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European Journal of Nuclear Medicine and Molecular Imaging

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01.07.2014 | Original Article

Tumor hypoxia and microscopic diffusion capacity in brain tumors: A comparison of ⁶²Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET/CT and diffusion-weighted MR imaging

verfasst von: Ayako Hino-Shishikura, Ukihide Tateishi, Hirofumi Shibata, Tomohiro Yoneyama, Toshiaki Nishii, Ikuo Torii, Kensuke Tateishi, Makoto Ohtake, Nobutaka Kawahara, Tomio Inoue

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 7/2014

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Abstract

Objectives

The aim of this study was to clarify the relationship between tumor hypoxia and microscopic diffusion capacity in primary brain tumors using ⁶²Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) (⁶²Cu-ATSM) PET/CT and diffusion-weighted MR imaging (DWI).

Methods

This study was approved by the institutional human research committee and was HIPAA compliant, and informed consent was obtained from all patients. ⁶²Cu-ATSM PET/CT and DWI were performed in a total of 40 primary brain tumors of 34 patients with low grade glioma (LGG, n = 13), glioblastoma (GBM, n = 20), and primary central nervous system lymphoma (PCNSL, n = 7). ⁶²Cu-ATSM PET/CT parameters and apparent diffusion coefficient (ADC) obtained by DWI were compared.

Results

High intensity signals by ⁶²Cu-ATSM PET/CT and DWI in patients with GBM and PCNSL, and low intensity signals in LGG patients were observed. An inverse correlation was found between maximum SUV (SUV_max) and minimum ADC (ADC_min) (r = −0.583, p < 0.0001), and between tumor/brain ratio (T/B_ratio) and ADC_min for all tumors (r = −0.532, p < 0.0001). Both SUV_max and T/B_ratio in GBM were higher than LGG (p < 0.0001 and p < 0.0001), and those in PCNSL were also higher than GBM (p = 0.033 and p = 0.044). The ADC_min was lower in GBM (p = 0.011) and PCNSL (p = 0.01) than in LGG, while no significant difference was found between GBM and PCNSL (p = 0.90).

Conclusion

Tumor hypoxia assessed by ⁶²Cu-ATSM PET/CT correlated with microscopic diffusion capacity obtained by DWI in brain tumors. Both ⁶²Cu-ATSM PET/CT and DWI were considered feasible imaging methods for grading glioma. However, ⁶²Cu-ATSM PET/CT provided additional diagnostic information to differentiate between GBM and PCNSL.

Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 1996;379:88–91.PubMedCrossRef

Shweiki D, Itin A, Soffer D, et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992;359:843–5.PubMedCrossRef

Jensen RL. Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J Neurooncol. 2009;92:317–35.PubMedCrossRef

Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986;161:401–7.PubMed

Warach S, Chien D, Li W, Ronthal M, et al. Fast magnetic resonance diffusion-weighted imaging of acute human stroke. Neurology. 1992;42:1717–23.PubMedCrossRef

Pierpaoli C, Righini A, Linfante I, et al. Histopathologic correlates of abnormal water diffusion in cerebral ischemia: diffusion-weighted MR imaging and light and electron microscopic study. Radiology. 1993;189:439–48.PubMed

Khayal IS, Vandenberg SR, Smith KJ, et al. MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas. Neuro Oncol. 2011;13:1192–201.PubMedCentralPubMedCrossRef

Murakami R, Hirai T, Sugahara T, et al. Grading astrocytic tumors by using apparent diffusion coefficient parameters: superiority of a one- versus two-parameter pilot method. Radiology. 2009;251:838–45.PubMedCrossRef

Barajas Jr RF, Rubenstein JL, Chang JS, et al. Diffusion-weighted MR imaging derived apparent diffusion coefficient is predictive of clinical outcome in primary central nervous system lymphoma. Am J Neuroradiol. 2010;31:60–6.PubMedCentralPubMedCrossRef

10.

Higano S, Yun X, Kumabe T, et al. Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis. Radiology. 2006;241:839–46.PubMedCrossRef

11.

Hoigebazar L, Jeong JM. Hypoxia imaging agents labeled with positron emitters. Recent results. Cancer Res. 2012;194:285–99.

12.

Fujibayashi Y, Taniuchi H, Yonekura Y, et al. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med. 1997;38:1155–60.PubMed

13.

