Background
Infections are among the most frequent childhood ailments. As a result, the use of antimicrobials (AMs) in pediatric patients is common practice [
1]. The use of these medicines is even higher in hospitalized pediatric patients. A multicenter study using data from 1278 children admitted to pediatric general medical wards in the United Kingdom, Germany, Australia, Hong Kong and Malaysia found that systemic antibacterials were the most commonly prescribed drug class, accounting for 25% of all prescriptions [
2]. Two studies analyzing the consumption of antimicrobials in Europe (32 hospitals) and the United States (51 hospitals) reported that a third of hospitalized children received at least one antimicrobial during their hospital stay [
3].
When examining AM utilization among hospitalized children, a number of variables are used for characterization apart from age and sex. Hospitalized children may present not only with infections but several comorbidities which may make treatments more difficult and modulate dose and treatment interval (ref). Ascertaining disease severity may also be challenging. A possible way to gage this is by measuring the length of stay, and/or time spent in an Intensive Care Unit (ICU). Additional variables to study are number and variety of AM use [
4].
Many treatments using AMs in children are off-label (OL). The most common reasons for this use are age, dose and indication [
5]. Drug-related problems are more frequent in this age group because it is the most underserved group in clinical trials due to ethical, technical and economic impediments, thus hampering the efficacy and safety of drug therapy [
6,
7]. The prevalence of OL use of medicines in hospitalized children of all age groups varies considerably (18.9-46%) [
5,
8]. Some hospitals have created protocols to support evidence-based OL use to improve safety. However, many of the recommendations set out in these protocols are not applied in practice [
9]. Furthermore, vulnerability associated to OL use is greater for newborns and infants.
In addition to clinical trials, it is also important to conduct drug utilization research (DUR) to determine the patterns, determinants and outcomes of the use of medicines in a real world setting [
10]. However, conducting DUR in Latin America is challenging due to the complexity of the healthcare system, limited reliable data and socioeconomic disparities affecting access to care and medicines [
11]. Additionally, studies on the utilization of medicines in children are further complicated by the scarcity of databases with pertinent longitudinal information, diverse procedures for recording medication use in patient records and a lack of standardization in patient data [
4].
Many of the most common diseases in childhood can not be cured with older AM any longer and newer substances have been introduced, leading to possible inappropriate use, which may enhance antimicrobial resistance, considered a global threat to human health. As such investigating AM utilization is crucial mainly in developing countries where AM stewardship is poor or not implemented and protocols are feeble.
The aim of this study was therefore to describe the utilization of AMs in hospitalized children in five hospitals in Brazil, and to investigate age-related OL use in these children.
Discussion
The distribution of age group and sex seemed similar across the five hospitals; however, the presence of comorbidities, history of ICU admission and length of hospital stay apparently differed among them. The most common diseases were respiratory tract infections. There were wide variations in DOT/1000PD (278–517) and LOT/1000PD (265–390). The hospital in SE used more AMs than the other hospitals. The consumption of second-generation penicillins and cephalosporins was high. The prevalence of OL use of AM was higher in patients from the hospital in RJ, infants, patients who underwent prolonged hospital stays and patients receiving multiple AMs. The most commonly used off-label medicine was azithromycin, in both oral and parenteral formulations.
Studies have reported age-related differences in the pharmacokinetics and pharmacodynamics of drugs due to changes in body composition during maturation, which can affect the effectiveness of drugs [
19]. There are also safety and efficacy issues related to unlicensed drug use in children [
20,
21]. Although studies have shown that hospital admission rates for infections are higher in male children [
22], the proportion of patients of each gender was quite similar. Furthermore, the frequency of AM use seemed similar between both sexes.
Most of the newborn and infants from our sample were admitted for respiratory tract infections (pneumonia, bronchitis or bronchiolitis) and skin infections, which is consistent with the findings of other studies with pediatric patients [
23,
24]. The prevalence of comorbidities, history of ICU admission and length of hospital stay were varied and it is possible that these factors influenced medicine use [
25]. However, these variables do not explain the intensive use of AMs in the hospitals since variables describing severity and AM use did not always present variation in the same direction.
There were differences in AM consumption between hospitals. The DOT/LOT ratios show that the use of multiple AMs was highest in hospitals in RS and RJ. Combination therapy is used to prevent the development of multidrug-resistant microorganisms in difficult-to-treat infections, promote synergistic interactions between active ingredients, provide a broader antibacterial spectrum and reduce the risk of mortality associated with empiric therapy [
26]. However, caution should be exercised when employing this practice, as a combination of AMs can lead to severe drug‒drug interactions [
27].
DOT and LOT are the most suitable measures for assessing AM consumption in pediatric patients because the defined daily dose does not provide an accurate assessment due to the small doses used in this population and the low weight of children [
28]. However, DOT and LOT do not measure AM appropriateness and provide an inaccurate assessment of AM dose in patients with kidney failure [
29]. In general, studies using DOT and LOT with pediatric patients show wide variations in values; however, the values found in the hospitals in SE, RJ and RS were similar to those in studies with critically ill children, suggesting intensive use of AMs [
24,
30,
31]. This does not appear to be explained by the clinical condition of the patients in our study, suggesting possible overuse of AMs in these hospitals.
