;106(8):1460–73.PubMedPubMedCentralCrossRef
23.
Zurück zum Zitat Volpe DA, et al. Uniform assessment and ranking of opioid mu receptor binding constants for selected opioid drugs. Regul Toxicol Pharmacol. 2011;59(3):385–90.PubMedCrossRef Volpe DA, et al. Uniform assessment and ranking of opioid mu receptor binding constants for selected opioid drugs. Regul Toxicol Pharmacol. 2011;59(3):385–90.PubMedCrossRef
24.
Zurück zum Zitat Gudin J, Fudin J. A narrative pharmacological review of buprenorphine: a unique opioid for the treatment of chronic pain. Pain Ther. 2020;9(1):41–54.PubMedPubMedCentralCrossRef Gudin J, Fudin J. A narrative pharmacological review of buprenorphine: a unique opioid for the treatment of chronic pain. Pain Ther. 2020;9(1):41–54.PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Dahan A, et al. Buprenorphine induces ceiling in respiratory depression but not in analgesia. Br J Anaesth. 2006;96(5):627–32.PubMedCrossRef Dahan A, et al. Buprenorphine induces ceiling in respiratory depression but not in analgesia. Br J Anaesth. 2006;96(5):627–32.PubMedCrossRef
26.
Zurück zum Zitat Raehal KM, Bohn LM. The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics. Neuropharmacology. 2011;60(1):58–65.PubMedCrossRef Raehal KM, Bohn LM. The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics. Neuropharmacology. 2011;60(1):58–65.PubMedCrossRef
27.
Zurück zum Zitat Raehal KM, Walker JK, Bohn LM. Morphine side effects in beta-arrestin 2 knockout mice. J Pharmacol Exp Ther. 2005;314(3):1195–201.PubMedCrossRef Raehal KM, Walker JK, Bohn LM. Morphine side effects in beta-arrestin 2 knockout mice. J Pharmacol Exp Ther. 2005;314(3):1195–201.PubMedCrossRef
29.
Zurück zum Zitat MacLean KA, et al. Dose-related effects of salvinorin a in humans: dissociative, hallucinogenic, and memory effects. Psychopharmacology. 2013;226(2):381–92.PubMedCrossRef MacLean KA, et al. Dose-related effects of salvinorin a in humans: dissociative, hallucinogenic, and memory effects. Psychopharmacology. 2013;226(2):381–92.PubMedCrossRef
30.
Zurück zum Zitat Pfeiffer A, et al. Psychotomimesis mediated by kappa opiate receptors. Science. 1986;233(4765):774–6.PubMedCrossRef Pfeiffer A, et al. Psychotomimesis mediated by kappa opiate receptors. Science. 1986;233(4765):774–6.PubMedCrossRef
31.•
Zurück zum Zitat Ahmadi J, Jahromi MS, Ehsaei Z. The effectiveness of different singly administered high doses of buprenorphine in reducing suicidal ideation in acutely depressed people with co-morbid opiate dependence: a randomized, double-blind, clinical trial. Trials. 2018;19(1):462. A randomized, double-blind trial that suggests a single high dose of buprenorphine could rapidly treat suicidal ideation.PubMedPubMedCentralCrossRef Ahmadi J, Jahromi MS, Ehsaei Z. The effectiveness of different singly administered high doses of buprenorphine in reducing suicidal ideation in acutely depressed people with co-morbid opiate dependence: a randomized, double-blind, clinical trial. Trials. 2018;19(1):462. A randomized, double-blind trial that suggests a single high dose of buprenorphine could rapidly treat suicidal ideation.PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Falcon E, et al. Antidepressant-like effects of buprenorphine are mediated by kappa opioid receptors. Neuropsychopharmacology. 2016;41(9):2344–51.PubMedPubMedCentralCrossRef Falcon E, et al. Antidepressant-like effects of buprenorphine are mediated by kappa opioid receptors. Neuropsychopharmacology. 2016;41(9):2344–51.PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Lutfy K, Cowan A. Buprenorphine: a unique drug with complex pharmacology. Curr Neuropharmacol. 2004;2(4):395–402.PubMedCrossRef Lutfy K, Cowan A. Buprenorphine: a unique drug with complex pharmacology. Curr Neuropharmacol. 2004;2(4):395–402.PubMedCrossRef
34.
