Erschienen in:
13.05.2019 | Original Article
Upper reference limits of transient ischemic dilation ratio for different protocols on new-generation cadmium zinc telluride cameras: A report from REFINE SPECT registry
verfasst von:
Lien-Hsin Hu, MD, Tali Sharir, MD, Robert J. H. Miller, MD, Andrew J. Einstein, MD, PhD, Mathews B. Fish, MD, Terrence D. Ruddy, MD, Sharmila Dorbala, MD, Marcelo Di Carli, MD, Philipp A. Kaufmann, MD, Albert J. Sinusas, MD, Edward J. Miller, MD, PhD, Timothy M. Bateman, MD, Julian Betancur, PhD, Guido Germano, PhD, Joanna X. Liang, BA, Frederic Commandeur, PhD, Peyman N. Azadani, MD, Heidi Gransar, MS, Yuka Otaki, MD, Balaji K. Tamarappoo, MD, Damini Dey, PhD, Daniel S. Berman, MD, Piotr J. Slomka, PhD
Erschienen in:
Journal of Nuclear Cardiology
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Ausgabe 4/2020
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Abstract
Background
Upper reference limits for transient ischemic dilation (TID) have not been rigorously established for cadmium-zinc-telluride (CZT) camera systems. We aimed to derive TID limits for common myocardial perfusion imaging protocols utilizing a large, multicenter registry (REFINE SPECT).
Methods
One thousand six hundred and seventy-two patients with low likelihood of coronary artery disease with normal perfusion findings were identified. Images were processed with Quantitative Perfusion SPECT software (Cedars-Sinai Medical Center, Los Angeles, CA). Non-attenuation-corrected, camera-, radiotracer-, and stress protocol-specific TID limits in supine position were derived from 97.5th percentile and mean + 2 standard deviations (SD). Reference limits were compared for different solid-state cameras (D-SPECT vs. Discovery), radiotracers (technetium-99m-sestamibi vs. tetrofosmin), different types of stress (exercise vs. four different vasodilator-based protocols), and different vasodilator-based protocols.
Results
TID measurements did not follow Gaussian distribution in six out of eight subgroups. TID limits ranged from 1.18 to 1.52 (97.5th percentile) and 1.18 to 1.39 (mean + 2SD). No difference was noted between D-SPECT and Discovery cameras (P = 0.71) while differences between exercise and vasodilator-based protocols (adenosine, regadenoson, or regadenoson-walk) were noted (all P < 0.05).
Conclusions
We used a multicenter registry to establish camera-, radiotracer-, and protocol-specific upper reference limits of TID for supine position on CZT camera systems. Reference limits did not differ between D-SPECT and Discovery camera.