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Journal of Neurology

Erschienen in:

01.06.2011 | Review

Tumor necrosis factor-alpha as a potential therapeutic target in idiopathic inflammatory myopathies

verfasst von: Joerg-Patrick Stübgen

Erschienen in: Journal of Neurology | Ausgabe 6/2011

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Abstract

The cytokine, tumor necrosis factor alpha (TNFα), has been implicated in many aspects of immune system development, immune response regulation, and T cell-mediated tissue injury. TNFα plays a less well-defined role in the pathogenesis of the idiopathic inflammatory myopathy (IIM) group of disorders, and has been considered a potential therapeutic target. Observational studies of TNFα-blockade in (mostly refractory) IIM have yielded inconsistent beneficial results so that administration of these biological agents is presently deemed an unreliable alternative treatment strategy. Moreover, anti-TNFα therapy has the rare potential to trigger myositis in patients with rheumatoid arthritis, hinting at a pre-existing “overlap disorder”. The full potential of TNFα-antagonism will be realized only if randomized controlled trials ascertain appropriate treatment regimens and identify patient subgroups most likely to benefit from such therapy.

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Titel: Tumor necrosis factor-alpha as a potential therapeutic target in idiopathic inflammatory myopathies
verfasst von: Joerg-Patrick Stübgen
Publikationsdatum: 01.06.2011
Verlag: Springer-Verlag
Erschienen in: Journal of Neurology / Ausgabe 6/2011
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-011-5907-2

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