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Erschienen in: Die Urologie 11/2022

12.10.2022 | Leitthema

Umweltfaktoren, Lebensstil und männliche Fertilität

verfasst von: Prof. Dr. med. Hans-Christian Schuppe, Prof. Dr. med. Frank-Michael Köhn

Erschienen in: Die Urologie | Ausgabe 11/2022

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Zusammenfassung

Bei der Erfassung kausaler Faktoren männlicher Fertilitätsstörungen spielen Lebensstil und Umweltfaktoren eine wichtige Rolle. Das Wissen um die Wechselwirkungen zwischen derartigen Einflüssen und reproduktiven Funktionen des Mannes eröffnet zudem die Möglichkeit eines präventiven Ansatzes in der Andrologie. Relevante exogene Noxen sind Genussgifte, Pharmaka einschließlich Lifestyle-Medikamenten, Berufsstoffe, Umweltchemikalien sowie physikalische Faktoren. Reproduktionstoxische Effekte können sich prätestikulär, testikulär oder posttestikulär entfalten und neben einer Beeinträchtigung der Spermatogenese oder Spermienfunktion auch Hormon- und Sexualstörungen verursachen. Aufgrund der komplexen Regulation des männlichen Reproduktionssystems sowie der begrenzten Übertragbarkeit tierexperimenteller Befunde und In-vitro-Daten auf die Situation beim Menschen liegen allerdings nur für wenige Noxen gesicherte Erkenntnisse vor. In der andrologischen Sprechstunde sollten bei Erhebung der Anamnese potenzielle Expositionsrisiken erfasst und die Patienten über eine gesicherte oder mögliche Relevanz für ihre Fertilität aufgeklärt werden.
Literatur
4.
Zurück zum Zitat Alvarez S (2015) Do some addictions interfere with fertility? Fertil Steril 103(1):22–26PubMedCrossRef Alvarez S (2015) Do some addictions interfere with fertility? Fertil Steril 103(1):22–26PubMedCrossRef
5.
Zurück zum Zitat Andersen E, Juhl CR, Kjøller ET, Lundgren JR, Janus C, Dehestani Y, Saupstad M, Ingerslev LR, Duun OM, Jensen SBK, Holst JJ, Stallknecht BM, Madsbad S, Torekov SS, Barrès R (2022) Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP‑1 analogue treatment: a randomized controlled trial. Hum Reprod 37(7):1414–1422. https://doi.org/10.1093/humrep/deac096CrossRefPubMedPubMedCentral Andersen E, Juhl CR, Kjøller ET, Lundgren JR, Janus C, Dehestani Y, Saupstad M, Ingerslev LR, Duun OM, Jensen SBK, Holst JJ, Stallknecht BM, Madsbad S, Torekov SS, Barrès R (2022) Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP‑1 analogue treatment: a randomized controlled trial. Hum Reprod 37(7):1414–1422. https://​doi.​org/​10.​1093/​humrep/​deac096CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Bonde JP (2006) Effects of lifestyle and toxicants. In: Schill W‑B, Comhaire F, Hargreave TB (Hrsg) Andrology for the clinician. Springer, Heidelberg, S 348–357CrossRef Bonde JP (2006) Effects of lifestyle and toxicants. In: Schill W‑B, Comhaire F, Hargreave TB (Hrsg) Andrology for the clinician. Springer, Heidelberg, S 348–357CrossRef
8.
Zurück zum Zitat Bonde JP, Flachs EM, Rimborg S, Glazer CH, Giwercman A, Ramlau-Hansen CH, Hougaard KS, Høyer BB, Hærvig KK, Petersen SB, Rylander L, Specht IO, Toft G, Bräuner EV (2016) The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis. Hum Reprod Update 23(1):104–125PubMedPubMedCentralCrossRef Bonde JP, Flachs EM, Rimborg S, Glazer CH, Giwercman A, Ramlau-Hansen CH, Hougaard KS, Høyer BB, Hærvig KK, Petersen SB, Rylander L, Specht IO, Toft G, Bräuner EV (2016) The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis. Hum Reprod Update 23(1):104–125PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Brenker C, Rehfeld A, Schiffer C, Kierzek M, Kaupp UB, Skakkebæk NE, Strünker T (2018) Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals. Hum Reprod 33(10):1915–1923PubMedCrossRef Brenker C, Rehfeld A, Schiffer C, Kierzek M, Kaupp UB, Skakkebæk NE, Strünker T (2018) Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals. Hum Reprod 33(10):1915–1923PubMedCrossRef
10.
