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31.05.2018 | Vitamin-B12-Mangel | Zertifizierte Fortbildung

Vitamin-B12-Mangel

Zu spät erkannt — zu spät gebannt

verfasst von: Prof. Dr. med. Dipl.-Psych. Ralf Ihl

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 3/2018

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Zusammenfassung

Vitamin B12 regeneriert Neuronen und andere Körperzellen und spielt eine wichtige Rolle im Metabolismus von Proteinen und Neurotransmittern. Die Folge eines Mangelzustandes — etwa bei zu geringer Aufnahme oder verringerter Resorption — kann zum Beispiel eine Demenz oder Depression sein. Das Wichtigste zu klinischen Symptomen, Diagnose, Ursachen und Behandlung eines B12-Mangels.

Gille D, Schmid A. Vitamin B12 in meat and dairy products. Nutr Rev. 2015; 73(2):106–15CrossRefPubMed

Grober U, Kisters K, Schmidt J Neuroenhancement with Vitamin B12 -Underestimated Neurological Significance Nutrients 2013; 5: 5031–45PubMed

Herrmann W, Obeid R. Causes and early diagnosis of vitamin B12 deficiency. Dtsch Arztebl Int 2008; 5(40):680–5

Herrmann W, Obeid R. Cobalamin deficiency. Subcell Biochem 2012; 56:301–22CrossRefPubMed

Herrmann W, Obeid R. Utility and limitations of biochemical markers of vitamin B12 deficiency. Eur J Clin Invest 2013; 43(3):231–7CrossRefPubMed

Hannibal L, Lysne V, Bjorke-Monsen AL, Behringer S, Grunert SC, Spiekerkoetter, Jacobsen DW, Blom. Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency. Front Mol Biosci 2016; 3:27CrossRefPubMedPubMedCentral

Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J 1993; 7(14):1344–53CrossRefPubMed

Golding PH. Holotranscobalamin (HoloTC, Active-B12) and Herbertes model for the development of vitamin B12 deficiency: a review and alternative hypothesis. Springerplus 2016; 5(1):668.CrossRefPubMedPubMedCentral

Iqbal N, Azar D, Yun YM, Ghausi O, Ix J, Fitzgerald RL. Serum methylmalonic acid and holotranscobalamin-II as markers for vitamin B12 deficiency in end-stage renal disease patients. Ann Clin Lab Sci 2013; 43(3):243–9PubMed

10.

Jeruszka-Bielak M, Isman C, Schroder TH, Li W, Green TJ, Lamers Y. South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women. Nutrients 2017; 9(4)

11.

Pennypacker LC, Allen RH, Kelly JP, Matthews LM, Grigsby J, Kaye K, Lindenbaum J, Stabler SP. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992; 40(12):1197–204CrossRefPubMed

12.

Obeid R, Schorr H, Eckert R, Herrmann W. Vitamin B12 status in the elderly as judged by available biochemical markers. Clin Chem 2004; 50(1):238–41CrossRefPubMed

13.

Herrmann W, Obeid R, Schorr H, Geisel J. The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings. Curr Drug Metab 2005; 6(1):47–53CrossRefPubMed

14.

Leischker AH, Kolb GF. Vitamin B12 deficiency in the elderly. Z Gerontol Geriatr 2015; 48(1):73–88; quiz 89-90CrossRefPubMed

15.

Kalkan C, Karakaya F, Tuzun A, Gencturk ZB, Soykan I. Factors related to low serum vitamin B12 levels in elderly patients with non-atrophic gastritis in contrast to patients with normal vitamin B12 levels. Geriatr Gerontol Int 2016; 16(6):686–92CrossRefPubMed

16.

Gueant JL, Coelho D, Nicolas JP. [Vitamin B12 and related genetic disorders]. Bull Acad Natl ed. 2014; 198(6):1141–56

17.

Clarke R, Birks J, Nexo E, Ueland PM, Schneede J, Scott J, Molloy A, Evans JG. Low vitamin B-12 status and risk of cognitive decline in older adults. Am J Clin Nutr 2007; 86(5):1384–91CrossRefPubMed

18.

Health Quality Ontario. Vitamin B12 and cognitive function: an evidence-based analysis. Ont Health Technol Assess Ser 2013; 13(23):1-45

19.

Camarero-Shelly M. Vitamin B(12) levels in the patient population attending an urban health centre in Madrid. Semergen. 2017; pii: S1138-3593(17)30087-4

20.

Moore E, Mander A, Ames D, Carne R, Sanders K, Watters D. Cognitive impairment and vitamin B12: a review. Int Psychogeriatr 2012; 24(4):541–56CrossRefPubMed

21.

Vogiatzoglou A, Smith AD, Nurk E, Drevon CA, Ueland PM, Vollset SE, Nygaard HA, Engedal K, Tell GS, Refsum H. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study. Psychosom Med 2013; 75(1):20–9CrossRefPubMed

22.

Hsu YH, Huang CF, Lo CP, Wang TL, Tu MC. Vitamin B12 deficiency: Characterization of psychometrics and MRI morphometrics. Nutr Neurosci 2016; 19(2):47–54CrossRefPubMed

23.

McCaddon A, Miller JW. Assessing the association between homocysteine and cognition: reflections on Bradford Hill, meta-analyses, and causality. Nutr Rev 2015; 73(10):723–35CrossRefPubMed

24.

