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European Archives of Oto-Rhino-Laryngology

Erschienen in:

23.10.2020 | Head and Neck

Tumor volume as a prognostic factor of locally advanced laryngeal cancer

verfasst von: Natália Martins Magacho de Andrade, Rogério Aparecido Dedivitis, Daniel Marin Ramos, Leandro Luongo Matos, Marcio Ricardo Taveira Garcia, Gustavo Gonçalves Conti, Luiz Paulo Kowalski

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2021

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Abstract

Purpose

The TNM tumor staging system is the most widely used for laryngeal cancer. However, in the same T stage, lesions with different primary tumor volumes (TV) can be found, impacting treatment outcomes.

Methods

145 patients with T3 and T4a laryngeal cancer, according to Union for International Cancer Control, who underwent surgical treatment from 2008 to 2017, were analyzed. TV measurements were collected and compared to different outcomes.

Results

The mean TV was 23.0 ± 16.4 cm³. A cutoff point for TV of 14.2 cm³ was established. Cumulative sample 5-year overall survival (OS) was 62.1%, while 5-years disease-free survival (DFS) was 65.5%. In univariate analysis, TV ≥ 14.2 cm³ was associated with a higher risk of distant metastases (p = 0.045), and worse rates of OS (p = 0.009) and DFS (p = 0.035). In multivariate analysis, TV was not an independent risk factor of worse DFS (p = 0.569) or OS (p = 0.094).

Conclusion

Primary lesion TV showed significant association, in univariate analysis, with worse rates of recurrence and survival in advanced laryngeal cancer undergoing surgical treatment and can be a promising prognostic for these patients.

Instituto Nacional do Câncer - INCA [Internet]. Câncer de Laringe [updated 2020 Aug 20; cited 2020 Aug 28]. Available from: https://www.inca.gov.br/tipos-de-cancer/cancer-de-laringe.

Freeman DE, Mancuso AA, Parsons JT, Mendenhall WM, Million RR (1990) Irradiation alone for supraglottic larynx carcinoma: can CT findings predict treatment results? Int J Radiat Oncol Biol Phys 19(2):485–490CrossRef

Mendenhall WM, Mancuso AA, Strojan P et al (2014) Impact of primary tumor volume on local control after definitive radiotherapy for head and neck cancer. Head Neck 36(9):1363–1367PubMed

Timmermans AJ, Lange CAH, de Bois JA et al (2016) Tumor volume as a prognostic factor for local control and overall survival in advanced larynx cancer. Laryngoscope 126(2):E60–E67CrossRef

Strongin A, Yovino S, Taylor R et al (2012) Primary tumor volume is an important predictor of clinical outcomes among patients with locally advanced squamous cell cancer of the head and neck treated with definitive chemoradiotherapy. Int J Radiat Oncol Biol Phys 82(5):1823–1830CrossRef

Chufal KS, Rastogi M, Srivastava M, Pant MC, Bhatt MLB, Srivastava K (2006) Analysis of prognostic variables among patients with locally advanced head and neck cancer treated with late chemo-intensification protocol: impact of nodal density and total tumor volume. Jpn J Clin Oncol 36(9):537–546CrossRef

Johnson CR, Khandelwal SR, Schmidt-Ullrich RK, Ravalese J, Wazer DE (1995) The influence of quantitative tumor volume measurements on local control in advanced head and neck cancer using concomitant boost accelerated superfractionated irradiation. Int J Radiat Oncol Biol Phys 32(3):635–641CrossRef

Chen S-W, Yang S-N, Liang J-A, Tsai M-H, Shiau A-C, Lin F-J (2006) Value of computed tomography-based tumor volume as a predictor of outcomes in hypopharyngeal cancer after treatment with definitive radiotherapy. Laryngoscope 116(11):2012–2017CrossRef

Blitz A, Aygun N (2008) Radiologic evaluation of larynx cancer. Otolaryngol Clin N Am 1:697–713CrossRef

10.

Fletcher G (1966) Textbook of radiotherapy. Lea, Febiger

11.

Kurek R, Kalogera-Fountzila A, Muskalla K et al (2003) Usefulness of tumor volumetry as a prognostic factor of survival in head and neck cancer. Strahlenther Onkol Organ Dtsch Rontgengesellschaft Al 179(5):292–297CrossRef

12.

Mukherji SK, Toledano AY, Beldon C et al (2005) Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma. Cancer 103(12):2616–2622CrossRef

13.

Rutkowski T (2014) Impact of initial tumor volume on radiotherapy outcome in patients with T2 glottic cancer. Strahlenther Onkol Organ Dtsch Rontgengesellschaft Al 190(5):480–484CrossRef

14.

van Bockel LW, Monninkhof EM, Pameijer FA, Terhaard CHJ (2013) Importance of tumor volume in supraglottic and glottic laryngeal carcinoma. Strahlenther Onkol Organ Dtsch Rontgengesellschaft Al 189(12):1009–1014CrossRef

15.

Shiao JC, Mohamed ASR, Messer JA et al (2017) Quantitative pretreatment CT volumetry: association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx. Head Neck 39(8):1609–1620CrossRef

16.

Rutkowski T, Wygoda A, Składowski K et al (2013) Prognostic role of tumor volume for radiotherapy outcome in patient with T2 laryngeal cancer. Strahlenther Onkol Organ Dtsch Rontgengesellschaft Al 189(10):861–866CrossRef

17.