Zurück zum Zitat Broe A, Pottegård A, Hallas J, Ahern TP, Fedder J, Damkier P (2018) Association between use of phthalate-containing medication and semen quality among men in couples referred for assisted reproduction. Hum Reprod 33(3):503–511PubMedPubMedCentralCrossRef Broe A, Pottegård A, Hallas J, Ahern TP, Fedder J, Damkier P (2018) Association between use of phthalate-containing medication and semen quality among men in couples referred for assisted reproduction. Hum Reprod 33(3):503–511PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Carroll K, Pottinger AM, Wynter S, DaCosta V (2020) Marijuana use and its influence on sperm morphology and motility: identified risk for fertility among Jamaican men. Andrology 8(1):136–142PubMedCrossRef Carroll K, Pottinger AM, Wynter S, DaCosta V (2020) Marijuana use and its influence on sperm morphology and motility: identified risk for fertility among Jamaican men. Andrology 8(1):136–142PubMedCrossRef
13.
Zurück zum Zitat Chastain LG, Sarkar DK (2017) Alcohol effects on the epigenome in the germline: role in the inheritance of alcohol-related pathology. Alcohol 60:53–66PubMedPubMedCentralCrossRef Chastain LG, Sarkar DK (2017) Alcohol effects on the epigenome in the germline: role in the inheritance of alcohol-related pathology. Alcohol 60:53–66PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Choy CM, Lam CW, Cheung LT, Briton-Jones CM, Cheung LP, Haines CJ (2002) Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. BJOG 109(10):1121–1125PubMed Choy CM, Lam CW, Cheung LT, Briton-Jones CM, Cheung LP, Haines CJ (2002) Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. BJOG 109(10):1121–1125PubMed
15.
Zurück zum Zitat Corona G, Sansone A, Pallotti F, Ferlin A, Pivonello R, Isidori AM, Maggi M, Jannini EA (2020) People smoke for nicotine, but lose sexual and reproductive health for tar: a narrative review on the effect of cigarette smoking on male sexuality and reproduction. J Endocrinol Invest 43(10):1391–1408PubMedCrossRef Corona G, Sansone A, Pallotti F, Ferlin A, Pivonello R, Isidori AM, Maggi M, Jannini EA (2020) People smoke for nicotine, but lose sexual and reproductive health for tar: a narrative review on the effect of cigarette smoking on male sexuality and reproduction. J Endocrinol Invest 43(10):1391–1408PubMedCrossRef
17.
Zurück zum Zitat De-Celis R, Feria-Velasco A, Gonzalez-Unzaga M, Torres-Calleja J, Pedron-Nuevo N (2000) Semen quality of workers occupationally exposed to hydrocarbons. Fertil Steril 73:221–228PubMedCrossRef De-Celis R, Feria-Velasco A, Gonzalez-Unzaga M, Torres-Calleja J, Pedron-Nuevo N (2000) Semen quality of workers occupationally exposed to hydrocarbons. Fertil Steril 73:221–228PubMedCrossRef
19.
Zurück zum Zitat El-Shahawy O, Shah T, Obisesan OH, Durr M, Stokes AC, Uddin I, Pinjani R, Benjamin EJ, Mirbolouk M, Osei AD, Loney T, Sherman SE, Blaha MJ (2022) Association of E‑cigarettes with erectile dysfunction: the population assessment of tobacco and health study. Am J Prev Med 62(1):26–38. https://doi.org/10.1016/j.amepre.2021.08.004CrossRefPubMed El-Shahawy O, Shah T, Obisesan OH, Durr M, Stokes AC, Uddin I, Pinjani R, Benjamin EJ, Mirbolouk M, Osei AD, Loney T, Sherman SE, Blaha MJ (2022) Association of E‑cigarettes with erectile dysfunction: the population assessment of tobacco and health study. Am J Prev Med 62(1):26–38. https://​doi.​org/​10.​1016/​j.​amepre.​2021.​08.​004CrossRefPubMed
20.
Zurück zum Zitat Fronczak CM, Kim ED, Barqawi AB (2012) The insults of illicit drug use on male fertility. J Androl 33(4):515–528PubMedCrossRef Fronczak CM, Kim ED, Barqawi AB (2012) The insults of illicit drug use on male fertility. J Androl 33(4):515–528PubMedCrossRef
21.
Zurück zum Zitat Garolla A, Torino M, Sartini B, Cosci I, Patassini C, Carraro U, Foresta C (2013) Seminal and molecular evidence that sauna exposure affects human spermatogenesis. Hum Reprod 28:877–885PubMedCrossRef Garolla A, Torino M, Sartini B, Cosci I, Patassini C, Carraro U, Foresta C (2013) Seminal and molecular evidence that sauna exposure affects human spermatogenesis. Hum Reprod 28:877–885PubMedCrossRef
22.
Zurück zum Zitat Gaskins AJ, Colaci DS, Mendiola J, Swan SH, Chavarro JE (2012) Dietary patterns and semen quality in young men. Hum Reprod 27(10):2899–2907PubMedPubMedCentralCrossRef Gaskins AJ, Colaci DS, Mendiola J, Swan SH, Chavarro JE (2012) Dietary patterns and semen quality in young men. Hum Reprod 27(10):2899–2907PubMedPubMedCentralCrossRef
23.
