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Journal of Diabetes & Metabolic Disorders
Erschienen in: Journal of Diabetes & Metabolic Disorders 1/2021

25.01.2021 | Review article

Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies

verfasst von: Surendar Aravindhan, Mohammed Fadhil Mohammed Almasoody, Nihad Abdallah Selman, Alekhina Natalia Andreevna, Sahithya Ravali, Payam Mohammadi, Mohammad Masoud Eslami, Bahman Razi, Saeed Aslani, Danyal Imani

Erschienen in: Journal of Diabetes & Metabolic Disorders | Ausgabe 1/2021

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Abstract

Background

Evidence from various studies suggest that vitamin D receptor (VDR) gene polymorphisms are associated with type 2 diabetes (T2D); However, these results have been disputable. Here we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms and susceptibility to T2D.

Methods

All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T2D published up to August 2020 were identified by comprehensive systematic database search in web of science, Scopus, and Medline. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure strength of association. The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup and meta-regression analysis were also performed.

Results

A total of 47 case–control studies were included in this meta-analysis. The overall population results revealed a significant association between FokI, and BsmI (heterozygote model) polymorphisms and T2D in the overall analysis. However, no association was found with the TaqI and ApaI polymorphisms. Moreover, the pooled results of subgroup analysis by ethnicity suggested significant association between FokI, TaqI, and BsmI polymorphisms and T2D in some subgroups. Meta-regression analyses indicated that none of the publication year, ethnicity, and genotyping method were the source of heterogenicity in all four polymorphisms.

Conclusions

This meta-analysis suggested a significant association between VDR gene FokI, and BsmI (heterozygote model) polymorphisms and T2D susceptibility in overall population and ethnic-specific analysis.
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Metadaten
Titel
Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies
verfasst von
Surendar Aravindhan
Mohammed Fadhil Mohammed Almasoody
Nihad Abdallah Selman
Alekhina Natalia Andreevna
Sahithya Ravali
Payam Mohammadi
Mohammad Masoud Eslami
Bahman Razi
Saeed Aslani
Danyal Imani
Publikationsdatum
25.01.2021
Verlag
Springer International Publishing
Erschienen in
Journal of Diabetes & Metabolic Disorders / Ausgabe 1/2021
Elektronische ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-020-00704-z

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