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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Urology 1/2015

Xp11.2 translocation renal cell carcinomas in young adults

Zeitschrift:
BMC Urology > Ausgabe 1/2015
Autoren:
Linfeng Xu, Rong Yang, Weidong Gan, Xiancheng Chen, Xuefeng Qiu, Kai Fu, Jin Huang, Guancheng Zhu, Hongqian Guo
Wichtige Hinweise
Linfeng Xu and Rong Yang contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

LX and RY participated in the sequence alignment and drafted the manuscript. XC carried out the immunoassays. KF and GZ participated in the sequence alignment. XQ and JH participated in the design of the study and performed the statistical analysis. WG and HG conceived the study, participated in its design and coordination, and helped draft the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Little is known about the biological behavior of Xp11.2 translocation renal cell carcinomas (RCCs) as few clinical studies have been performed using a large sample size.

Methods

This study included 103 consecutive young adult patients (age ≤ 45 years) with RCC who underwent partial or radical nephrectomy at our institution from 2008 to 2013. Five patients without complete clinical data were excluded. Of the 98 remaining patients, 16 and 82 patients were included in the Xp11.2 translocation and non-Xp11.2 translocation groups, respectively. Clinicopathologic data were collected, including age, gender, tumor size, laterality, symptoms at diagnosis, surgical procedure, pathologic stage, tumor grade, time of recurrence and death.

Results

Xp11.2 translocation RCCs were associated with higher tumor grade and pathologic stage (P < 0.05, Fisher’s exact test). During the median follow-up of 36 months (range: 3–71 months), the number of cancer-related deaths was 4 (4.9 %) and 3 (18.7 %) in the non-Xp11.2 translocation and Xp11.2 translocation groups, respectively. The Kaplan-Meier cancer specific survival curves revealed a significant difference between non-Xp11.2 translocation RCCs and Xp11.2 translocation RCCs in young adults (P = 0.042).

Conclusions

Compared with non-Xp11.2 translocation RCCs, the Xp11.2 translocation RCCs seemingly showed a higher tumor grade and pathologic stage and have similar recurrence-free survival rates but poorer cancer-specific survival rates in young adults.
Literatur
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