Erschienen in:
14.08.2017 | Management of Heart Failure (T Meyer, Section Editor)
Vitamin D and Heart Failure
verfasst von:
D. Marshall Brinkley, Omair M. Ali, Sandip K. Zalawadiya, Thomas J. Wang
Erschienen in:
Current Heart Failure Reports
|
Ausgabe 5/2017
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Abstract
Purpose
Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure.
Recent Findings.
Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality. However, trials assessing the influence of vitamin D supplementation on surrogate markers and clinical outcomes in heart failure have generally been small and inconclusive.
Summary
There are insufficient data to recommend routine assessment or supplementation of vitamin D for the prevention or treatment of chronic heart failure. Prospective trials powered for clinical outcomes are warranted.