Background
Methods
Study design and patient recruitment
Measurement of blood pressure and pulse wave analysis
Analysis of coronary angiography
Statistical analysis
Results
Patient demographics
Total (n = 197) | Non-diabetic (n = 113) | Diabetic (n = 84) | p-value | |
---|---|---|---|---|
Age(years) | 59.2 ± 11.1 | 57.9 ± 11.0 | 60.9 ± 11.0 | 0.069 |
Gender(male), n(%) | 142(72.1) | 82(72.6) | 59(70.2) | 0.646 |
Hypertension, n(%) | 128(65) | 67(59.3) | 61(72.6) | 0.063 |
Hyperlipidemia, n(%) | 45(22.8) | 21(18.6) | 24(28.6) | 0.106 |
Current smokers, n(%) | 101(51.3) | 59(52.2) | 41(48.8) | 0.592 |
BMI(kg/m2) | 25.2 ± 5.3 | 25.4 ± 4.9 | 25.1 ± 5.7 | 0.684 |
SYNTAX | 16.4 ± 12.2 | 16.0 ± 11.9 | 17.0 ± 12.6 | 0.546 |
SYNTAX > 22, n(%) | 60(30.5) | 35(31.3) | 25(29.8) | 0.823 |
Lab data | ||||
HbA1c(%) | 6.4 ± 1.2 | 5.7 ± 0.4 | 7.3 ± 1.3 | <0.3* |
Triglyceride(mmol/l) | 1.8 ± 1.6 | 1.6 ± 0.8 | 2.0 ± 1.8 | 0.073 |
LDL cholesterol(mmol/l) | 2.6 ± 1.0 | 2.6 ± 1.0 | 2.5 ± 1.0 | 0.775 |
HDL cholesterol(mmol/l) | 1.1 ± 0.3 | 1.1 ± 0.3 | 1.1 ± 0.3 | 0.045* |
Creatinine(μmol/l) | 79.0 ± 17.6 | 77.8 ± 17.5 | 80.6 ± 17.7 | 0.260* |
Medications | ||||
ACEI, n(%) | 21(10.7) | 11(9.7) | 10(11.9) | 0.641 |
ARB, n(%) | 17(8.6) | 6(5.3) | 11(13.1) | 0.057 |
β-blockers, n(%) | 35(17.8) | 21(18.6) | 14(16.7) | 0.706 |
Calcium channel blockers, n(%) | 44(22.3) | 14(12.4) | 30(35.7) | <0.3* |
Statins, n(%) | 32(16.2) | 10(8.8) | 22(26.2) | 0.9* |
Central hemodynamic indices analysis
Total (n = 197) | Non-diabetic (n = 113) | Diabetic (n = 84) | p-value | |
---|---|---|---|---|
SBP(mmHg) | 130.1 ± 17.3 | 127.8 ± 17.5 | 133.2 ± 16.6 | 0.037* |
DBP(mmHg) | 74.9 ± 11.1 | 74.8 ± 10.9 | 75.0 ± 11.5 | 0.884 |
CASP(mmHg) | 120.3 ± 16.6 | 118.1 ± 16.5 | 123.1 ± 16.5 | 0.044* |
MAP(mmHg) | 91.9 ± 12.1 | 91.3 ± 12.8 | 92.8 ± 11.2 | 0.387 |
AP(mmHg) | 11.8 ± 7.5 | 11.9 ± 7.3 | 11.7 ± 7.9 | 0.840 |
Central PP(mmHg) | 45.4 ± 13.0 | 43.5 ± 11.9 | 48.1 ± 13.9 | 0.130 |
Brachial PP(mmHg) | 55.2 ± 14.0 | 53.2 ± 13.2 | 58.1 ± 14.5 | 0.130 |
PR(bpm) | 67.7 ± 10.1 | 67.5 ± 10.3 | 67.8 ± 9.8 | 0.750 |
AIx(%) | 77.8 ± 14.5 | 77.0 ± 14.0 | 79.0 ± 15.0 | 0.372 |
AIx@75(%) | 74.9 ± 14.2 | 74.0 ± 14.3 | 76.1 ± 13.9 | 0.317 |
PRT(ms) | 114.5 ± 27.0 | 116.1 ± 28.1 | 112.5 ± 25.4 | 0.374 |
Variables | N | SYNTAX > 22, N(%) | Univariate analysis | Multivariate analysisa | ||
---|---|---|---|---|---|---|
Odds ratio(95 % CI) |
p
| Odds ratio(95 % CI) |
p
| |||
Total | 197 | 60(30.5) | ||||
AIx@75 | 1.035(1.011–1.059) | 0.004 | ||||
AP | 1.031(0.989–1.075) | 0.145 | ||||
PRT | 0.991(0.980–1.002) | 0.120 | ||||
Non-Diabetic | 113 | 35(31.3) | ||||
AIx@75 | 1.064(1.027–1.103) | 0.001 | 1.099(1.028–1.176) | 0.006 | ||
AP | 1.084(1.018–1.154) | 0.012 | 0.938(0.837–1.051) | 0.273 | ||
PRT | 0.985(0.971–1.000) | 0.044 | 1.002(0.984–1.021) | 0.800 | ||
Diabetic | 84 | 25(29.8) | ||||
AIx@75 | 1.002(0.969–1.037) | 0.885 | ||||
AP | 0.979(0.921–1.040) | 0.491 | ||||
PRT | 1.001(0.983–1.020) | 0.920 |