Hermans R, Van den Bogaert W, Rijnders A, Baert AL (1999) Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys 44(4):755–765CrossRef

18.

Yang C-J, Kim D-Y, Lee JH et al (2013) Prognostic value of total tumor volume in advanced-stage laryngeal and hypopharyngeal carcinoma. J Surg Oncol 108(8):509–515CrossRef

19.

Hsin L-J, Fang T-J, Tsang N-M et al (2014) Tumor volumetry as a prognostic factor in the management of T4a laryngeal cancer. Laryngoscope 124(5):1134–1140CrossRef

20.

Lefebvre JL (2006) Laryngeal preservation in head and neck cancer: multidisciplinary approach. Lancet Oncol 7(9):747–755CrossRef

21.

Stenson KM, Maccracken E, Kunnavakkam R et al (2012) Chemoradiation for patients with large-volume laryngeal cancers. Head Neck 34(8):1162–1167CrossRef

22.

Chen AY, Halpern M (2007) Factors predictive of survival in advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg 133(12):1270–1276CrossRef

23.

Grover S, Swisher-McClure S, Mitra N et al (2015) Total Laryngectomy versus larynx preservation for T4a Larynx Cancer: patterns of care and survival outcomes. Int J Radiat Oncol Biol Phys 92(3):594–601CrossRef

24.

Knegjens JL, Hauptmann M, Pameijer FA et al (2011) Tumor volume as prognostic factor in chemoradiation for advanced head and neck cancer. Head Neck 33(3):375–382PubMed

25.

Narayan K, Fisher R, Bernshaw D (2006) Significance of tumor volume and corpus uteri invasion in cervical cancer patients treated by radiotherapy. Int J Gynecol Cancer Off J Int Gynecol Cancer Soc 16(2):623–630CrossRef

26.

Basaki K, Abe Y, Aoki M, Kondo H, Hatayama Y, Nakaji S (2006) Prognostic factors for survival in stage III non-small-cell lung cancer treated with definitive radiation therapy: impact of tumor volume. Int J Radiat Oncol Biol Phys 64(2):449–454CrossRef

27.

Lodder WL, Pameijer FA, Rasch CRN et al (2012) Prognostic significance of radiologically determined neck node volume in head and neck cancer: a systematic review. Oral Oncol 48(4):298–302CrossRef

28.

Hoebers FJP, Pameijer FA, de Bois J et al (2008) Prognostic value of primary tumor volume after concurrent chemoradiation with daily low-dose cisplatin for advanced-stage head and neck carcinoma. Head Neck 30(9):1216–1223CrossRef

29.

Plataniotis GA, Theofanopoulou M-E, Kalogera-Fountzila A et al (2004) Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial. Int J Radiat Oncol Biol Phys 59(4):1018–1026CrossRef

30.

Doweck I, Denys D, Robbins KT (2002) Tumor volume predicts outcome for advanced head and neck cancer treated with targeted chemoradiotherapy. The Laryngoscope 112(10):1742–1749CrossRef

31.

Dejaco D, Steinbichler T, Schartinger VH et al (2018) Prognostic value of tumor volume in patients with head and neck squamous cell carcinoma treated with primary surgery. Head Neck 40(4):728–739CrossRef

32.

Gorphe P, Tao Y, Blanchard P, Even C et al (2017) Relationship between the time to locoregional recurrence and survival in laryngeal squamous-cell carcinoma. Eur Arch Otorhinolaryngol 274(5):2267–2271CrossRef

33.

Ryu IS, Lee JH, Roh J-L et al (2015) Clinical implication of computed tomography findings in patients with locally advanced squamous cell carcinoma of the larynx and hypopharynx. Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto Rhino Laryngol Head Neck Surg 272(10):2939–2945

34.

Salesiotis AN, Cullen KJ (2000) Molecular markers predictive of response and prognosis in the patient with advanced squamous cell carcinoma of the head and neck: evolution of a model beyond TNM staging. Curr Opin Oncol 12(3):229–239CrossRef

35.

Pameijer FA, Balm AJM, Hilgers FJM et al (1997) Variability of tumor volumes in T3-staged head and neck tumors. Head Neck 19(1):6–13CrossRef

36.

Studer G, Lütolf UM, El-Bassiouni M, Rousson V, Glanzmann C (2007) Volumetric staging (VS) is superior to TNM and AJCC staging in predicting outcome of head and neck cancer treated with IMRT. Acta Oncol 46(3):386–394CrossRef

37.

Preda L, Lovati E, Chiesa F et al (2007) Measurement by multidetector CT scan of the volume of hypopharyngeal and laryngeal tumours: accuracy and reproducibility. Eur Radiol 17(8):2096–2102CrossRef

38.

Hermans R, Feron M, Bellon E, Dupont P, Van den Bogaert W, Baert AL (1998) Laryngeal tumor volume measurements determined with CT: A study on intra- and interobserver variability. Int J Radiat Oncol 40(3):553–557CrossRef

Titel: Tumor volume as a prognostic factor of locally advanced laryngeal cancer
verfasst von: Natália Martins Magacho de Andrade
Rogério Aparecido Dedivitis
Daniel Marin Ramos
Leandro Luongo Matos
Marcio Ricardo Taveira Garcia
Gustavo Gonçalves Conti
Luiz Paulo Kowalski
Publikationsdatum: 23.10.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2021
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06438-1

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Tumor volume as a prognostic factor of locally advanced laryngeal cancer