A study by Kreitmeyr et al. [
24] in general pediatric wards in Germany reported DOT/1000PD values between 432.9 and 483.6. These values are higher than the minimum value found in the present study but show less variation. These differences may be explained by the standard of care, which varies from country to country, cultural and behavioral factors and the health care setting, including available resources, patient information, case urgency and prescriber characteristics, such as experience, level of expertise and adherence to guidelines [
32]. These factors may also account for the differences in DOT/1000PD and LOT/1000PD values among the hospitals in this study. However, the results point to large variation in AM utilization and also intense use of AM, possibly related to lack of/or faulty AM stewardship. As Table
1 shows in two of the five hospitals there were no stewardship programs. Lack of adequate monitoring may lead to improper and excessive use of AM.
The most commonly used drug classes belonged to groups J01C (penicillins), J01D (cephalosporins, monobactams and carbapenems), J01X (glycopeptides, polymyxins, imidazole and nitrofuran derivatives) and J01F (macrolides, lycosamines and streptogramins). Previous studies have also reported a high frequency of use of these classes in children hospitalized for similar infections [
33].
The hospital in RJ was the only hospital where antifungals were prescribed. These agents are usually prescribed for prophylaxis or the treatment of infections that generally affect neonates and immunocompromised patients [
34]. Inappropriate use of antifungals is associated with the development of resistance [
35]. In addition, the prevalence of OL use was highest in the hospital in RJ and lowest in the hospital in DF. It is worth highlighting that the hospital in RJ is a university hospital and provides care for children from a broader age group (0–18 years), possibly taking on patients with more severe conditions and complex care needs.
The prevalence of OL use was also high in children under two, patients who underwent prolonged hospital stays and patients receiving more than one medication. Previous studies in Brazil also found a high prevalence of OL use in patients with these characteristics [
36,
37]. Prolonged hospital stay is associated with increased use of AMs due to the risk of healthcare-associated infections(55), increasing the likelihood of OL use by age.
Various studies have shown widespread OL use of systemic AMs in both outpatient [
5,
20,
21] and hospitalized pediatric patients [
8,
37‐
39]. The most commonly used classes of AMs in this population are penicillins, cephalosporins and aminoglycosides, and various reasons for OL use have been reported (age group, dose, indication, among others).
In the present study, the most commonly used off-label AM was azithromycin in both oral and parenteral formulations. Azithromycin is one of the most widely used broad-spectrum AMs for the treatment of children, especially in patients with respiratory tract infections. Azithromycin is available in parenteral formulations and is commonly administered over long periods of time at low doses in children with chronic respiratory diseases due to its immunomodulatory effect [
40]. However, there is no evidence of the efficacy and safety of the use of its oral form in children under six months or its parenteral form in patients under 16 years [
41], which is worrying considering the findings of the present study.
This study has several limitations. First, the data collection period was not the same in all hospitals, meaning that results could have been affected by seasonal variation in the consumption of certain AMs. Seasonal consumption is influenced by factors such as disease prevalence, seasonal epidemics, human behavior patterns and environmental conditions [
42], and the study hospitals reflect diverse in-country contexts. Moreover, the results cannot be generalized because our sample was not representative. The inclusion of readmitted patients, as new patients, may burden certain results due to different severity profile of these patients. However, the units of analysis were patient medical records and prescriptions, and not individual patients. Reintroducing patients in these cases is an established procedure in DUR. Most of the studied in-patient facilities were university hospitals, in which research and teaching activities may have considerable influence on treatment strategies and may have accounted for duration and intensity of AM use, but the background of the establishments did not warrant adherence to AM protocols.
It is also important to consider the potential disadvantages of using DOT and LOT as measures of AM consumption. These measures allowed us to assess the volume of prescriptions and have some advantages over defined daily doses, since the DDD is a unit of measurement for adult populations. However, they are not able to measure the impact of the use of medicines with different spectrums of activity or the appropriateness of prescribed doses in relation to clinical protocols, among other limitations. Nevertheless these indicators have been employed in DUR for pediatric populations.
Finally, the classification of OL use was limited to age because there was insufficient information to assess AM regimen and indications, and it was not possible to estimate the probability of the occurrence of OL use using regression techniques, due to the descriptive nature of the study.
Despite its limitations, considering the overall lack of data on pediatric drug therapy in Brazil, this study provides valuable insight into the use of AM in hospitalized pediatric patients. It is crucial to acknowledge the scarcity of drug utilization studies and the lack of standardized care in Brazil. This may have implications for the rational use of AM, particularly concerning the choice of pharmacological classes and the quantities of administered medicines. These factors should be taken into account when evaluating the appropriate use of AM for these patients, as well as for pediatric patients in the country, in other Latin American countries, and in similar contexts. Understanding medication utilization in different countries and contexts is essential for achieving greater rationality in drug use especially for AM.
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