Zurück zum Zitat Johnson RE, Strain EC, Amass L. Buprenorphine: how to use it right. Drug Alcohol Depend. 2003;70(2 Suppl):S59–77.PubMedCrossRef Johnson RE, Strain EC, Amass L. Buprenorphine: how to use it right. Drug Alcohol Depend. 2003;70(2 Suppl):S59–77.PubMedCrossRef
35.
Zurück zum Zitat Khanna IK, Pillarisetti S. Buprenorphine - an attractive opioid with underutilized potential in treatment of chronic pain. J Pain Res. 2015;8:859–70.PubMedPubMedCentral Khanna IK, Pillarisetti S. Buprenorphine - an attractive opioid with underutilized potential in treatment of chronic pain. J Pain Res. 2015;8:859–70.PubMedPubMedCentral
36.
Zurück zum Zitat Ding Z, Raffa RB. Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine. Br J Pharmacol. 2009;157(5):831–43.PubMedPubMedCentralCrossRef Ding Z, Raffa RB. Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine. Br J Pharmacol. 2009;157(5):831–43.PubMedPubMedCentralCrossRef
37.
Zurück zum Zitat Tejwani GA, Rattan AK, McDonald JS. Role of spinal opioid receptors in the antinociceptive interactions between intrathecal morphine and bupivacaine. Anesth Analg. 1992;74(5):726–34.PubMedCrossRef Tejwani GA, Rattan AK, McDonald JS. Role of spinal opioid receptors in the antinociceptive interactions between intrathecal morphine and bupivacaine. Anesth Analg. 1992;74(5):726–34.PubMedCrossRef
38.
Zurück zum Zitat Mercadante S, et al. Safety and effectiveness of intravenous morphine for episodic breakthrough pain in patients receiving transdermal buprenorphine. J Pain Symptom Manag. 2006;32(2):175–9.CrossRef Mercadante S, et al. Safety and effectiveness of intravenous morphine for episodic breakthrough pain in patients receiving transdermal buprenorphine. J Pain Symptom Manag. 2006;32(2):175–9.CrossRef
39.
Zurück zum Zitat Emery MA, Eitan S. Members of the same pharmacological family are not alike: different opioids, different consequences, hope for the opioid crisis? Prog Neuro-Psychopharmacol Biol Psychiatry. 2019;92:428–49.CrossRef Emery MA, Eitan S. Members of the same pharmacological family are not alike: different opioids, different consequences, hope for the opioid crisis? Prog Neuro-Psychopharmacol Biol Psychiatry. 2019;92:428–49.CrossRef
40.
Zurück zum Zitat Lintzeris N, et al. Transferring patients from methadone to buprenorphine: the feasibility and evaluation of practice guidelines. J Addict Med. 2018;12(3):234–40.PubMedPubMedCentralCrossRef Lintzeris N, et al. Transferring patients from methadone to buprenorphine: the feasibility and evaluation of practice guidelines. J Addict Med. 2018;12(3):234–40.PubMedPubMedCentralCrossRef
41.
Zurück zum Zitat Mannelli P, et al. Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives. Curr Drug Abuse Rev. 2012;5(1):52–63.PubMedPubMedCentralCrossRef Mannelli P, et al. Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives. Curr Drug Abuse Rev. 2012;5(1):52–63.PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Malinoff HL, Barkin RL, Wilson G. Sublingual buprenorphine is effective in the treatment of chronic pain syndrome. Am J Ther. 2005;12(5):379–84.PubMedCrossRef Malinoff HL, Barkin RL, Wilson G. Sublingual buprenorphine is effective in the treatment of chronic pain syndrome. Am J Ther. 2005;12(5):379–84.PubMedCrossRef
43.
