Background
Methods
A - Characteristics of the samplea | ||||
N individuals | Age, years ± SD | Gender M:F | ||
Cases / Reaction | 94 | 44.05 (13.31) | 58:36 | |
Controls / No Reaction | 57 | 45.21 (14.98) | 28:29 | |
B - Clinical characteristics of the cohorta | ||||
Clinical phenotype
|
n
|
(%)
| ||
Tuberculoid (TT) | 20 | (13) | ||
Borderline tuberculoid (BT) | 30 | (20) | ||
Borderline (BB) | 18 | (12) | ||
Borderline lepromatous (BL) | 17 | (11) | ||
Lepromatous (LL) | 49 | (32) | ||
Indeterminate leprosy (I) | 11 | (7) | ||
Other forms (Neural) | 6 | (4) | ||
Total#
|
151
|
(100)
| ||
C - Patients with reaction episodea | ||||
RR | 50 | (53) | ||
ENL | 44 | (47) | ||
Total#
|
94
|
(62)
| ||
D - Patients without reaction episodea | ||||
PB | 47 | (82) | ||
MB | 10 | (18) | ||
Total#
|
57
|
(38)
|
Reaction vs No Reaction | |||
---|---|---|---|
Gene | Description | log fold change | p.value* |
CCL2 | C-C Motif Chemokine Ligand 2 | 4.04 | 0.0016 |
PARK | parkinson protein 2, E3 ubiquitin protein ligase | 3.27 | 0.0036 |
ALOX5 | Arachidonate 5-Lipoxygenase | 2.99 | 0.0108 |
TLR7 | Toll Like Receptor 7 | 2.98 | 0.011 |
LRRK2 | Leucine Rich Repeat Kinase 2 | 3.09 | 0.0161 |
IFNB | interferon beta 1 | 2.36 | 0.0228 |
TLR10 | Toll Like Receptor 10 | 3.07 | 0.0236 |
IL18 | Interleukin 18 | 2.34 | 0.0326 |
TLR3 | Toll Like Receptor 3 | 2.74 | 0.0338 |
CLEC5A | C-Type Lectin Domain Containing 5A | 2.81 | 0.0446 |
RR vs No Reaction | |||
CCL2 | C-C Motif Chemokine Ligand 2 | 4.31 | 0.0002 |
TLR7 | Toll Like Receptor 7 | 3.81 | 0.0012 |
PARK | parkinson protein 2, E3 ubiquitin protein ligase | 3.16 | 0.002 |
ALOX5 | Arachidonate 5-Lipoxygenase | 3.32 | 0.0044 |
LRRK2 | Leucine Rich Repeat Kinase 2 | 3.28 | 0.0056 |
IFNB | interferon beta 1 | 2.64 | 0.0104 |
TLR10 | Toll Like Receptor 10 | 3.08 | 0.0122 |
TLR3 | Toll Like Receptor 3 | 3.04 | 0.0122 |
IL18 | Interleukin 18 | 2.65 | 0.014 |
OAS1 | 2′-5′-oligoadenylate synthetase 1 | 2.51 | 0.0376 |
IL15 | Interleukin 15 | 2.42 | 0.0446 |
ENL vs No Reaction | |||
PARK | parkinson protein 2, E3 ubiquitin protein ligase | 2.13 | 0.0436 |
ENL vs RR | |||
TLR7 | Toll Like Receptor 7 | −2.72 | 0.0214 |