Imam SK. Review of positron emission tomography tracers for imaging of tumor hypoxia. Cancer Biother Radiopharm. 2010;25:365–74.PubMedCrossRef

14.

Wen B, Burgman P, Zanzonico P, et al. A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia. Eur J Nucl Med Mol Imaging. 2004;31:1530–8.PubMedCrossRef

15.

Nunn A, Linder K, Strauss HW. Nitroimidazoles and imaging hypoxia. Eur J Nucl Med. 1995;22:265–80.PubMedCrossRef

16.

Martin GV, Caldwell JH, Graham MM, et al. Noninvasive detection of hypoxic myocardium using fluorine-18-fluoromisonidazole and positron emission tomography. J Nucl Med. 1992;33:2202–8.PubMed

17.

Sheehan JP, Popp B, Monteith S, et al. Trans sodium crocetinate: functional neuroimaging studies in a hypoxic brain tumor. J Neurosurg. 2011;115:749–53.PubMedCrossRef

18.

Lewis JS, Sharp TL, Laforest R, et al. Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): effect of changes in tissue oxygenation. J Nucl Med. 2001;42:655–61.PubMed

19.

Tateishi K, Tateishi U, Sato M, et al. Application of 62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET imaging to predict highly malignant tumor grades and hypoxia-inducible factor-1alpha expression in patients with glioma. Am J Neuroradiol. 2012;34:92–9.PubMedCrossRef

20.

Brat DJ, Van Meir EG. Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma. Lab Invest. 2004;84:397–405.PubMedCrossRef

21.

Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97–109.PubMedCentralPubMedCrossRef

22.

Fujibayashi Y, Cutler CS, Anderson CJ, et al. Comparative studies of Cu-64-ATSM and C-11-acetate in an acute myocardial infarction model: ex vivo imaging of hypoxia in rats. Nucl Med Biol. 1999;26:117–21.PubMedCrossRef

23.

Read SJ, Jackson GD, Abbott DF, et al. Experience with diffusion-weighted imaging in an acute stroke unit. Cerebrovasc Dis. 1998;8:135–43.PubMedCrossRef

24.

Lewis JS, McCarthy DW, Welch MJ, et al. Evaluation of 64Cu-ATSM in vitro and in vivo in a tumor model. J Nucl Med. 1999;40:177–83.PubMed

25.

Yuan H, Schroeder T, Bowsher JE, Dewhirst MW, et al. Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med. 2006;47:989–98.PubMed

26.

Schlegel U, Schmidt-Wolf IG, Deckert M. Primary CNS lymphoma: clinical presentation, pathological classification, molecular pathogenesis and treatment. J Neurol Sci. 2000;181:1–12.PubMedCrossRef

27.

Barlow CH, Harken AH, Chance B. Evaluation of cardiac ischemia by NADH fluroescence photography. Ann Surg. 1977;186:737–40.PubMedCentralPubMedCrossRef

28.

Guo AC, Cummings TJ, Dash RC, et al. Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology. 2002;224:177–83.PubMedCrossRef

29.

Matsushima N, Maeda M, Umino M, et al. Relation between FDG uptake and apparent diffusion coefficients in glioma and malignant lymphoma. Ann Nucl Med. 2012;26:262–71.PubMedCrossRef

30.

Buchbender C, Heusner TA, Lauenstein C, et al. Oncologic PET/MRI, Part 1: tumor of the brain, head and neck, chest, abdomen, and pelvis. J Nucl Med. 2012;53:928–38.PubMedCrossRef

31.

Buchbender C, Heusner TA, Lauenstein C, et al. Oncologic PET/MRI, Part 2: bone tumors, soft-tissue tumors, melanoma, and lymphoma. J Nucl Med. 2012;53:1244–52.PubMedCrossRef

Titel: Tumor hypoxia and microscopic diffusion capacity in brain tumors: A comparison of 62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET/CT and diffusion-weighted MR imaging
verfasst von: Ayako Hino-Shishikura
Ukihide Tateishi
Hirofumi Shibata
Tomohiro Yoneyama
Toshiaki Nishii
Ikuo Torii
Kensuke Tateishi
Makoto Ohtake
Nobutaka Kawahara
Tomio Inoue
Publikationsdatum: 01.07.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 7/2014
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-014-2714-x

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusion

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