Zurück zum Zitat Mercadante S, et al. Equipotent doses to switch from high doses of opioids to transdermal buprenorphine. Support Care Cancer. 2009;17(6):715–8.PubMedCrossRef Mercadante S, et al. Equipotent doses to switch from high doses of opioids to transdermal buprenorphine. Support Care Cancer. 2009;17(6):715–8.PubMedCrossRef
44.
Zurück zum Zitat Mercadante S, et al. Switching from transdermal drugs: an observational "N of 1" study of fentanyl and buprenorphine. J Pain Symptom Manag. 2007;34(5):532–8.CrossRef Mercadante S, et al. Switching from transdermal drugs: an observational "N of 1" study of fentanyl and buprenorphine. J Pain Symptom Manag. 2007;34(5):532–8.CrossRef
45.
Zurück zum Zitat Likar R, et al. Comparable analgesic efficacy of transdermal buprenorphine in patients over and under 65 years of age. Clin J Pain. 2008;24(6):536–43.PubMedCrossRef Likar R, et al. Comparable analgesic efficacy of transdermal buprenorphine in patients over and under 65 years of age. Clin J Pain. 2008;24(6):536–43.PubMedCrossRef
46.
Zurück zum Zitat Lundorff L, et al. Switching from high doses of pure mu-opioid agonists to transdermal buprenorphine in patients with cancer: a feasibility study. J Opioid Manag. 2013;9(4):255–62.PubMedCrossRef Lundorff L, et al. Switching from high doses of pure mu-opioid agonists to transdermal buprenorphine in patients with cancer: a feasibility study. J Opioid Manag. 2013;9(4):255–62.PubMedCrossRef
47.
Zurück zum Zitat Freye E, et al. Opioid rotation from high-dose morphine to transdermal buprenorphine (Transtec) in chronic pain patients. Pain Pract. 2007;7(2):123–9.PubMedCrossRef Freye E, et al. Opioid rotation from high-dose morphine to transdermal buprenorphine (Transtec) in chronic pain patients. Pain Pract. 2007;7(2):123–9.PubMedCrossRef
48.
Zurück zum Zitat Sittl R, Griessinger N, Likar R. Analgesic efficacy and tolerability of transdermal buprenorphine in patients with inadequately controlled chronic pain related to cancer and other disorders: a multicenter, randomized, double-blind, placebo-controlled trial. Clin Ther. 2003;25(1):150–68.PubMedCrossRef Sittl R, Griessinger N, Likar R. Analgesic efficacy and tolerability of transdermal buprenorphine in patients with inadequately controlled chronic pain related to cancer and other disorders: a multicenter, randomized, double-blind, placebo-controlled trial. Clin Ther. 2003;25(1):150–68.PubMedCrossRef
49.••
Zurück zum Zitat Sittl R, Likar R, Nautrup BP. Equipotent doses of transdermal fentanyl and transdermal buprenorphine in patients with cancer and noncancer pain: results of a retrospective cohort study. Clin Ther. 2005;27(2):225–37. Buprenorphine transdermal system was shown to be an effective analgesic against chronic, severe pain in this study population. Patients treated with this new formulation of buprenorphine showed improved duration of sleep and reduced need for additional oral analgesics.PubMedCrossRef Sittl R, Likar R, Nautrup BP. Equipotent doses of transdermal fentanyl and transdermal buprenorphine in patients with cancer and noncancer pain: results of a retrospective cohort study. Clin Ther. 2005;27(2):225–37. Buprenorphine transdermal system was shown to be an effective analgesic against chronic, severe pain in this study population. Patients treated with this new formulation of buprenorphine showed improved duration of sleep and reduced need for additional oral analgesics.PubMedCrossRef
50.
