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Current Diabetes Reports

Erschienen in:

01.12.2012 | Hot Topic

Vitamin D, Immune Tolerance, and Prevention of Type 1 Diabetes

verfasst von: Klaus Badenhoop, Heinrich Kahles, Marissa Penna-Martinez

Erschienen in: Current Diabetes Reports | Ausgabe 6/2012

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Abstract

Vitamin D is a secosteroid hormone that resembles other nuclear steroid hormones such as thyroid, gluco-, and mineralocorticoids, as well as gonadal effector systems. Primarily understood as a master regulator of bone and calcium/phosphate physiology, it is now increasingly recognized as orchestrating numerous aspects of cell growth and differentiation in many tissues, including those of innate and acquired immunity. This review addresses recently discovered aspects that highlight vitamin D´s potential for immune intervention and how the vitamin D pathway is utilized for anti-infective and antineoplastic immunity. This provides the rationale for novel therapeutic strategies in the context both of prevention and of therapy of immune dysregulation in type 1 diabetes.

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Titel: Vitamin D, Immune Tolerance, and Prevention of Type 1 Diabetes
verfasst von: Klaus Badenhoop
Heinrich Kahles
Marissa Penna-Martinez
Publikationsdatum: 01.12.2012
Verlag: Current Science Inc.
Erschienen in: Current Diabetes Reports / Ausgabe 6/2012
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-012-0322-3

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