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15.12.2018 | Original Article

TREM-1 modulation produces positive outcome on the histopathology and cytokines release profile of Plasmodium berghei-infected mice

verfasst von: Voon Kin Chin, Afiq Mohd Yusof Asyran, Zainul Amiruddin Zakaria, Wan Omar Abdullah, Pei Pei Chong, Norshariza Nordin, Zaid Osamah Ibraheem, Roslaini Abdul Majid, Rusliza Basir

Erschienen in: Journal of Parasitic Diseases | Ausgabe 1/2019

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Abstract

Triggering receptor expressed on myeloid cells 1 (TREM-1) is a potential molecular therapeutic target for various inflammatory diseases. Despite that, the role of TREM-1 during malaria pathogenesis remains obscure with present literature suggesting a link between TREM-1 with severe malaria development. Therefore, this study aims to investigate the role of TREM-1 and TREM-1 related drugs during severe malaria infection in Plasmodium berghei-infected mice model. Our findings revealed that TREM-1 concentration was significantly increased throughout the infection periods and TREM-1 was positively correlated with malaria parasitemia development. This suggests a positive involvement of TREM-1 in severe malaria development. Meanwhile, blocking of TREM-1 activation using rmTREM-1/Fc and TREM-1 clearance by mTREM-1/Ab had significantly reduced malaria parasitemia and suppressed the production of pro- inflammatory cytokines (TNF-α, IL-6 and IFN-γ) and anti-inflammatory cytokine (IL-10). Furthermore, histopathological analysis of TREM-1 related drug treatments, in particular rmTREM-1/Fc showed significant improvements in the histological conditions of major organs (kidneys, spleen, lungs, liver and brain) of Plasmodium berghei-infected mice. This study showed that modulation of TREM-1 released during malaria infection produces a positive outcome on malaria infection through inhibition of pro-inflammatory cytokines secretion and alleviation of histopathological conditions of affected organs. Nevertheless, further investigation on its optimal dosage and dose dependant study should be carried out to maximise its full potential as immunomodulatory or as an adjuvant in line with current antimalarial agents.

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Titel: TREM-1 modulation produces positive outcome on the histopathology and cytokines release profile of Plasmodium berghei-infected mice
verfasst von: Voon Kin Chin
Afiq Mohd Yusof Asyran
Zainul Amiruddin Zakaria
Wan Omar Abdullah
Pei Pei Chong
Norshariza Nordin
Zaid Osamah Ibraheem
Roslaini Abdul Majid
Rusliza Basir
Publikationsdatum: 15.12.2018
Verlag: Springer India
Erschienen in: Journal of Parasitic Diseases / Ausgabe 1/2019
Print ISSN: 0971-7196
Elektronische ISSN: 0975-0703
DOI: https://doi.org/10.1007/s12639-018-1070-3

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