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Drugs
Erschienen in: Drugs 5/2014

01.04.2014 | Adis Drug Evaluation

Vildagliptin: A Review of Its Use in Type 2 Diabetes Mellitus

verfasst von: Gillian M. Keating

Erschienen in: Drugs | Ausgabe 5/2014

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Abstract

The dipeptidyl peptidase-4 inhibitor vildagliptin (Galvus®) is approved for use as monotherapy and combination therapy in type 2 diabetes mellitus. A fixed-dose combination of vildagliptin/metformin (Eucreas®) is also available. This article reviews the clinical efficacy and tolerability of vildagliptin in the treatment of type 2 diabetes, as well as summarizing its pharmacological properties. Results of randomized controlled trials demonstrated that oral vildagliptin improved glycaemic control when administered as monotherapy, as dual therapy in combination with metformin, a sulfonylurea or a thiazolidinedione, as triple therapy in combination with metformin plus a sulfonylurea, and in combination with insulin with or without metformin. Improvements in glycaemic control were also seen with vildagliptin in elderly patients with type 2 diabetes and in patients with type 2 diabetes and moderate or severe renal impairment. Vildagliptin was generally well tolerated in patients with type 2 diabetes, was weight neutral and was associated with a low risk of hypoglycaemia, reflecting its glucose-dependent mechanism of action. Thus, oral vildagliptin is a useful option as monotherapy or as add-on therapy for patients with type 2 diabetes.
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Metadaten
Titel
Vildagliptin: A Review of Its Use in Type 2 Diabetes Mellitus
verfasst von
Gillian M. Keating
Publikationsdatum
01.04.2014
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 5/2014
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-014-0199-3

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