Skip to main content
Erschienen in: International Urogynecology Journal 12/2012

01.12.2012 | Original Article

Vitamin D status in women with pelvic floor disorder symptoms

verfasst von: Candace Y. Parker-Autry, Alayne D. Markland, Alicia C. Ballard, Deidra Downs-Gunn, Holly E. Richter

Erschienen in: International Urogynecology Journal | Ausgabe 12/2012

Einloggen, um Zugang zu erhalten

Abstract

Introduction and hypothesis

Our aim was to characterize the relationship between 25-hydroxyvitamin D [25(OH)D] status with pelvic floor symptom distress and impact on quality of life.

Methods

A retrospective chart review was performed in women with a 25(OH)D level drawn within 1 year of their gynecology/urogynecology visit. Validated questionnaires including the Colorectal–Anal Distress Inventory (CRADI)-8 and Incontinence Impact Questionnaire (IIQ-7) were used. Multivariate analyses characterized pelvic floor disorder (PFD) symptom differences among women by vitamin D status.

Results

We studied 394 women. Mean ± standard deviation (SD) 25(OH)D levels were higher in women without than with PFD symptoms (35.0 ± 14.1 and 29.3 ± 11.5 ng/ml, respectively (p < 0.001)]. The prevalence of vitamin D insufficiency was 51% (136/268). CRADI-8 and IIQ-7 scores were higher among women with vitamin D insufficiency (p = 0.03 and p = 0.001, respectively). Higher IIQ-7 scores were independently associated with vitamin D insufficiency (p < 0.001).

