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01.01.2014 | Original Article

Tumor blood flow change measured by CT perfusion during chemoradiation therapy (CRT) for monitoring response and predicting survival in patients with esophageal cancer

verfasst von: Koichi Hayano, Kiyohiko Shuto, Asami Satoh, Tomoyoshi Aoyagi, Kazuo Narushima, Hisashi Gunji, Tsuguaki Kono, Noriyuki Yanagawa, Shinichi Okazumi, Hisahiro Matsubara

Erschienen in: Esophagus | Ausgabe 1/2014

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Abstract

Background

The purpose of this study is to evaluate whether computed tomography perfusion (CTP) can evaluate the biological change during chemoradiation therapy (CRT) and the survival of patients with esophageal cancer after CRT.

Methods

Thirty-two consecutive patients (31 men, 1 woman; mean age 65.9 years) with esophageal squamous cell carcinoma underwent CTP before and 2–3 weeks after CRT. The perfusion data were analyzed using software based on the deconvolution method. We investigated the relationship between the changes of CTP parameters during CRT, the response to CRT and outcome.

Results

This study included 22 clinical responders and 10 non-responders. Post-CRT blood flow (BF) was significantly lower than pre-CRT (P = 0.0003). BF in responders decreased significantly greater than in non-responders (P < 0.0001). Patients whose tumors showed a greater reduction (greater than 15 % reduction) in BF during CRT survived significantly longer than those with lower tumor BF reduction (P = 0.03).

Conclusions

Substantial BF change may help to evaluate the response to CRT and survival in patients with advanced esophageal squamous cell carcinoma.

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Titel: Tumor blood flow change measured by CT perfusion during chemoradiation therapy (CRT) for monitoring response and predicting survival in patients with esophageal cancer
verfasst von: Koichi Hayano
Kiyohiko Shuto
Asami Satoh
Tomoyoshi Aoyagi
Kazuo Narushima
Hisashi Gunji
Tsuguaki Kono
Noriyuki Yanagawa
Shinichi Okazumi
Hisahiro Matsubara
Publikationsdatum: 01.01.2014
Verlag: Springer Japan
Erschienen in: Esophagus / Ausgabe 1/2014
Print ISSN: 1612-9059
Elektronische ISSN: 1612-9067
DOI: https://doi.org/10.1007/s10388-013-0400-x

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Abstract

Background

Methods

Results

Conclusions

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