Background
Methods
Eligibility criteria
Types of studies design
Types of participants
Types of intervention
Types of control
Types of outcomes
Search strategy
Electronic searches
Additional searches
Studies screening and selection
Data extraction
Risk of bias in individual studies
Synthesis of results
Trial sequential analysis
Sensitivity analysis
Subgroup analysis
Publication bias
Assessment of quality of evidence
Results
General description of overall studies
N | Study ID | Sample(Treatment/Control/Total) | diagnostic criteria | Intervention | Dosage and course duration | Control | Endpoints |
---|---|---|---|---|---|---|---|
1 | Fu KG 2013 [19] | 60/60/120 | NA | Yinzhihuang oral liquid + Phototherapy | 3 ml Po Tid | Phototherapy:Blue light; 8-12 h/d; 5d | Failure of jaundice resolution; Serious adverse events |
2 | Huang J 2013 [20] | 58/56/114 | Practical neonatology | Yinzhihuang + Phototherapy | 5 ml Po Bid | Phototherapy:Blue light; 6-8 h/d; 3d | Failure of jaundice resolution; Total serum bilirubin |
3 | Huang N 2004 [21] | 32/31/63 | NA | Yinzhihuang + Phototherapy | 5 ml Po Bid | Phototherapy | Span of jaundice resolution; Serious adverse events |
4 | Liang LL 2014 [22] | 60/60/120 | NA | Yinzhihuang + Phototherapy | 5 ml Po Bid | Phototherapy:Blue light; 6-8 h/d; 3d | Failure of jaundice resolution; Total serum bilirubin |
5 | Li HF 2013 [23] | 30/30/60 | Chinese Internal Medicine | Yinzhihuang + Phototherapy | 5 ml Po Bid | Phototherapy:Blue light; 16 h/d; 14d | Failure of jaundice resolution; Total serum bilirubin; Time to jaundice resolution; Serious adverse events |
6 | Li Q 2013 [24] | 54/54/108 | NA | Yinzhihuang + Phototherapy | 3 ml Po Tid | Phototherapy:Blue light; 8-12 h/d | Time to jaundice resolution; Total serum bilirubin |
7 | Liu GH 2013 [25] | 25/25/50 | Practical neonatology | Yinzhihuang + Phototherapy | NA | Phototherapy:Blue light; 6d | Failure of jaundice resolution |
8 | Lu J 2014 [26] | 42/42/84 | practical paidonosology | Yinzhihuang + Phototherapy | 5 ml Po Bid | Phototherapy:Blue light; 10 h/d; 7d | Failure of jaundice resolution; Total serum bilirubin; Time to jaundice resolution |
9 | Mu J 2015 [27] | 43/43/86 | Pediatrics | Yinzhihuang + Phototherapy | 5 ml Po Bid | Phototherapy:Blue light; 5-7d | Failure of jaundice resolution; Total serum bilirubin; Serious adverse events |
10 | Qiu J 2014 [28] | 60/60/120 | Pediatrics | Yinzhihuang + Phototherapy | 5 ml Po Tid | Phototherapy:Blue light; 5d | Failure of jaundice resolution; Total serum bilirubin |
11 | Sun ZY 2013 [29] | 100/100/200 | Expert Consensus Documents | Yinzhihuang + Phototherapy | 5 ml Po Bid | Phototherapy:Blue light; 6 h Bid | Total serum bilirubin; Time to jaundice resolution; Serious adverse events |
12 | Wang DF 2014 [30] | 100/100/200 | NA | Yinzhihuang + Phototherapy | 5 ml Po Tid | Phototherapy:Blue light; 12 h/d; 5d | Total serum bilirubin |
13 | Wu Y 2014 [31] | 38/38/76 | Practical neonatology | Yinzhihuang + Phototherapy | 3 ml Po Tid | Phototherapy:Blue light; 8-12 h/d; 3-5d | Failure of jaundice resolution; Total serum bilirubin; Time to jaundice resolution; Serious adverse events |
14 | Xing XW 2012 [32] | 54/54/108 | Practical neonatology | Yinzhihuang + Phototherapy | 3 ml Po Tid | Phototherapy:Blue light; 8-12 h/d; 5d | Failure of jaundice resolution; Total serum bilirubin; Time to jaundice resolution; Serious adverse events |
15 | Yang ZM 2013 [33] | 49/49/98 | NA | Yinzhihuang + Phototherapy | 1 ml/kg Po Tid | Phototherapy:Blue light; 5d | Time to jaundice resolution; Serious adverse events |
16 | Zhao HY 2013 [34] | 75/75/150 | academic conference recommendation | Yinzhihuang + Phototherapy | 3 ml Po Tid | Phototherapy:Blue light; 12 h/d; 7d | Failure of jaundice resolution; Total serum bilirubin |
17 | Clinical Research Collaborative Group of YZH 2011 [35] | 395/409/804 | AAP guideline | Yinzhihuang + Phototherapy | 5 ml Po Bid | Phototherapy:Blue light; 8-12 h/d; 7d | Total serum bilirubin; Serious adverse events |
Assessment of risk of bias
Effects of intervention
Primary outcome
Secondary outcomes
Sensitivity analysis
Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
---|---|---|---|---|---|---|
Assumed risk | Corresponding risk | |||||
Phototherapy | Yinzhihuang oral liquid combined with Phototherapy | |||||
Total serum bilirubin serological tests Follow-up: 0–2 weeks | The mean total serum bilirubin in the intervention groups was 50.25 μmol/l lower (64.01 to 36.50 lower) | 1478 (7 studies) | ⊕⊝⊝⊝ very lowa,b | |||
Time tojaundice resolution Clinical observation Follow-up: 0–2 weeks | The mean time to jaundice resolution in the intervention groups was 2.17 days lower (2.96 to 1.38 lower) | 636 (6 studies) | ⊕⊝⊝⊝ very lowa,c | |||
Failure of jaundice resolution Clinical observation and serological tests Follow-up: 0–2 weeks | Study population | RR 0.21 (0.14 to 0.32) | 1088 (11 studies) | ⊕⊝⊝⊝ very lowa,d | ||
204 per 1000 | 43 per 1000 (29 to 65) | |||||
Medium risk population | ||||||
200 per 1000 | 42 per 1000 (28 to 64) |