Conclusions

Insufficient vitamin D is associated with increased colorectal symptom distress and greater impact of urinary incontinence on quality of life.
Literatur
1.
Zurück zum Zitat Kumar J, Muntner P, Kaskel FJ, Hailper SM, Melamed ML (2009) Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004. Pediatrics 124:362–370CrossRef Kumar J, Muntner P, Kaskel FJ, Hailper SM, Melamed ML (2009) Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004. Pediatrics 124:362–370CrossRef
2.
Zurück zum Zitat Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Haff Fuleihan G, Josse RG, Lips P, Morales-Torres J (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820PubMedCrossRef Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Haff Fuleihan G, Josse RG, Lips P, Morales-Torres J (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820PubMedCrossRef
3.
Zurück zum Zitat Badalian SS, Rosenbaum PF (2010) Vitamin D and pelvic floor disorders in women: results from the National Health and Nutrition Examination Survey. Obstet Gynecol 115:795–803PubMedCrossRef Badalian SS, Rosenbaum PF (2010) Vitamin D and pelvic floor disorders in women: results from the National Health and Nutrition Examination Survey. Obstet Gynecol 115:795–803PubMedCrossRef
4.
Zurück zum Zitat Holick MF, Chen TC, Lu Z, Sauter E (2007) Vitamin D and skin physiology: a D-lightful story. J Bone Miner Res 22(S2):V28–V33PubMedCrossRef Holick MF, Chen TC, Lu Z, Sauter E (2007) Vitamin D and skin physiology: a D-lightful story. J Bone Miner Res 22(S2):V28–V33PubMedCrossRef
5.
Zurück zum Zitat Wang S (2009) Epidemiology of vitamin D in health and disease. Nutr Res Rev 188–203 Wang S (2009) Epidemiology of vitamin D in health and disease. Nutr Res Rev 188–203
6.
Zurück zum Zitat Hanley DA, Davison KS (2005) Vitamin D insufficiency in North America. J Nutr 135:332–337PubMed Hanley DA, Davison KS (2005) Vitamin D insufficiency in North America. J Nutr 135:332–337PubMed
7.
Zurück zum Zitat Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J, Balk EM (2010) Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med 152:307–314PubMed Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J, Balk EM (2010) Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med 152:307–314PubMed
8.
Zurück zum Zitat Allan K, Devereux G (2011) Diet and asthma: nutrition implications from prevention to treatment. J Am Diet Assoc 111(2):258–268PubMedCrossRef Allan K, Devereux G (2011) Diet and asthma: nutrition implications from prevention to treatment. J Am Diet Assoc 111(2):258–268PubMedCrossRef
9.
Zurück zum Zitat Shand AW, Nassar N, Von Dadelszen P, Innis SM, Green TJ (2010) Maternal vitamin D status in pregnancy and advese pregnancy outcomes in a group of high risk for pre-eclampsia. Br J Obstet Gynaecol 117(13):1593–1598CrossRef Shand AW, Nassar N, Von Dadelszen P, Innis SM, Green TJ (2010) Maternal vitamin D status in pregnancy and advese pregnancy outcomes in a group of high risk for pre-eclampsia. Br J Obstet Gynaecol 117(13):1593–1598CrossRef
10.
Zurück zum Zitat Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C (2000) Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 15:1113–1118PubMedCrossRef Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C (2000) Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 15:1113–1118PubMedCrossRef
11.
Zurück zum Zitat Bischoff HA, Stahelin HB, Dick W, Akos R, Kneht M, Salis C, Nebiker M, Cheiler R, Pfeifer M, Beqerow B, Lew RA, Conzelmann M (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343–351PubMedCrossRef Bischoff HA, Stahelin HB, Dick W, Akos R, Kneht M, Salis C, Nebiker M, Cheiler R, Pfeifer M, Beqerow B, Lew RA, Conzelmann M (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343–351PubMedCrossRef
12.
Zurück zum Zitat Ward KA, Das G, Roberts SA, Berry JL, Adams JE, Rawer R, Mughal MZ (2010) A randomized, controlled trial of vitamin D supplementation upon musculoskeletal health in postmenarchal females. J Clin Endocrinol Metab 95(10):0000–0000CrossRef Ward KA, Das G, Roberts SA, Berry JL, Adams JE, Rawer R, Mughal MZ (2010) A randomized, controlled trial of vitamin D supplementation upon musculoskeletal health in postmenarchal females. J Clin Endocrinol Metab 95(10):0000–0000CrossRef
13.
Zurück zum Zitat Lips P, Binkley N, Pfeifer M, Recker R, Samanta S, Cohn DA, Chandler J, Rosenberg E, Papanicolaou DA (2010) Once-weekly dose of 8400 IU vitamin D(3) compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D insufficiency. Am J Clin Nutr 91(4):985–991PubMedCrossRef Lips P, Binkley N, Pfeifer M, Recker R, Samanta S, Cohn DA, Chandler J, Rosenberg E, Papanicolaou DA (2010) Once-weekly dose of 8400 IU vitamin D(3) compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D insufficiency. Am J Clin Nutr 91(4):985–991PubMedCrossRef
14.
Zurück zum Zitat Dhesi JK, Jackson SH, Bearne LM, Moniz C, Hurley MV, Swift CG, Allain TJ (2004) Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing 33(6):589–595PubMedCrossRef Dhesi JK, Jackson SH, Bearne LM, Moniz C, Hurley MV, Swift CG, Allain TJ (2004) Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing 33(6):589–595PubMedCrossRef
15.
Zurück zum Zitat Crescioli C, Morelli A, Adorini L, Ferruzzi P, Luconi M, Vannelli GB, Marini M, Gelmini S, Fibbi B, Donati S, Villari D, Forti G, Colli E, Andersson KE, Maggi M (2005) Human bladder as a novel target for vitamin D receptor ligands. J Clin Endocrinol Metab 90:962–972PubMedCrossRef Crescioli C, Morelli A, Adorini L, Ferruzzi P, Luconi M, Vannelli GB, Marini M, Gelmini S, Fibbi B, Donati S, Villari D, Forti G, Colli E, Andersson KE, Maggi M (2005) Human bladder as a novel target for vitamin D receptor ligands. J Clin Endocrinol Metab 90:962–972PubMedCrossRef