Vogiatzoglou A, Refsum H, Johnston C, Smith SM, Bradley KM, de Jager C, Budge MM, Smith AD. Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology 2008; 71(11): 826–32CrossRef

25.

Hooshmand B, Mangialasche F, Kalpouzos G, Solomon A, Kareholt I, Smith AD, Refsum H, Wang R, Muhlmann M, Ertl-Wagner B, Laukka EJ, Backman L, Fratiglioni L, Kivipelto M. Association of Vitamin B12, Folate, and Sulfur Amino Acids with Brain Magnetic Resonance Imaging Measures in Older Adults: A Longitudinal Population-Based Study. JAMA Psychiatry 2016; 73(6):606–13CrossRefPubMed

26.

Kwok T, Lee J, Ma RC, Wong SY, Kung K, Lam A, Ho CS, Lee V, Harrison J, Lam L. A randomized placebo controlled trial of vitamin B(12) supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B(12). Clin Nutr 2017; 36(6):1509–15CrossRefPubMed

27.

Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimeres disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci USA 2013; 110(23):9523–8CrossRefPubMed

28.

Kobe T, Witte AV, Schnelle A, Grittner U, Tesky VA, Pantel J, Schuchardt JP, Hahn A, Bohlken J, Rujescu D, Floel A. Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment. Am J Clin Nutr 2016; 103(4):1045–54CrossRefPubMed

29.

Gupta L, Gupta RK, Gupta PK, Malhotra HS, Saha I, Garg RK. Assessment of brain cognitive unctions in patients with vitamin B12 deficiency using resting state functional MRI: A longitudinal study.} Magn Reson Imaging 2016; 34(2):191–6CrossRefPubMed

30.

Spence JD. Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke. Nutr Res 2016; 36(2):109–16CrossRefPubMed

31.

Mizrahi EH, Lubart E, Leibovitz A. Low Borderline Levels of Serum Vitamin B12 May Predict Cognitive Decline in Elderly Hip Fracture Patients. Isr Med Assoc J 2017; 19(5):305–8PubMed

32.

Lewerin, C, Ljungman, S, and Nilsson-Ehle, H. Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly. J Intern Med 2007; 261:65–73CrossRefPubMed

33.

Couderc AL, Camalet J, Schneider S, Turpin JM, Bereder I, Boulahssass R, Gonfrier S, Bayer P, Guerin O, Brocker P. Cobalamin deficiency in the elderly: aetiology and management: a study of 125 patients in a geriatric hospital. J Nutr Health Aging 2015; 19(2): 234–9CrossRefPubMed

34.

Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin? — clearing the confusion. Eur J Clin Nutr 2015; 69(1):1–2CrossRefPubMed

35.

Albers U, Pedrero-Chamizo R, Melendez A, Pietrzik K, Castillo MJ, Gonzalez-Gross M. Efficacy of a 28-day oral cyanocobalamin supplementation on vitamin B status in Spanish institutionalized elderly. Int J Vitam Nutr Res 2012; 82(2):104–12CrossRefPubMed

36.

Houle SK, Kolber MR, Chuck AW. Should vitamin B12 tablets be included in more Canadian drug formularies? An economic model of the cost-saving potential from increased utilisation of oral versus intramuscular vitamin B12 maintenance therapy for Alberta seniors. BMJ Open 2014; 4(5):e004501CrossRefPubMedPubMedCentral

37.

Masucci L, Goeree R. Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis. Ont Health Technol Assess Ser 2013; 13(24):1–24. Available from: http://www.hqontario.ca/evidence/publications-and-ohtac-recommendations/ontario-health-technology-assessment-series/B12-injection-vs-oral-budget-analysis

38.

Tsiachristas A, Smith AD. B-vitamins are potentially a cost-effective population health strategy to tackle dementia: Too good to be true? Alzheimers Dement (N Y). 2016; 2(3):156–61

39.

Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A, Miller JW, Rosenberg IH, Obeid R. Homocysteine and Dementia: An International Consensus Statement. J Alzheimers Dis 2018; 62(2):561–570CrossRefPubMedPubMedCentral

40.

Oh R, Brown DL. Vitamin B12 deficiency. Am Fam Physician 2003; 67(5):979–86PubMed

41.

Palacios, G., Sola, R., Barrios, L., Pietrzik, K., Castillo, M. J., and Gonzalez-Gross, M. Algorithm for the early diagnosis of vitamin B12 deficiency in elderly people. Nutr Hosp 2013; 28: 1447–52PubMed

42.

Baumgartner, M. R., and Fowler, B. Physicianfs Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases. Heidelberg: Springer-Verlag Berlin Heidelberg. 2014

43.

Kocaoglu C, Akin F, Caksen H, Boke SB, Arslan S, Aygun S. Cerebral atrophy in a vitamin B12-deficient infant of a vegetarian mother. J Health Popul Nutr. 2014; 32(2):367–71PubMedPubMedCentral

Titel: Vitamin-B12-Mangel
Zu spät erkannt — zu spät gebannt
verfasst von: Prof. Dr. med. Dipl.-Psych. Ralf Ihl
Publikationsdatum: 31.05.2018
Verlag: Springer Medizin
Schlagwort: Vitamin-B12-Mangel
Erschienen in: DNP – Die Neurologie & Psychiatrie / Ausgabe 3/2018
Print ISSN: 2731-8168
Elektronische ISSN: 2731-8176
DOI: https://doi.org/10.1007/s15202-018-1881-1

Springer Medizin

Zusammenfassung

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