Erschienen in:
01.08.2011 | Book Review
Vaccine design: Innovative Approaches and Novel Strategies Edited by Rino Rappuoli and Fabio Bagnoli (2011)
Caister Academic Press, Norfolk, UK, 380 pages. ISBN :978-1-904455-74-5, Hardcover. $319 from Amazon.com
verfasst von:
Marc van Regenmortel
Erschienen in:
Archives of Virology
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Ausgabe 8/2011
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Excerpt
This timely book reviews major advances in the field of bacterial vaccines made possible by the increasing number of whole genome sequences of bacterial pathogens determined in the last 15 years. Following an introductory chapter by Ruth Arnon of the Weizmann Institute describing various vaccine strategies used against microbial diseases, Chapter 2 by Rino Rappuoli and his colleagues from Novartis Vaccines in Siena, gives a comprehensive overview of a new approach known as reverse vaccinology. This approach, introduced ten years ago, was called reverse vaccinology because it does not search for vaccine candidates by the classical approach of fractionating bacterial extracts and establishing which antigens are able to induce a protective immune response, but by predicting potential vaccine immunogens using bioinformatic analyses of entire bacterial genomes. …