Zurück zum Zitat Gaskins AJ, Mendiola J, Afeiche M, Jørgensen N, Swan SH, Chavarro JE (2015) Physical activity and television watching in relation to semen quality in young men. Br J Sports Med 49:265–270PubMedCrossRef Gaskins AJ, Mendiola J, Afeiche M, Jørgensen N, Swan SH, Chavarro JE (2015) Physical activity and television watching in relation to semen quality in young men. Br J Sports Med 49:265–270PubMedCrossRef
25.
Zurück zum Zitat Gianfrilli D, Ferlin A, Isidori AM, Garolla A, Maggi M, Pivonello R, Santi D, Sansone A, Balercia G, Granata ARM, Sinisi A, Lanfranco F, Pasqualetti P, Foresta C, Lenzi A (2019) Risk behaviours and alcohol in adolescence are negatively associated with testicular volume: results from the amico-andrologo survey. Andrology 7(6):769–777PubMedCrossRef Gianfrilli D, Ferlin A, Isidori AM, Garolla A, Maggi M, Pivonello R, Santi D, Sansone A, Balercia G, Granata ARM, Sinisi A, Lanfranco F, Pasqualetti P, Foresta C, Lenzi A (2019) Risk behaviours and alcohol in adolescence are negatively associated with testicular volume: results from the amico-andrologo survey. Andrology 7(6):769–777PubMedCrossRef
27.
Zurück zum Zitat Gundersen TD, Jørgensen N, Andersson AM, Bang AK, Nordkap L, Skakkebæk NE, Priskorn L, Juul A, Jensen TK (2015) Association between use of marijuana and male reproductive hormones and semen quality: a study among 1,215 healthy young men. Am J Epidemiol 182:473–481PubMedCrossRef Gundersen TD, Jørgensen N, Andersson AM, Bang AK, Nordkap L, Skakkebæk NE, Priskorn L, Juul A, Jensen TK (2015) Association between use of marijuana and male reproductive hormones and semen quality: a study among 1,215 healthy young men. Am J Epidemiol 182:473–481PubMedCrossRef
29.
Zurück zum Zitat Hales BF, Robaire B (2020) Effects of brominated and organophosphate ester flame retardants on male reproduction. Andrology 8(4):915–923PubMedCrossRef Hales BF, Robaire B (2020) Effects of brominated and organophosphate ester flame retardants on male reproduction. Andrology 8(4):915–923PubMedCrossRef
31.
Zurück zum Zitat Hassan MAM, Killick SR (2004) Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril 81:384–392PubMedCrossRef Hassan MAM, Killick SR (2004) Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril 81:384–392PubMedCrossRef
32.
Zurück zum Zitat Hipwell AE, Kahn LG, Factor-Litvak P, Porucznik CA, Siegel EL, Fichorova RN, Hamman RF, Klein-Fedyshin M, Harley KG (2019) Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review. Hum Reprod Update 25(1):51–71PubMedCrossRef Hipwell AE, Kahn LG, Factor-Litvak P, Porucznik CA, Siegel EL, Fichorova RN, Hamman RF, Klein-Fedyshin M, Harley KG (2019) Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review. Hum Reprod Update 25(1):51–71PubMedCrossRef
33.
Zurück zum Zitat Holmboe SA, Priskorn L, Jensen TK, Skakkebaek NE, Andersson AM, Jørgensen N (2020) Use of e‑cigarettes associated with lower sperm counts in a cross-sectional study of young men from the general population. Hum Reprod 35(7):1693–1701PubMedCrossRef Holmboe SA, Priskorn L, Jensen TK, Skakkebaek NE, Andersson AM, Jørgensen N (2020) Use of e‑cigarettes associated with lower sperm counts in a cross-sectional study of young men from the general population. Hum Reprod 35(7):1693–1701PubMedCrossRef
34.
Zurück zum Zitat Høyer S, Riis AH, Toft G, Wise LA, Hatch EE, Wesselink AK, Rothman KJ, Sørensen HT, Mikkelsen EM (2020) Male alcohol consumption and fecundability. Hum Reprod 35(4):816–825PubMedPubMedCentralCrossRef Høyer S, Riis AH, Toft G, Wise LA, Hatch EE, Wesselink AK, Rothman KJ, Sørensen HT, Mikkelsen EM (2020) Male alcohol consumption and fecundability. Hum Reprod 35(4):816–825PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Jensen T, Gottschau M, Broby Madsen J, Andersson AM, Harmer T, Skakkebæk N et al (2014) Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1221 young Danish men. BMJ Open 4:e5462PubMedPubMedCentralCrossRef Jensen T, Gottschau M, Broby Madsen J, Andersson AM, Harmer T, Skakkebæk N et al (2014) Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1221 young Danish men. BMJ Open 4:e5462PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Jordan T, Ngo B, Jones C (2020) The use of cannabis and perceptions of its effect on fertility among infertility patients. Hum Reprod Open 2020(1):hoz41PubMedPubMedCentralCrossRef Jordan T, Ngo B, Jones C (2020) The use of cannabis and perceptions of its effect on fertility among infertility patients. Hum Reprod Open 2020(1):hoz41PubMedPubMedCentralCrossRef
37.
