Background
Methods
Translation of the long and short forms of the UCT questionnaires
Clinical measures
Subjects
Statistical analysis
Results
Construct and known-groups validity
Construct validity (correlations) | Urticaria Control Test | |
---|---|---|
Long Form | Short Form | |
Urticaria Activity Score (UAS28) | −0.67* | −0.68* |
Patient’s global assessment of disease severity (PatGA-VAS) | −0.81* | −0.72* |
Patient’s global assessment disease control (PatGA-LS) | 0.76* | 0.83* |
Physician’s global assessment of disease control (PhyGA-VAS) | 0.71* | 0.77* |
Validated Thai version of Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) | −0.89* | −0.78* |
Known-groups validity | Urticaria Control Test | |||||
---|---|---|---|---|---|---|
Long Form | Short Form | |||||
Urticaria Activity Score (UAS28) |
n of patients
|
Mean (SD) |
Median
|
n of patients
|
Mean (SD) |
Median
|
UAS28 ≤ 10 | 55 | 29.1 (3.3) | 30.0 | 55 | 14.1 (2.0) | 15.0 |
UAS28 = 11-35 | 61 | 24.5 (4.7) | 25.0 | 61 | 11.5 (2.4) | 12.0 |
UAS28 = 36-70 | 31 | 20.0 (5.8) | 21.0 | 31 | 8.7 (2.8) | 9.0 |
UAS28 = 71-105 | 14 | 19.9 (5.0) | 20.0 | 14 | 8.8 (2.2) | 8.0 |
UAS28 ≥ 106 | 8 | 13.5 (6.9) | 14.0 | 8 | 5.8 (3.1) | 5.0 |
Internal consistency and test-retest reliability
Screening accuracy (Categorization)
Thai UCT score (Long Form) | Patient’s global assessment of disease control (PatGA-LS) | |||
2nd visit | 3rd visit | |||
Well-controlled patients (n = 100) | Well-controlled patients (n = 94) | |||
Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | |
20.0 | 75.2 | 81.3 | 92.9 | 44.7 |
21.0 | 77.0 | 76.8 | 92.9 | 53.2 |
22.0 | 76.8 | 75.4 | 89.8 | 59.6 |
23.0 | 81.2 | 73.5 | 87.8 | 68.1 |
24.0 |
90.6
|
72.6
|
84.7
|
78.7
|
25.0 |
94.6
|
71.4
|
79.6
|
87.2
|
26.0 | 95.7 | 66.0 | 73.5 | 93.6 |
AUC | 0.89 (0.84-0.94) | 0.90 (0.85-0.95) | ||
Thai UCT score (Short Form) | Patient’s global assessment disease control (PatGA-LS) | |||
2nd visit | 3rd visit | |||
Well-controlled patients (n = 100) | Well-controlled patients (n = 94) | |||
Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | |
9.0 | 67.6 | 93.9 | 95.9 | 48.9 |
10.0 | 72.6 | 91.1 | 93.9 | 63.8 |
11.0 |
76.6
|
84.5
|
90.8
|
80.9
|
12.0 |
92.0
|
84.0
|
79.6
|
93.6
|
13.0 | 97.0 | 70.9 | 61.2 | 97.9 |
AUC (95 % CI) | 0.93 (0.89-0.97) | 0.93 (0.89-0.97) |
Sensitivity to change and interpretability (MCID)
Changes in Long Form Thai UCT score | Patient’s global assessment of disease control (PatGA-LS) score | |||
Change in score of 1 (minimal responders = 20) | Change in score of 2 (marked responders = 9) | |||
Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | |
1.0 | 90.0 | 74.1 | 100 | 64.7 |
2.0 | 90.0 | 81.9 | 100 | 71.3 |
3.0 | 85.0 | 85.3 | 88.9 | 75.0 |
4.0 | 70.0 | 90.5 | 88.9 | 81.6 |
5.0 | 60.0 | 94.8 | 77.8 | 86.8 |
6.0 | 45.0 | 97.4 | 77.8 | 91.2 |
AUC (95 % CI) | 0.86 (0.80-0.98) | 0.92 (0.86-0.99) | ||
Changes in Short Form Thai UCT score | Patient’s global assessment of disease control (PatGA-LS) score | |||
Change in score of 1 (minimal responders = 20) | Change in score of 2 (marked responders = 9) | |||
Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | |
1.0 | 80.0 | 79.3 | 100 | 70.6 |
2.0 | 75.0 | 88.8 | 100 | 79.4 |
3.0 | 60.0 | 95.7 | 88.9 | 87.5 |
4.0 | 40.0 | 97.4 | 77.8 | 91.9 |
5.0 | 20.0 | 99.1 | 77.8 | 96.3 |
AUC (95 % CI) | 0.84 (0.80-0.97) | 0.96 (0.92-0.99) |
Long Form of the Thai UCT | |||||
Total mean score (SD.) | Between minimal responders and non-responders | Between marked responders and non-responders | |||
Baseline (n = 169) | Week 4 (n = 169) | Mean score (SD.) of minimal responders (n = 20) | Mean score (SD.) of non-responders (n = 116) | Mean score (SD.) of marked responders (n = 9) | Mean score (SD.) of non-responders (n = 136) |
22.72 (6.57) | 24.27 (6.27) | 6.5 (7.3) | 0.6 (2.7) | 11.1 (7.2) | 1.5 (2.7) |
The differences of mean scores | 5.9 | 9.6 | |||
Short Form of the Thai UCT | |||||
Total mean score (SD.) | Between minimal responders and non-responders | Between marked responders and non-responders | |||
Baseline (n = 169) | Week 4 (n = 169) | Mean score (SD.) of minimal responders (n = 20) | Mean score (SD.) of non-responders (n = 116) | Mean score of marked responders (n = 9) | Mean score of non-responders (n = 136) |
10.79 (3.31) | 11.31 (3.36) | 3.0 (2.7) | 0.2 (1.3) | 6.3 (2.7) | 0.6 (1.9) |
The differences of mean scores | 2.8 | 5.8 |