1 Background
2 Methods
2.1 Stage 1: Identifying the research questions
2.2 Stages 2 and 3: Identifying and selecting relevant studies
Inclusion criteria | • Written in English |
• Reports primary research | |
• Concerns ovarian teratoma in pediatric age (0–18 years) | |
• Does not concern lesion other than teratoma (e.g., all germ cell tumors) | |
• Study date 1999–2019 | |
Keywords considered | Ovarian teratoma: Teratoma, Ovarian; Ovarian Neoplasms; Dermoid Cyst, Ovarian; Ovary Neoplasms; Neoplasms, Ovary |
Teratoma: Dysembryoma; Teratoid Tumor; Teratoma, Benign; Teratoma, Cystic; Teratoma, Immature; Teratoma, Malignant; Teratoma, Mature; Benign Neoplasms; Malignancy; Malignant Neoplasms; Neoplasia; Neoplasm; Neoplasms, Benign; Tumors | |
Ovary: Ovaries; Gonads | |
Child: Adolescent; Child, Preschool; Infant; Children; Minors | |
Search strategy in PubMed | 1. ((“Ovarian Neoplasms”[Mesh]) OR (“Teratoma”[Mesh]) AND (“Child”[Mesh]) OR (“ovarian teratoma in children” OR “ovarian teratoma in a child” OR “teratoma of the ovary in a child” OR “ovarian teratoma in children” OR “teratoma of the ovary in children” OR “pediatric ovarian teratoma”) NOT medline[sb]) |
2. ((“Ovarian Neoplasms”[Mesh]) OR (“Teratoma”[Mesh]) AND (“Child”[Mesh]) OR (teratoma* AND child* NOT medline[sb])) | |
Search strategy in Web of Science | 1. # 1 (ALL = (teratoma AND child)) AND LANGUAGE: (English) |
2. # 2 (ALL = (teratoma AND ovary)) AND | |
LANGUAGE: (English) 3. (#1 OR #2) AND LANGUAGE: (English) |
2.3 Stage 4: Charting the data
2.4 Stage 5: Collating, summarizing, and reporting the results
3 Results
TOPIC (main with red color) | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Article No. | Recurrence rate/relapse and follow up strategy | differences between LS and LT | Prognostic factors | Incidence of familiar forms | Possible use of pharmacotherapy | Use of sparing surgery | Malignant potential | Use of contralateral biopsy | Grading | Use and differences in staging procedures | Alpha-fetoprotein (AFP) cutoff level | Imaging features | Use of chemotherapy | Need for central pathology review | Importance of spillage | Gliomatosis peritonei | Associated defects | Additional examinations to test the immature or mature caracter | Discovery of new diagnostic factors - e.g. genotyping | Overall topics included | Mature | Immature | Both |
1 | + | + | 2 | + | |||||||||||||||||||
2 | + | + | + | 3 | + | ||||||||||||||||||
3 | + | + | + | + | + | + | + | + | + | 9 | + | + | |||||||||||
4 | + | + | + | + | 4 | + | + | ||||||||||||||||
5 | + | + | + | + | + | + | 6 | + | |||||||||||||||
6 | + | + | + | + | + | + | 6 | + | + | ||||||||||||||
7 | + | + | + | + | + | + | + | 7 | + | ||||||||||||||
8 | + | + | + | + | 4 | + | + | ||||||||||||||||
9 | + | + | + | ||||||||||||||||||||
10 | + | + | + | + | + | 5 | + | + | |||||||||||||||
11 | + | + | + | 3 | + | ||||||||||||||||||
12 | + | + | + | + | + | 5 | + | + | |||||||||||||||
13 | + | + | + | + | + | 4 | + | + | |||||||||||||||
14 | + | + | + | 3 | + | + | |||||||||||||||||
15 | + | + | + | + | 4 | + | |||||||||||||||||
16 | + | + | + | + | |||||||||||||||||||
17 | + | + | + | 3 | + | ||||||||||||||||||
18 | + | + | + | + | 4 | + | + | ||||||||||||||||
19 | + | 1 | + | + | |||||||||||||||||||
20 | + | + | 2 | + | |||||||||||||||||||
21 | + | + | + | + | + | + | 6 | + | |||||||||||||||
22 | + | + | + | 3 | + | + | |||||||||||||||||
23 | + | + | + | + | 4 | + | + | ||||||||||||||||
24 | + | + | |||||||||||||||||||||
Overall number of the studies | 14 | 6 | 7 | 2 | 1 | 8 | 7 | 3 | 7 | 1 | 3 | 4 | 6 | 6 | 6 | 4 | 1 | 3 | 2 | 17 | 16 | 13 | |
Number of the studies including more than 50 cases | 7 | 4 | 3 | 1 | 1 | 3 | 3 | 1 | 2 | 1 | 1 | 0 | 3 | 2 | 1 | 2 | 1 | 0 | 0 | 3 | 2 | 4 | |
Number of the studies concerning mature teratoma | 3 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | ||||
Number of the studies concerning immature teratoma | 3 | 4 | 3 | 0 | 0 | 1 | 2 | 0 | 3 | 1 | 2 | 1 | 2 | 1 | 0 | 1 | 1 | 1 | 1 | ||||
Number of the studies concerning both types of the tumor | 8 | 2 | 4 | 2 | 1 | 3 | 5 | 1 | 3 | 0 | 1 | 3 | 4 | 4 | 4 | 3 | 0 | 1 | 0 |