Zurück zum Zitat Jung A, Schuppe HC (2007) Influence of genital heat stress on semen quality in humans. Andrologia 39:203–215PubMedCrossRef Jung A, Schuppe HC (2007) Influence of genital heat stress on semen quality in humans. Andrologia 39:203–215PubMedCrossRef
38.
Zurück zum Zitat Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L (2020) Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol 8:703–718PubMedPubMedCentralCrossRef Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L (2020) Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol 8:703–718PubMedPubMedCentralCrossRef
39.
Zurück zum Zitat Karayiannis D, Kontogianni MD, Mendorou C, Douka L, Mastrominas M, Yiannakouris N (2017) Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Hum Reprod 32(1):215–222PubMed Karayiannis D, Kontogianni MD, Mendorou C, Douka L, Mastrominas M, Yiannakouris N (2017) Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Hum Reprod 32(1):215–222PubMed
40.
Zurück zum Zitat Karmon AE, Toth TL, Chiu YH, Gaskins AJ, Tanrikut C, Wright DL, Hauser R, Chavarro JE (2017) Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients. Andrology 5(2):354–361PubMedPubMedCentralCrossRef Karmon AE, Toth TL, Chiu YH, Gaskins AJ, Tanrikut C, Wright DL, Hauser R, Chavarro JE (2017) Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients. Andrology 5(2):354–361PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Kiguradze T, Temps WH, Yarnold PR, Cashy J, Brannigan RE, Nardone B, Micali G, West DP, Belknap SM (2017) Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride. PeerJ 5:e3020PubMedPubMedCentralCrossRef Kiguradze T, Temps WH, Yarnold PR, Cashy J, Brannigan RE, Nardone B, Micali G, West DP, Belknap SM (2017) Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride. PeerJ 5:e3020PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Köhn F‑M, Schuppe H‑C (2016) Umweltfaktoren und männliche Fertilität. Urologe A 55:877–882PubMedCrossRef Köhn F‑M, Schuppe H‑C (2016) Umweltfaktoren und männliche Fertilität. Urologe A 55:877–882PubMedCrossRef
46.
Zurück zum Zitat Lerchl A (2013) Electromagnetic pollution: another risk factor for infertility, or a red herring? Asian J Androl 15:201–203PubMedCrossRef Lerchl A (2013) Electromagnetic pollution: another risk factor for infertility, or a red herring? Asian J Androl 15:201–203PubMedCrossRef
47.
Zurück zum Zitat Levine RJ, Brown MH, Bell M, Shue F, Greenberg GN, Bordson BL (1992) Air-conditioned environments do not prevent deterioration of human semen quality during the summer. Fertil Steril 57:1075–1083PubMedCrossRef Levine RJ, Brown MH, Bell M, Shue F, Greenberg GN, Bordson BL (1992) Air-conditioned environments do not prevent deterioration of human semen quality during the summer. Fertil Steril 57:1075–1083PubMedCrossRef
48.
Zurück zum Zitat Liu K, Li Y, Zhang G, Liu J, Cao J, Ao L, Zhang S (2014) Association between mobile phone use and semen quality: a systemic review and meta-analysis. Andrology 2:491–501PubMedCrossRef Liu K, Li Y, Zhang G, Liu J, Cao J, Ao L, Zhang S (2014) Association between mobile phone use and semen quality: a systemic review and meta-analysis. Andrology 2:491–501PubMedCrossRef
49.
Zurück zum Zitat Liu K, Hou G, Wang X, Chen H, Shi F, Liu C, Zhang X, Han F, Yang H, Zhou N, Ao L, Liu J, Cao J, Chen Q (2020) Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study. Hum Reprod 35(7):1515–1528PubMedPubMedCentralCrossRef Liu K, Hou G, Wang X, Chen H, Shi F, Liu C, Zhang X, Han F, Yang H, Zhou N, Ao L, Liu J, Cao J, Chen Q (2020) Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study. Hum Reprod 35(7):1515–1528PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat McBride JA, Coward RM (2016) Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use. Asian J Androl 18(3):373–380PubMedPubMedCentralCrossRef McBride JA, Coward RM (2016) Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use. Asian J Androl 18(3):373–380PubMedPubMedCentralCrossRef
53.
Zurück zum Zitat Mínguez-Alarcón L, Chavarro JE, Mendiola J, Gaskins AJ, Torres-Cantero AM (2014) Physical activity is not related to semen quality in young healthy men. Fertil Steril 102:1103–1109PubMedPubMedCentralCrossRef Mínguez-Alarcón L, Chavarro JE, Mendiola J, Gaskins AJ, Torres-Cantero AM (2014) Physical activity is not related to semen quality in young healthy men. Fertil Steril 102:1103–1109PubMedPubMedCentralCrossRef
54.