16.
Zurück zum Zitat Zerwekh JE (2008) Blood biomarkers of vitamin D status. Am J Clin Nutr 87:1087S–1091SPubMed Zerwekh JE (2008) Blood biomarkers of vitamin D status. Am J Clin Nutr 87:1087S–1091SPubMed
18.
Zurück zum Zitat Hansen KE, Jones AN, Lindstrom MJ, Davis LA, Engelke JA, MM Shafer (2008) Vitamin D insufficiency: disease or no disease? J Bone Miner Res 23:1052–1060PubMedCrossRef Hansen KE, Jones AN, Lindstrom MJ, Davis LA, Engelke JA, MM Shafer (2008) Vitamin D insufficiency: disease or no disease? J Bone Miner Res 23:1052–1060PubMedCrossRef
19.
Zurück zum Zitat Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN (2010) An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29:4–20PubMed Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN (2010) An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29:4–20PubMed
20.
Zurück zum Zitat Barber MD, Walters MD, Bump RC (2005) Short forms of two condition-specific quality-of-life questionnaires for women with pelvic floor disorders (PFDI-20 and PFIQ-7). Am J Obstet Gynecol 193:103–113PubMedCrossRef Barber MD, Walters MD, Bump RC (2005) Short forms of two condition-specific quality-of-life questionnaires for women with pelvic floor disorders (PFDI-20 and PFIQ-7). Am J Obstet Gynecol 193:103–113PubMedCrossRef
21.
Zurück zum Zitat Herzog AR, Diokno AC, Brown MB, Normolle DP, Brock BM (1990) Two-year incidence, remission, and change patterns of urinary incontinence in noninstitutionalized older adults. J Gerontol Med Sci 45:M67–M74 Herzog AR, Diokno AC, Brown MB, Normolle DP, Brock BM (1990) Two-year incidence, remission, and change patterns of urinary incontinence in noninstitutionalized older adults. J Gerontol Med Sci 45:M67–M74
22.
Zurück zum Zitat Shumaker SA, Wyman JF, Uebersax JS, McClish D, Fantl JA (1994) Health-related quality of life measures for women with urinary incontinence: the incontinence impact questionnaire and the urogenital distress inventory. Qual Life Res 3:291–306PubMedCrossRef Shumaker SA, Wyman JF, Uebersax JS, McClish D, Fantl JA (1994) Health-related quality of life measures for women with urinary incontinence: the incontinence impact questionnaire and the urogenital distress inventory. Qual Life Res 3:291–306PubMedCrossRef
23.
Zurück zum Zitat Dallosso HM, McGrother CW, Matthes RU, Donaldson MMK (2004) Nutrient composition of the diet and the development of overactive bladder: a longitudinal study in women. Neurourol Urodyn 23:204–210PubMedCrossRef Dallosso HM, McGrother CW, Matthes RU, Donaldson MMK (2004) Nutrient composition of the diet and the development of overactive bladder: a longitudinal study in women. Neurourol Urodyn 23:204–210PubMedCrossRef
24.
Zurück zum Zitat Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin HB, Dick W (2001) In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J 33:19–24PubMedCrossRef Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin HB, Dick W (2001) In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J 33:19–24PubMedCrossRef
25.
Zurück zum Zitat Bischoff-Ferrari HA, Borchers M, Guddat F, Durmuller U, Stahelin HB, Dick W (2004) Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19:265–269PubMedCrossRef Bischoff-Ferrari HA, Borchers M, Guddat F, Durmuller U, Stahelin HB, Dick W (2004) Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19:265–269PubMedCrossRef
26.
Zurück zum Zitat Wang Y, DeLuca HF (2011) Is the vitamin D receptor found in muscle? Endocrinology 152:354–363PubMedCrossRef Wang Y, DeLuca HF (2011) Is the vitamin D receptor found in muscle? Endocrinology 152:354–363PubMedCrossRef
27.
Zurück zum Zitat Gau JT (2010) Urinary incontinence resolved after adequate vitamin D supplementation: a report of two cases. J Am Geriatr Soc 58(12):2438–2439PubMedCrossRef Gau JT (2010) Urinary incontinence resolved after adequate vitamin D supplementation: a report of two cases. J Am Geriatr Soc 58(12):2438–2439PubMedCrossRef
28.
Zurück zum Zitat Penna G, Fibbi B, Amuchastegui S, Corsiero E, Laverny G, Silvestrini E, Chavalmane A, Morelli A, Sarchielli E, Vannelli GB, Gacci M, Colli E, Maggi M, Adorini L (2009) The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kB pathways. Prostate 69:480–493PubMedCrossRef Penna G, Fibbi B, Amuchastegui S, Corsiero E, Laverny G, Silvestrini E, Chavalmane A, Morelli A, Sarchielli E, Vannelli GB, Gacci M, Colli E, Maggi M, Adorini L (2009) The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kB pathways. Prostate 69:480–493PubMedCrossRef
29.
Zurück zum Zitat Alkhatib AA, Tuteja AK (2010) High prevalence of vitamin D deficiency among patients with fecal incontinence. Dig Dis Sci Alkhatib AA, Tuteja AK (2010) High prevalence of vitamin D deficiency among patients with fecal incontinence. Dig Dis Sci
30.
Zurück zum Zitat Gleason JL, Markland A, Greer WJ, Szychowski JM, Gerten KA, Richter HE (2011) Anal sphincter repair for fecal incontinence: effect on symptom severity, quality of life, and anal sphincter squeeze pressures. Int Urogynecol J 22(12):1587–1592PubMedCrossRef Gleason JL, Markland A, Greer WJ, Szychowski JM, Gerten KA, Richter HE (2011) Anal sphincter repair for fecal incontinence: effect on symptom severity, quality of life, and anal sphincter squeeze pressures. Int Urogynecol J 22(12):1587–1592PubMedCrossRef
Metadaten
Titel
Vitamin D status in women with pelvic floor disorder symptoms
verfasst von
Candace Y. Parker-Autry
Alayne D. Markland
Alicia C. Ballard
Deidra Downs-Gunn
Holly E. Richter
Publikationsdatum
01.12.2012
Verlag
Springer-Verlag
Erschienen in
International Urogynecology Journal / Ausgabe 12/2012
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-012-1700-8

