Skip to main content
Erschienen in: Documenta Ophthalmologica 2/2024

14.02.2024 | Original Research Article

Videoocular assessment of eye movement activity in an ataxia–telangiectasia: a case study

verfasst von: Sofia A. Mironets, Marina A. Shurupova, Alexander F. Karelin

Erschienen in: Documenta Ophthalmologica | Ausgabe 2/2024

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Ataxia–telangiectasia (A–T) is an autosomal recessive disorder characterized by progressive neurological deficits, including prominent oculomotor dysfunction. We report 5 cases of eye movement assessment in children 9–15 years old with A–T.

Methods

Three different oculomotor tasks (gaze holding, visually guided saccades and visual search) were used, and video-oculography was performed. Additionally, the scale for the assessment and rating of ataxia (SARA) score was used to assess severity of the cerebellar ataxia.

Results

Unstable gaze holding, nystagmus and saccadic intrusions were found. In addition to psychophysiological assessment results, we provide quantitative analysis of oculomotor activity, revealing a specific abnormal oculomotor pattern, consisting of (i) marked saccade hypermetria, (ii) unstable gaze holding, and (iii) gaze-evoked nystagmus.

Conclusion

Our study opens the prospect to evaluate efficacy and safety of alternative methods for supporting the patient and improving his/her life quality.
Literatur
3.
Zurück zum Zitat Lewis RF, Lederman HM, Crawford TO (2002) Slow target-directed eye movements in ataxia–telangiectasia. Invest Ophthalmol Vis Sci 43:686–691PubMed Lewis RF, Lederman HM, Crawford TO (2002) Slow target-directed eye movements in ataxia–telangiectasia. Invest Ophthalmol Vis Sci 43:686–691PubMed
6.
Zurück zum Zitat Gatti RA, Vinters HV (1985) Cerebellar pathology in ataxia–telangiectasia: the significance of basket cells. Kroc Found Ser 19:225–232PubMed Gatti RA, Vinters HV (1985) Cerebellar pathology in ataxia–telangiectasia: the significance of basket cells. Kroc Found Ser 19:225–232PubMed
7.
Zurück zum Zitat Vinters HV, Gatti RA, Rakic P (1985) Sequence of cellular events in cerebellar ontogeny relevant to expression of neu- ronal abnormalities in ataxia–telangiectasia. Kroc Found Ser 19:233–255PubMed Vinters HV, Gatti RA, Rakic P (1985) Sequence of cellular events in cerebellar ontogeny relevant to expression of neu- ronal abnormalities in ataxia–telangiectasia. Kroc Found Ser 19:233–255PubMed
20.
Zurück zum Zitat Shurupova MA, Anisimov VN, Tereshchenko LV, Latanov AV (2016) Vliyanie kognitivnoi zadachi na parametry dvizhenii glaz pri prosmotre staticheskikh i dinamicheskikh stsen [Eye movement parameters are influenced by cognitive task in viewing of static and dynamic scenes]. Sensornye Sistemy [Sens Syst] 30(1):53–62 (in Russian) Shurupova MA, Anisimov VN, Tereshchenko LV, Latanov AV (2016) Vliyanie kognitivnoi zadachi na parametry dvizhenii glaz pri prosmotre staticheskikh i dinamicheskikh stsen [Eye movement parameters are influenced by cognitive task in viewing of static and dynamic scenes]. Sensornye Sistemy [Sens Syst] 30(1):53–62 (in Russian)
Metadaten
Titel
Videoocular assessment of eye movement activity in an ataxia–telangiectasia: a case study
verfasst von
Sofia A. Mironets
Marina A. Shurupova
Alexander F. Karelin
Publikationsdatum
14.02.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
Documenta Ophthalmologica / Ausgabe 2/2024
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-024-09964-z

Weitere Artikel der Ausgabe 2/2024

Documenta Ophthalmologica 2/2024 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.