Zurück zum Zitat Mínguez-Alarcón L, Gaskins AJ, Chiu YH, Messerlian C, Williams PL, Ford JB, Souter I, Hauser R, Chavarro JE (2018) Type of underwear worn and markers of testicular function among men attending a fertility center. Hum Reprod 33(9):1749–1756PubMedPubMedCentralCrossRef Mínguez-Alarcón L, Gaskins AJ, Chiu YH, Messerlian C, Williams PL, Ford JB, Souter I, Hauser R, Chavarro JE (2018) Type of underwear worn and markers of testicular function among men attending a fertility center. Hum Reprod 33(9):1749–1756PubMedPubMedCentralCrossRef
55.
Zurück zum Zitat Mínguez-Alarcón L, Bellavia A, Gaskins AJ, Chavarro JE, Ford JB, Souter I, Calafat AM, Hauser R, Williams PL, Study Team EARTH (2021) Paternal mixtures of urinary concentrations of phthalate metabolites, bisphenol A and parabens in relation to pregnancy outcomes among couples attending a fertility center. Environ Int 146:106171. https://doi.org/10.1016/j.envint.2020.106171CrossRefPubMed Mínguez-Alarcón L, Bellavia A, Gaskins AJ, Chavarro JE, Ford JB, Souter I, Calafat AM, Hauser R, Williams PL, Study Team EARTH (2021) Paternal mixtures of urinary concentrations of phthalate metabolites, bisphenol A and parabens in relation to pregnancy outcomes among couples attending a fertility center. Environ Int 146:106171. https://​doi.​org/​10.​1016/​j.​envint.​2020.​106171CrossRefPubMed
56.
Zurück zum Zitat Møllerløkken OJ, Moen BE (2008) Is fertility reduced among men exposed to radiofrequency fields in the Norwegian navy? Bioelectromagnetics 29:345–352PubMedCrossRef Møllerløkken OJ, Moen BE (2008) Is fertility reduced among men exposed to radiofrequency fields in the Norwegian navy? Bioelectromagnetics 29:345–352PubMedCrossRef
58.
Zurück zum Zitat Nassan FL, Arvizu M, Mínguez-Alarcón L, Williams PL, Attaman J, Petrozza J, Hauser R, Chavarro J (2019) Marijuana smoking and markers of testicular function among men from a fertility centre. Hum Reprod 34(4):715–723PubMedPubMedCentralCrossRef Nassan FL, Arvizu M, Mínguez-Alarcón L, Williams PL, Attaman J, Petrozza J, Hauser R, Chavarro J (2019) Marijuana smoking and markers of testicular function among men from a fertility centre. Hum Reprod 34(4):715–723PubMedPubMedCentralCrossRef
59.
Zurück zum Zitat Nazmara Z, Najafi M, Rezaei-Mojaz S, Movahedin M, Zandiyeh Z, Shirinbayan P, Roshanpajouh M, Asgari HR, Hosseini Jafari Lavasani L, Koruji M (2019) The effect of heroin addiction on human sperm parameters, histone-to-protamine transition, and serum sexual hormones levels. Urol J 16(3):289–294PubMed Nazmara Z, Najafi M, Rezaei-Mojaz S, Movahedin M, Zandiyeh Z, Shirinbayan P, Roshanpajouh M, Asgari HR, Hosseini Jafari Lavasani L, Koruji M (2019) The effect of heroin addiction on human sperm parameters, histone-to-protamine transition, and serum sexual hormones levels. Urol J 16(3):289–294PubMed
61.
Zurück zum Zitat Nieschlag E, Vorona E (2015) Mechanisms in endocrinology: medical consequences of doping with anabolic androgenic steroids: effects on reproductive functions. Eur J Endocrinol 173:R47–R58PubMedCrossRef Nieschlag E, Vorona E (2015) Mechanisms in endocrinology: medical consequences of doping with anabolic androgenic steroids: effects on reproductive functions. Eur J Endocrinol 173:R47–R58PubMedCrossRef
62.
Zurück zum Zitat Nordkap L, Jensen TK, Hansen ÅM, Lassen TH, Bang AK, Joensen UN, Blomberg Jensen M, Skakkebæk NE, Jørgensen N (2016) Psychological stress and testicular function: a cross-sectional study of 1,215 Danish men. Fertil Steril 105(1):174–187PubMedCrossRef Nordkap L, Jensen TK, Hansen ÅM, Lassen TH, Bang AK, Joensen UN, Blomberg Jensen M, Skakkebæk NE, Jørgensen N (2016) Psychological stress and testicular function: a cross-sectional study of 1,215 Danish men. Fertil Steril 105(1):174–187PubMedCrossRef
63.