Weitere Artikel der Ausgabe 12/2012

International Urogynecology Journal 12/2012 Zur Ausgabe

Gestationsdiabetes: In der zweiten Schwangerschaft folgenreicher als in der ersten

13.05.2024 Gestationsdiabetes Nachrichten

Das Risiko, nach einem Gestationsdiabetes einen Typ-2-Diabetes zu entwickeln, hängt nicht nur von der Zahl, sondern auch von der Reihenfolge der betroffenen Schwangerschaften ab.

Embryotransfer erhöht womöglich Leukämierisiko der Kinder

13.05.2024 Assistierte Reproduktion Nachrichten

Reproduktionsmedizinische Techniken haben theoretisch das Potenzial, den epigenetischen Code zu verändern und somit das Krebsrisiko der Kinder zu erhöhen. Zwischen Embryotransfer und Leukämie scheint sich ein solcher Zusammenhang bestätigt zu haben.

Alter verschlechtert Prognose bei Endometriumkarzinom

11.05.2024 Endometriumkarzinom Nachrichten

Ein höheres Alter bei der Diagnose eines Endometriumkarzinoms ist mit aggressiveren Tumorcharakteristika assoziiert, scheint aber auch unabhängig von bekannten Risikofaktoren die Prognose der Erkrankung zu verschlimmern.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.