Zurück zum Zitat Kornfeld H, Reetz H. Transdermal buprenorphine, opioid rotation to sublingual buprenorphine, and the avoidance of precipitated withdrawal: a review of the literature and demonstration in three chronic pain patients treated with butrans. Am J Ther. 2015;22(3):199–205.PubMedCrossRef Kornfeld H, Reetz H. Transdermal buprenorphine, opioid rotation to sublingual buprenorphine, and the avoidance of precipitated withdrawal: a review of the literature and demonstration in three chronic pain patients treated with butrans. Am J Ther. 2015;22(3):199–205.PubMedCrossRef
51.
Zurück zum Zitat Kornfeld H. Buprenorphine as a safety net for opioid treatment of nonmalignant pain. Arch Intern Med. 2011;171(6):596–7.PubMedCrossRef Kornfeld H. Buprenorphine as a safety net for opioid treatment of nonmalignant pain. Arch Intern Med. 2011;171(6):596–7.PubMedCrossRef
52.
Zurück zum Zitat Saal D, Lee F. Rapid induction therapy for opioid-use disorder using buprenorphine transdermal patch: a case series. Perm J. 2020;24. Saal D, Lee F. Rapid induction therapy for opioid-use disorder using buprenorphine transdermal patch: a case series. Perm J. 2020;24.
53.
Zurück zum Zitat Silverman S, et al. Use of immediate-release opioids as supplemental analgesia during management of moderate-to-severe chronic pain with buprenorphine transdermal system. J Pain Res. 2017;10:1255–63.PubMedPubMedCentralCrossRef Silverman S, et al. Use of immediate-release opioids as supplemental analgesia during management of moderate-to-severe chronic pain with buprenorphine transdermal system. J Pain Res. 2017;10:1255–63.PubMedPubMedCentralCrossRef
54.
Zurück zum Zitat Edge WG, Cooper GM, Morgan M. Analgesic effects of sublingual buprenorphine. Anaesthesia. 1979;34(5):463–7.PubMedCrossRef Edge WG, Cooper GM, Morgan M. Analgesic effects of sublingual buprenorphine. Anaesthesia. 1979;34(5):463–7.PubMedCrossRef
55.
Zurück zum Zitat Cuschieri RJ, Morran CG, McArdle CS. Comparison of morphine and sublingual buprenorphine following abdominal surgery. Br J Anaesth. 1984;56(8):855–9.PubMedCrossRef Cuschieri RJ, Morran CG, McArdle CS. Comparison of morphine and sublingual buprenorphine following abdominal surgery. Br J Anaesth. 1984;56(8):855–9.PubMedCrossRef
56.
Zurück zum Zitat Ellis R, et al. Pain relief after abdominal surgery--a comparison of i.m. morphine, sublingual buprenorphine and self-administered i.v. pethidine. Br J Anaesth. 1982;54(4):421–8.PubMedCrossRef Ellis R, et al. Pain relief after abdominal surgery--a comparison of i.m. morphine, sublingual buprenorphine and self-administered i.v. pethidine. Br J Anaesth. 1982;54(4):421–8.PubMedCrossRef
57.
Zurück zum Zitat Daitch J, et al. Conversion of chronic pain patients from full-opioid agonists to sublingual buprenorphine. Pain Phys. 2012;15(3 Suppl):ES59–66.CrossRef Daitch J, et al. Conversion of chronic pain patients from full-opioid agonists to sublingual buprenorphine. Pain Phys. 2012;15(3 Suppl):ES59–66.CrossRef
58.
Zurück zum Zitat Priestley T, et al. Converting from transdermal to buccal formulations of buprenorphine: a pharmacokinetic meta-model simulation in healthy volunteers. Pain Med. 2018;19(10):1988–96.PubMedCrossRef Priestley T, et al. Converting from transdermal to buccal formulations of buprenorphine: a pharmacokinetic meta-model simulation in healthy volunteers. Pain Med. 2018;19(10):1988–96.PubMedCrossRef
59.