Zurück zum Zitat Nordkap L, Priskorn L, Bräuner EV, Hansen MÅ, Kirstine Bang A, Holmboe SA, Winge SB, Egeberg Palme DL, Mørup N, Skakkebaek EN, Kold Jensen T, Jørgensen N (2020) Impact of psychological stress measured in three different scales on testis function: a cross-sectional study of 1362 young men. Andrology. https://doi.org/10.1111/andr.12835CrossRefPubMed Nordkap L, Priskorn L, Bräuner EV, Hansen MÅ, Kirstine Bang A, Holmboe SA, Winge SB, Egeberg Palme DL, Mørup N, Skakkebaek EN, Kold Jensen T, Jørgensen N (2020) Impact of psychological stress measured in three different scales on testis function: a cross-sectional study of 1362 young men. Andrology. https://​doi.​org/​10.​1111/​andr.​12835CrossRefPubMed
65.
Zurück zum Zitat Pflieger-Bruss S, Schuppe H‑C, Schill W‑B (2004) The male reproductive system and its susceptibility to endocrine disrupting chemicals. Andrologia 36:337–345PubMedCrossRef Pflieger-Bruss S, Schuppe H‑C, Schill W‑B (2004) The male reproductive system and its susceptibility to endocrine disrupting chemicals. Andrologia 36:337–345PubMedCrossRef
66.
Zurück zum Zitat Potashnik G, Porath A (1995) Dibromochloropropane (DBCP): a 17-year reassessment of testicular function and reproductive performance. J Occup Environ Med 37:1278–1291CrossRef Potashnik G, Porath A (1995) Dibromochloropropane (DBCP): a 17-year reassessment of testicular function and reproductive performance. J Occup Environ Med 37:1278–1291CrossRef
68.
Zurück zum Zitat Rajanahally S, Raheem O, Rogers M, Brisbane W, Ostrowski K, Lendvay T, Walsh T (2019) The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review. Andrology 7(2):139–147PubMedCrossRef Rajanahally S, Raheem O, Rogers M, Brisbane W, Ostrowski K, Lendvay T, Walsh T (2019) The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review. Andrology 7(2):139–147PubMedCrossRef
69.
Zurück zum Zitat Rao M et al (2015) Effect of transient scrotal hyperthermia on sperm parameters, seminal plasma biochemical markers, and oxidative stress in men. Asian J Androl 17:668–675PubMedPubMedCentralCrossRef Rao M et al (2015) Effect of transient scrotal hyperthermia on sperm parameters, seminal plasma biochemical markers, and oxidative stress in men. Asian J Androl 17:668–675PubMedPubMedCentralCrossRef
71.
Zurück zum Zitat Rehfeld A et al (2022) Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism. Hum Reprod 37(5):922–935PubMedCrossRef Rehfeld A et al (2022) Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism. Hum Reprod 37(5):922–935PubMedCrossRef
72.
Zurück zum Zitat Ricci E, Al Beitawi S, Cipriani S, Candiani M, Chiaffarino F, Viganò P, Noli S, Parazzini F (2017) Semen quality and alcohol intake: a systematic review and meta-analysis. Reprod Biomed Online 34:38–47PubMedCrossRef Ricci E, Al Beitawi S, Cipriani S, Candiani M, Chiaffarino F, Viganò P, Noli S, Parazzini F (2017) Semen quality and alcohol intake: a systematic review and meta-analysis. Reprod Biomed Online 34:38–47PubMedCrossRef
73.
Zurück zum Zitat Ricci E, Viganò P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, Parazzini F (2017) Coffee and caffeine intake and male infertility: a systematic review. Nutr J 16:37PubMedPubMedCentralCrossRef Ricci E, Viganò P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, Parazzini F (2017) Coffee and caffeine intake and male infertility: a systematic review. Nutr J 16:37PubMedPubMedCentralCrossRef
74.
Zurück zum Zitat Rosety MÁ, Díaz AJ, Rosety JM, Pery MT, Brenes-Martín F, Bernardi M, García N, Rosety-Rodríguez M, Ordoñez FJ, Rosety I (2017) Exercise improved semen quality and reproductive hormone levels in sedentary obese adults. Nutr Hosp 34:603–607PubMedCrossRef Rosety MÁ, Díaz AJ, Rosety JM, Pery MT, Brenes-Martín F, Bernardi M, García N, Rosety-Rodríguez M, Ordoñez FJ, Rosety I (2017) Exercise improved semen quality and reproductive hormone levels in sedentary obese adults. Nutr Hosp 34:603–607PubMedCrossRef
75.
Zurück zum Zitat Rowley MJ, Leach DR, Warner GA, Heller CG (1974) Effect of graded doses of ionizing radiation on the human testis. Radiat Res 59:665–678PubMedCrossRef Rowley MJ, Leach DR, Warner GA, Heller CG (1974) Effect of graded doses of ionizing radiation on the human testis. Radiat Res 59:665–678PubMedCrossRef
76.
Zurück zum Zitat Salas-Huetos A, Bulló M, Salas-Salvadó J (2017) Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update 23:371–389PubMedCrossRef Salas-Huetos A, Bulló M, Salas-Salvadó J (2017) Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update 23:371–389PubMedCrossRef
77.
