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Erschienen in: Archives of Gynecology and Obstetrics 5/2014

01.05.2014 | Gynecologic Endocrinology and Reproductive Medicine

Twice-daily dosing of gonadotropins does not improve embryo quality during in vitro fertilization cycles in women with polycystic ovary syndrome, when compared to once-daily dosing: a pilot study

verfasst von: Michael H. Dahan, Ruth B. Lathi

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2014

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Abstract

Purpose

To determine whether overexpression of the FSH receptor in polycystic ovary syndrome (PCOS) results in a relative deficiency of gonadotropins and poor oocyte and embryo quality during in vitro fertilization (IVF) cycles. Whether twice-daily dosing of gonadotropins could therefore result in improved embryo quality, by fixing this hypothesized relative deficiency of gonadotropins.

Method

Embryos generated at a university-based fertility center in women with PCOS were compared from twice-daily dosing to once-daily dosing of gonadotropins during IVF cycles. Oocyte and embryo quality was compared. A single patient’s embryos were included in the analysis from only one IVF cycle and all embryos from that cycle were included. 254 embryos were compared.

Results

Twice-daily vs. once-daily dosing of gonadotropins does not improve embryo or oocyte quality in women with PCOS.

Conclusions

The defect in response to gonadotropins in PCOS is most likely due to an inherent defect in the ovary and not a relative deficiency of gonadotropins due to overexpression of the FSH receptors. More studies are needed to confirm this finding.
Literatur
1.
Zurück zum Zitat Erickson GF, Magoffin DA, Garzo VG, Cheung AP, Chang RJ (1992) Granulosa cells of polycystic ovaries: are they normal or abnormal? Hum Reprod 7(3):293–299PubMed Erickson GF, Magoffin DA, Garzo VG, Cheung AP, Chang RJ (1992) Granulosa cells of polycystic ovaries: are they normal or abnormal? Hum Reprod 7(3):293–299PubMed
2.
Zurück zum Zitat Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ (2003) Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88(4):1742–1747PubMedCrossRef Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ (2003) Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88(4):1742–1747PubMedCrossRef
3.
Zurück zum Zitat Erickson GF, Magoffin DA, Cragun JR, Chang RJ (1990) The effects of insulin and insulin-like growth factors-I and -II on estradiol production by granulosa cells of polycystic ovaries. J Clin Endocrinol Metab 70(4):894–902PubMedCrossRef Erickson GF, Magoffin DA, Cragun JR, Chang RJ (1990) The effects of insulin and insulin-like growth factors-I and -II on estradiol production by granulosa cells of polycystic ovaries. J Clin Endocrinol Metab 70(4):894–902PubMedCrossRef
4.
Zurück zum Zitat Erickson GF, Garzo VG, Magoffin DA (1989) Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells. J Clin Endocrinol Metab 69(4):716–724PubMedCrossRef Erickson GF, Garzo VG, Magoffin DA (1989) Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells. J Clin Endocrinol Metab 69(4):716–724PubMedCrossRef
5.
Zurück zum Zitat Barnes RB, Rosenfield RL, Burstein S, Ehrmann DA (1989) Pituitary–ovarian responses to nafarelin testing in the polycystic ovary syndrome. N Engl J Med 320(9):559–565PubMedCrossRef Barnes RB, Rosenfield RL, Burstein S, Ehrmann DA (1989) Pituitary–ovarian responses to nafarelin testing in the polycystic ovary syndrome. N Engl J Med 320(9):559–565PubMedCrossRef
6.
Zurück zum Zitat Almahbobi G, Anderiesz C, Hutchinson P, McFarlane JR, Wood C, Trounson AO (1996) Functional integrity of granulosa cells from polycystic ovaries. Clin Endocrinol (Oxf) 44(5):571–580CrossRef Almahbobi G, Anderiesz C, Hutchinson P, McFarlane JR, Wood C, Trounson AO (1996) Functional integrity of granulosa cells from polycystic ovaries. Clin Endocrinol (Oxf) 44(5):571–580CrossRef
7.
Zurück zum Zitat Weil SJ, Vendola K, Zhou J, Adesanya OO, Wang J, Okafor J, Bondy CA (1998) Androgen receptor gene expression in the primate ovary: cellular localization, regulation, and functional correlations. J Clin Endocrinol Metab 83(7):2479–2485PubMedCrossRef Weil SJ, Vendola K, Zhou J, Adesanya OO, Wang J, Okafor J, Bondy CA (1998) Androgen receptor gene expression in the primate ovary: cellular localization, regulation, and functional correlations. J Clin Endocrinol Metab 83(7):2479–2485PubMedCrossRef
8.
Zurück zum Zitat Hillier SG, De Zwart FA (1981) Evidence that granulosa cell aromatase induction/activation by follicle-stimulating hormone is an androgen receptor-regulated process in vitro. Endocrinology 109(4):1303–1305PubMedCrossRef Hillier SG, De Zwart FA (1981) Evidence that granulosa cell aromatase induction/activation by follicle-stimulating hormone is an androgen receptor-regulated process in vitro. Endocrinology 109(4):1303–1305PubMedCrossRef
9.
Zurück zum Zitat Harlow CR, Shaw HJ, Hillier SG, Hodges JK (1988) Factors influencing follicle-stimulating hormone-responsive steroidogenesis in marmoset granulosa cells: effects of androgens and the stage of follicular maturity. Endocrinology 122(6):2780–2787PubMedCrossRef Harlow CR, Shaw HJ, Hillier SG, Hodges JK (1988) Factors influencing follicle-stimulating hormone-responsive steroidogenesis in marmoset granulosa cells: effects of androgens and the stage of follicular maturity. Endocrinology 122(6):2780–2787PubMedCrossRef
10.
Zurück zum Zitat Pache TD, Chadha S, Gooren LJ, Hop WC, Jaarsma KW, Dommerholt HB, Fauser BC (1991) Ovarian morphology in long-term androgen-treated female to male transsexuals. A human model for the study of polycystic ovarian syndrome? Histopathology 19(5):445–452PubMedCrossRef Pache TD, Chadha S, Gooren LJ, Hop WC, Jaarsma KW, Dommerholt HB, Fauser BC (1991) Ovarian morphology in long-term androgen-treated female to male transsexuals. A human model for the study of polycystic ovarian syndrome? Histopathology 19(5):445–452PubMedCrossRef
11.
Zurück zum Zitat Pache TD, Fauser BC (1993) Polycystic ovaries in female-to-male transsexuals. Clin Endocrinol (Oxf) 39(6):702–703 Pache TD, Fauser BC (1993) Polycystic ovaries in female-to-male transsexuals. Clin Endocrinol (Oxf) 39(6):702–703
12.
Zurück zum Zitat Follitropins: Drug information, Copyright 1978–2006 Lexi-Comp in Up-to date on line version 14.3 Follitropins: Drug information, Copyright 1978–2006 Lexi-Comp in Up-to date on line version 14.3
13.
Zurück zum Zitat Ibanez L, Potau N, De Zegher F (1999) Endocrinology and metabolism after premature pubarche in girls. Acta Paediatr Suppl 88(433):73–77PubMed Ibanez L, Potau N, De Zegher F (1999) Endocrinology and metabolism after premature pubarche in girls. Acta Paediatr Suppl 88(433):73–77PubMed
Metadaten
Titel
Twice-daily dosing of gonadotropins does not improve embryo quality during in vitro fertilization cycles in women with polycystic ovary syndrome, when compared to once-daily dosing: a pilot study
verfasst von
Michael H. Dahan
Ruth B. Lathi
Publikationsdatum
01.05.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 5/2014
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-013-3095-2

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