Zurück zum Zitat Webster L, et al. Evaluation of the tolerability of switching patients on chronic full mu-opioid agonist therapy to buccal buprenorphine. Pain Med. 2016;17(5):899–907.PubMedPubMedCentral Webster L, et al. Evaluation of the tolerability of switching patients on chronic full mu-opioid agonist therapy to buccal buprenorphine. Pain Med. 2016;17(5):899–907.PubMedPubMedCentral
60.•
Zurück zum Zitat Hammig R, et al. Use of microdoses for induction of buprenorphine treatment with overlapping full opioid agonist use: the Bernese method. Subst Abus Rehabil. 2016;7:99–105. The first paper to describe the microdosing method of opioid rotation to buprenorphine.CrossRef Hammig R, et al. Use of microdoses for induction of buprenorphine treatment with overlapping full opioid agonist use: the Bernese method. Subst Abus Rehabil. 2016;7:99–105. The first paper to describe the microdosing method of opioid rotation to buprenorphine.CrossRef
61.
Zurück zum Zitat Terasaki D, Smith C, Calcaterra SL. Transitioning hospitalized patients with opioid use disorder from methadone to buprenorphine without a period of opioid abstinence using a microdosing protocol. Pharmacotherapy. 2019;39(10):1023–9.PubMedCrossRef Terasaki D, Smith C, Calcaterra SL. Transitioning hospitalized patients with opioid use disorder from methadone to buprenorphine without a period of opioid abstinence using a microdosing protocol. Pharmacotherapy. 2019;39(10):1023–9.PubMedCrossRef
63.
Zurück zum Zitat Randhawa PA, Brar R, Nolan S. Buprenorphine-naloxone "microdosing": an alternative induction approach for the treatment of opioid use disorder in the wake of North America's increasingly potent illicit drug market. CMAJ. 2020;192(3):E73.PubMedPubMedCentralCrossRef Randhawa PA, Brar R, Nolan S. Buprenorphine-naloxone "microdosing": an alternative induction approach for the treatment of opioid use disorder in the wake of North America's increasingly potent illicit drug market. CMAJ. 2020;192(3):E73.PubMedPubMedCentralCrossRef
64.
Zurück zum Zitat De Aquino JP, et al. Rapid transition from methadone to buprenorphine utilizing a micro-dosing protocol in the outpatient veteran affairs setting. J Addict Med. 2020;14(5):e271–3.PubMedPubMedCentralCrossRef De Aquino JP, et al. Rapid transition from methadone to buprenorphine utilizing a micro-dosing protocol in the outpatient veteran affairs setting. J Addict Med. 2020;14(5):e271–3.PubMedPubMedCentralCrossRef
65.
Zurück zum Zitat Rozylo J, et al. Case report: successful induction of buprenorphine/naloxone using a microdosing schedule and assertive outreach. Addict Sci Clin Pract. 2020;15(1):2.PubMedPubMedCentralCrossRef Rozylo J, et al. Case report: successful induction of buprenorphine/naloxone using a microdosing schedule and assertive outreach. Addict Sci Clin Pract. 2020;15(1):2.PubMedPubMedCentralCrossRef
66.
Zurück zum Zitat Crane K, et al. Intravenous buprenorphine micro-dosing induction in a patient on methadone treatment: a case report. Psychosomatics. 2020. Crane K, et al. Intravenous buprenorphine micro-dosing induction in a patient on methadone treatment: a case report. Psychosomatics. 2020.
67.