Zurück zum Zitat Samavat J, Cantini G, Lotti F, Di Franco A, Tamburrino L, Degl’Innocenti S, Maseroli E, Filimberti E, Facchiano E, Lucchese M, Muratori M, Forti G, Baldi E, Maggi M, Luconi M (2017) Massive weight loss obtained by bariatric surgery affects semen quality in morbid male obesity: a preliminary prospective double-armed study. Obes Surg. https://doi.org/10.1007/s11695-017-2802-7CrossRef Samavat J, Cantini G, Lotti F, Di Franco A, Tamburrino L, Degl’Innocenti S, Maseroli E, Filimberti E, Facchiano E, Lucchese M, Muratori M, Forti G, Baldi E, Maggi M, Luconi M (2017) Massive weight loss obtained by bariatric surgery affects semen quality in morbid male obesity: a preliminary prospective double-armed study. Obes Surg. https://​doi.​org/​10.​1007/​s11695-017-2802-7CrossRef
78.
Zurück zum Zitat Samplaski MK, Lo K, Grober E, Jarvi K (2013) Finasteride use in the male infertility population: effects on semen and hormone parameters. Fertil Steril 100(6):1542–1546PubMedCrossRef Samplaski MK, Lo K, Grober E, Jarvi K (2013) Finasteride use in the male infertility population: effects on semen and hormone parameters. Fertil Steril 100(6):1542–1546PubMedCrossRef
79.
Zurück zum Zitat Schagdarsurengin U, Steger K (2016) Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health. Nat Rev Urol 13:584–595PubMedCrossRef Schagdarsurengin U, Steger K (2016) Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health. Nat Rev Urol 13:584–595PubMedCrossRef
80.
Zurück zum Zitat Schuppe H‑C, Jung A, Köhn F‑M, Haidl G (2011) Wie Genußgifte die Fertilität beeinflussen können. MMW Fortschr Med 153(6):33–36PubMedCrossRef Schuppe H‑C, Jung A, Köhn F‑M, Haidl G (2011) Wie Genußgifte die Fertilität beeinflussen können. MMW Fortschr Med 153(6):33–36PubMedCrossRef
81.
Zurück zum Zitat Schuppe H‑C, Köhn F‑M (2018) Andrologie. In: Plewig G et al (Hrsg) Braun-Falco’s Dermatologie, Venerologie und Allergologie, 7. Aufl. Springer, Berlin, Heidelberg Schuppe H‑C, Köhn F‑M (2018) Andrologie. In: Plewig G et al (Hrsg) Braun-Falco’s Dermatologie, Venerologie und Allergologie, 7. Aufl. Springer, Berlin, Heidelberg
82.
Zurück zum Zitat Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, Perrin J (2017) The impact of drugs on male fertility: a review. Andrology 5(4):640–663PubMedCrossRef Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, Perrin J (2017) The impact of drugs on male fertility: a review. Andrology 5(4):640–663PubMedCrossRef
83.
Zurück zum Zitat Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt JM, Ramlau-Hansen CH, Borges E Jr, Lotti F, Steegers-Theunissen RP, Zorn B, Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Lévy R, Czernichow S (2013) BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update 19:221–231PubMedCrossRef Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt JM, Ramlau-Hansen CH, Borges E Jr, Lotti F, Steegers-Theunissen RP, Zorn B, Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Lévy R, Czernichow S (2013) BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update 19:221–231PubMedCrossRef
84.
Zurück zum Zitat Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, Toppari J, Andersson AM, Eisenberg ML, Jensen TK, Jørgensen N, Swan SH, Sapra KJ, Ziebe S, Priskorn L, Juul A (2016) Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev 96(1):55–97PubMedCrossRef Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, Toppari J, Andersson AM, Eisenberg ML, Jensen TK, Jørgensen N, Swan SH, Sapra KJ, Ziebe S, Priskorn L, Juul A (2016) Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev 96(1):55–97PubMedCrossRef
85.
Zurück zum Zitat Skarberg K, Nyberg F, Engstrom I (2009) Multisubstance use as a feature of addiction to anabolic-androgenic steroids. Eur Addict Res 15(2):99–106PubMedCrossRef Skarberg K, Nyberg F, Engstrom I (2009) Multisubstance use as a feature of addiction to anabolic-androgenic steroids. Eur Addict Res 15(2):99–106PubMedCrossRef
86.
Zurück zum Zitat Somers CM (2011) Ambient air pollution exposure and damage to male gametes: Human studies and in situ „sentinel“ animal experiments. Syst Biol Reprod Med 57:63–71PubMedCrossRef Somers CM (2011) Ambient air pollution exposure and damage to male gametes: Human studies and in situ „sentinel“ animal experiments. Syst Biol Reprod Med 57:63–71PubMedCrossRef
87.
