Background
Methods
Setting
Study population
Genotyping
Investigation of epidemiologic links
Statistics
Results
Characteristics of enrolled subjects
Characteristics | All n = 42 | Clustered infection n = 32 | Individual infection n = 10 |
P value |
---|---|---|---|---|
Demographic data | ||||
Age (years) |
76.5 (33.8)
|
62.3 (35.2)
|
85.8 (5.1)
|
P < 0.01 |
Male (%) | 27 (64.3) | 8 (56.2) | 9 (90.0) |
P = 0.07 |
Body mass index(kg/m2) |
20.3 (1.9)
|
20.8 (4.7)
|
19.6 (2.6)
|
P = 0.15 |
Dependent activity of daily living | 18 (42.9) | 8 (25.0) | 9 (90.0) |
P < 0.01 |
Nasogastric tube feeding % | 17 (40.5) | 8 (25.0) | 9 (90.0) |
P < 0.01 |
Foley insertion % | 17 (40.5) | 8 (25.0) | 9 (90.0) |
P < 0.01 |
Tracheostomy % | 15 (35.7) | 9 (28.1) | 6 (60.0) |
P = 0.07 |
TB severity | ||||
Cavity on chest X-ray | 4 (9.5) | 4 (12.5) | 0(0.0) |
P = 0.56 |
Positive sputum smear | 6 (14.3) | 5 (15.6) | 1 (10.0) |
P = 0.56 |
Underlying diseases | ||||
Hypertension % | 18 (42.9) | 13 (40.6) | 5 (50.0) |
P = 0.72 |
Diabetes mellitus % | 8 (19.0) | 7 (21.9) | 1 (10.0) |
P = 0.66 |
Congestive heart failure % | 7 (16.7) | 5 (15.6) | 2 (20.0) |
P = 0.54 |
Chronic renal failure (Cr > 2) % | 6 (14.3) | 5 (15.6) | 1 (10.0) |
P = 0.56 |
Old stroke | 6 (38.1) | 11 (34.4) | 5 (50.0) |
P = 0.47 |
Chronic obstructive pulmonary disease % | 8 (19.0) | 4 (12.5) | 4 (40.0) |
P = 0.08 |
Hepatitis B virus carrier | 2 (4.8) | 2 (6.7) | 0(0.0) |
P = 0.56 |
Hepatitis C virus carrier | 4 (9.5) | 3 (10.0) | 1 (10.0) |
P = 0.74 |
Laboratory data | ||||
White blood cell count (cells/μl) |
7140 (2680)
|
7315 (2937)
|
6930 (1178)
|
P = 0.31 |
Hemoglobin (g/dL) |
11.4 (2.1)
|
11.4 (2.1)
|
11.4 (1.7)
|
P = 0.57 |
Platelet (103/μl) |
238 (101)
|
247 (116)
|
215 (69)
|
P = 027 |
Creatinine (mg/dL) |
0.8 (0.3)
|
0.8 (0.5)
|
0.7 (0.3)
|
P = 0.22 |
Albumin (mg/dL) |
3.4 (0.9)
|
3.4 (1.0)
|
3.4 (0.5)
|
P = 0.63 |
Characteristics | Univariate | Multivariate | ||
---|---|---|---|---|
P value | OR (95% C.I.) |
P value | OR (95% C.I.) | |
Age, per 1 year increment | 0.012 | 1.091 (1.020–1.167) | 0.334 | 1.045 (0.956–1.141) |
Sex, male | 0.037 | 10.00 (1.151–86.876) | 0.388 | 3.234 (0.225–46.411) |
BMI, per 1 year increment(kg/m2) | 0.194 | 0.857 (0.679–1.081) | 0.762 | 0.959 (0.729–1.261) |
ADL-dependence | 0.002 | 0.030 (0.003–0.270) | 0.028 | 0.073 (0.007–0.758) |
COPD | 0.038 | 0.176 (0.034–0.905) | 0.991 | 1.012 (0.120–8.576) |
Added value of prolonged genotyping surveillance on the epidemiological investigation
Cluster | Person | CXR | Sputum | No | Time | Place of contact | |
---|---|---|---|---|---|---|---|
Cavity (+) | Smear (+) | (days) | Ward | Section | |||
Overall | 2nd subjects | - | - | 27 |
673 (812)
| 14 (43.8%) | 22 (68.7%) |
1 | Indexsubject | Yes | Yes | ||||
2nd subjects | 22 |
499 (786)
| 10 (45.5%) | 17 (77.3%) | |||
2 | Indexsubject | No | Yes | ||||
2nd subject | 1 | 848 | 1 (100%) | 1 (100%) | |||
3 | Indexsubject | Yes | Yes | ||||
2nd subjects | 2 |
1511 (329)
| 2 (100%) | 2 (100%) | |||
4 | Indexsubject | No | Yes | ||||
2nd subject | 1 | 217 | 0 (0%) | 1 (100%) | |||
5 | Indexsubject | No | Yes | ||||
2nd subject | 1 | 107 | 1 (100%) | 1 (100%) |