Zurück zum Zitat • Moe J, et al. Short communication: systematic review on effectiveness of micro-induction approaches to buprenorphine initiation. Addict Behav. 2021;114:106740 A systematic review on effectiveness of microdosing when initiating or opioid rotating to buprenorphine.PubMedCrossRef • Moe J, et al. Short communication: systematic review on effectiveness of micro-induction approaches to buprenorphine initiation. Addict Behav. 2021;114:106740 A systematic review on effectiveness of microdosing when initiating or opioid rotating to buprenorphine.PubMedCrossRef
68.
Zurück zum Zitat Lee DS, et al. Rapid induction of buprenorphine/naloxone for chronic pain using a microdosing regimen: a case report. A A Pract. 2020;14(2):44–7.PubMedPubMedCentralCrossRef Lee DS, et al. Rapid induction of buprenorphine/naloxone for chronic pain using a microdosing regimen: a case report. A A Pract. 2020;14(2):44–7.PubMedPubMedCentralCrossRef
69.
Zurück zum Zitat Klaire S, et al. Rapid micro-induction of buprenorphine/naloxone for opioid use disorder in an inpatient setting: a case series. Am J Addict. 2019;28(4):262–5.PubMedCrossRef Klaire S, et al. Rapid micro-induction of buprenorphine/naloxone for opioid use disorder in an inpatient setting: a case series. Am J Addict. 2019;28(4):262–5.PubMedCrossRef
70.
Zurück zum Zitat U.S. Department of Health and Human Services. Pain Management Best Practices Inter-Agency Task Force Report: updates, gaps, inconsistencies, and recommendations. 2019. U.S. Department of Health and Human Services. Pain Management Best Practices Inter-Agency Task Force Report: updates, gaps, inconsistencies, and recommendations. 2019.
71.
Zurück zum Zitat Dahan A, et al. Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats. Br J Anaesth. 2005;94(6):825–34.PubMedCrossRef Dahan A, et al. Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats. Br J Anaesth. 2005;94(6):825–34.PubMedCrossRef
72.
Zurück zum Zitat Yoshikawa A, et al. Opioid use and the risk of falls, fall injuries and fractures among older adults: a systematic review and meta-analysis. J Gerontol Ser A. 2020;75(10):1989–95.CrossRef Yoshikawa A, et al. Opioid use and the risk of falls, fall injuries and fractures among older adults: a systematic review and meta-analysis. J Gerontol Ser A. 2020;75(10):1989–95.CrossRef
73.•
Zurück zum Zitat Davis MP. Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain. J Support Oncol. 2012;10(6):209–19. A user-friendly review that may be used to submit to insurance companies to make the case for them to provide coverage for buprenorphine.PubMedCrossRef Davis MP. Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain. J Support Oncol. 2012;10(6):209–19. A user-friendly review that may be used to submit to insurance companies to make the case for them to provide coverage for buprenorphine.PubMedCrossRef
74.••
Zurück zum Zitat Pergolizzi J, et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an international expert panel with focus on the six clinically most often used World Health Organization step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract. 2008;8(4):287–313. A consensus panel that recommends using buprenorphine as first-line opioid analgesic for the elderly.PubMedCrossRef Pergolizzi J, et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an international expert panel with focus on the six clinically most often used World Health Organization step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract. 2008;8(4):287–313. A consensus panel that recommends using buprenorphine as first-line opioid analgesic for the elderly.PubMedCrossRef
75.
Zurück zum Zitat Giacomuzzi S, et al. Driving impairment on buprenorphine and slow-release oral morphine in drug-dependent patients. Forensic Sci Int. 2005;152(2):323–4.PubMedCrossRef Giacomuzzi S, et al. Driving impairment on buprenorphine and slow-release oral morphine in drug-dependent patients. Forensic Sci Int. 2005;152(2):323–4.PubMedCrossRef
76.
Zurück zum Zitat Kapil RP, et al. Once-weekly transdermal buprenorphine application results in sustained and consistent steady-state plasma levels. J Pain Symptom Manag. 2013;46(1):65–75.CrossRef Kapil RP, et al. Once-weekly transdermal buprenorphine application results in sustained and consistent steady-state plasma levels. J Pain Symptom Manag. 2013;46(1):65–75.CrossRef
77.