Zurück zum Zitat Sun B, Messerlian C, Sun ZH, Duan P, Chen HG, Chen YJ, Wang P, Wang L, Meng TQ, Wang Q, Arvizu M, Chavarro JE, Wang YX, Xiong CL, Pan A (2019) Physical activity and sedentary time in relation to semen quality in healthy men screened as potential sperm donors. Hum Reprod 34(12):2330–2339PubMedCrossRef Sun B, Messerlian C, Sun ZH, Duan P, Chen HG, Chen YJ, Wang P, Wang L, Meng TQ, Wang Q, Arvizu M, Chavarro JE, Wang YX, Xiong CL, Pan A (2019) Physical activity and sedentary time in relation to semen quality in healthy men screened as potential sperm donors. Hum Reprod 34(12):2330–2339PubMedCrossRef
88.
Zurück zum Zitat Suri S, Dehghan SF, Sahlabadi AS, Ardakani SK, Moradi N, Rahmati M, Tehrani FR (2020) Relationship between exposure to Extremely Low-Frequency (ELF) magnetic field and the level of some reproductive hormones among power plant workers. J Occup Health 62:e12173PubMedPubMedCentralCrossRef Suri S, Dehghan SF, Sahlabadi AS, Ardakani SK, Moradi N, Rahmati M, Tehrani FR (2020) Relationship between exposure to Extremely Low-Frequency (ELF) magnetic field and the level of some reproductive hormones among power plant workers. J Occup Health 62:e12173PubMedPubMedCentralCrossRef
89.
Zurück zum Zitat Tas S, Lauwerys R, Lison D (1996) Occupational hazards for the male reproductive system. Crit Rev Toxicol 26:261–307PubMedCrossRef Tas S, Lauwerys R, Lison D (1996) Occupational hazards for the male reproductive system. Crit Rev Toxicol 26:261–307PubMedCrossRef
90.
Zurück zum Zitat Tavares RS, Mansell S, Barratt CL, Wilson SM, Publicover SJ, Ramalho-Santos J (2013) p,p’-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations. Hum Reprod 28(12):3167–3177PubMedPubMedCentralCrossRef Tavares RS, Mansell S, Barratt CL, Wilson SM, Publicover SJ, Ramalho-Santos J (2013) p,p’-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations. Hum Reprod 28(12):3167–3177PubMedPubMedCentralCrossRef
94.
Zurück zum Zitat Veulemans H, Steeno O, Masschelein R, Groeseneken D (1993) Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study. Br J Ind Med 50:71–78PubMedPubMedCentral Veulemans H, Steeno O, Masschelein R, Groeseneken D (1993) Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study. Br J Ind Med 50:71–78PubMedPubMedCentral
95.
Zurück zum Zitat Vine MF, Margolin BH, Morrison HI, Hulka BS (1994) Cigarette smoking and sperm density: a meta-analysis. Fertil Steril 61:35–43PubMedCrossRef Vine MF, Margolin BH, Morrison HI, Hulka BS (1994) Cigarette smoking and sperm density: a meta-analysis. Fertil Steril 61:35–43PubMedCrossRef
96.
Zurück zum Zitat Wagner U, Schlebusch H, van der Ven H, van der Ven K, Diedrich K, Krebs D (1990) Accumulation of pollutants in the genital tract of sterility patients. J Clin Chem Clin Biochem 28:683–688PubMed Wagner U, Schlebusch H, van der Ven H, van der Ven K, Diedrich K, Krebs D (1990) Accumulation of pollutants in the genital tract of sterility patients. J Clin Chem Clin Biochem 28:683–688PubMed
97.
Zurück zum Zitat Woodruff TJ, Carlson A, Schwartz JM, Giudice LC (2008) Proceedings of the summit on environmental challenges to reproductive health and fertility: executive summary. Fertil Steril 89(2):281–300PubMedPubMedCentralCrossRef Woodruff TJ, Carlson A, Schwartz JM, Giudice LC (2008) Proceedings of the summit on environmental challenges to reproductive health and fertility: executive summary. Fertil Steril 89(2):281–300PubMedPubMedCentralCrossRef
98.
Zurück zum Zitat World Health Organization (2021) WHO laboratory manual for the examination and processing of human semen, 6. Aufl. WHO Press, Geneva World Health Organization (2021) WHO laboratory manual for the examination and processing of human semen, 6. Aufl. WHO Press, Geneva
100.
Zurück zum Zitat Zitzmann M et al (2003) Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 79:1550–1554PubMedCrossRef Zitzmann M et al (2003) Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 79:1550–1554PubMedCrossRef
Metadaten
Titel
Umweltfaktoren, Lebensstil und männliche Fertilität
verfasst von
Prof. Dr. med. Hans-Christian Schuppe
Prof. Dr. med. Frank-Michael Köhn
Publikationsdatum
12.10.2022
Verlag
Springer Medizin
Erschienen in
Die Urologie / Ausgabe 11/2022
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI
https://doi.org/10.1007/s00120-022-01951-z

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