Zurück zum Zitat Al-Tawil N, et al. Pharmacokinetics of transdermal buprenorphine patch in the elderly. Eur J Clin Pharmacol. 2013;69(2):143–9.PubMedCrossRef Al-Tawil N, et al. Pharmacokinetics of transdermal buprenorphine patch in the elderly. Eur J Clin Pharmacol. 2013;69(2):143–9.PubMedCrossRef
78.
Zurück zum Zitat Griessinger N, Sittl R, Likar R. Transdermal buprenorphine in clinical practice--a post-marketing surveillance study in 13,179 patients. Curr Med Res Opin. 2005;21(8):1147–56.PubMedCrossRef Griessinger N, Sittl R, Likar R. Transdermal buprenorphine in clinical practice--a post-marketing surveillance study in 13,179 patients. Curr Med Res Opin. 2005;21(8):1147–56.PubMedCrossRef
79.
Zurück zum Zitat Hirst A, et al. Tramadol and the risk of fracture in an elderly female population: a cost utility assessment with comparison to transdermal buprenorphine. Eur J Health Econ. 2016;17(2):217–27.PubMedCrossRef Hirst A, et al. Tramadol and the risk of fracture in an elderly female population: a cost utility assessment with comparison to transdermal buprenorphine. Eur J Health Econ. 2016;17(2):217–27.PubMedCrossRef
80.
Zurück zum Zitat Acampora GA, Nisavic M, Zhang Y. Perioperative buprenorphine continuous maintenance and administration simultaneous with full opioid agonist: patient priority at the interface between medical disciplines. J Clin Psychiatry. 2020;81(1). Acampora GA, Nisavic M, Zhang Y. Perioperative buprenorphine continuous maintenance and administration simultaneous with full opioid agonist: patient priority at the interface between medical disciplines. J Clin Psychiatry. 2020;81(1).
81.
Zurück zum Zitat Sporer KA. Buprenorphine: a primer for emergency physicians. Ann Emerg Med. 2004;43(5):580–4.PubMedCrossRef Sporer KA. Buprenorphine: a primer for emergency physicians. Ann Emerg Med. 2004;43(5):580–4.PubMedCrossRef
82.
Zurück zum Zitat Greenwald MK, et al. Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers. Neuropsychopharmacology. 2003;28(11):2000–9.PubMedCrossRef Greenwald MK, et al. Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers. Neuropsychopharmacology. 2003;28(11):2000–9.PubMedCrossRef
83.
Zurück zum Zitat Penza P, et al. Short- and intermediate-term efficacy of buprenorphine TDS in chronic painful neuropathies. J Peripher Nerv Syst. 2008;13(4):283–8.PubMedCrossRef Penza P, et al. Short- and intermediate-term efficacy of buprenorphine TDS in chronic painful neuropathies. J Peripher Nerv Syst. 2008;13(4):283–8.PubMedCrossRef
84.
Zurück zum Zitat Walsh SL, et al. Acute administration of buprenorphine in humans: partial agonist and blockade effects. J Pharmacol Exp Ther. 1995;274(1):361–72.PubMed Walsh SL, et al. Acute administration of buprenorphine in humans: partial agonist and blockade effects. J Pharmacol Exp Ther. 1995;274(1):361–72.PubMed
Metadaten
Titel
Treating Chronic Pain with Buprenorphine—The Practical Guide
verfasst von
Amy A. Case
Justin Kullgren
Sidra Anwar
Sandra Pedraza
Mellar P. Davis
Publikationsdatum
01.12.2021
Verlag
Springer US
Erschienen in
Current Treatment Options in Oncology / Ausgabe 12/2021
Print ISSN: 1527-2729
Elektronische ISSN: 1534-6277
DOI
https://doi.org/10.1007/s11864-021-00910-8

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