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03.07.2018 | Original Article

Zn-containing polymer nanogels promote cervical dentin remineralization

verfasst von: Manuel Toledano, Inmaculada Cabello, Estrella Osorio, Fátima S. Aguilera, Antonio Luis Medina-Castillo, Manuel Toledano-Osorio, Raquel Osorio

Erschienen in: Clinical Oral Investigations | Ausgabe 3/2019

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Abstract

Objective

Nanogels designing for effective treatment of eroded cervical dentin lesions.

Materials and methods

Polymethylmetacrylate-based nanoparticles (NPs) were doxycycline (D), calcium, or zinc loaded. They were applied on eroded cervical dentin. Treated surfaces were characterized morphologically by atomic force and scanning electron microscopy, mechanically probed by a nanoindenter to test nanohardness and Young’s modulus, and chemically analyzed by Raman spectroscopy at 24 h and 7 days of storage. Data were submitted to ANOVA and Student-Newman-Keuls multiple comparisons tests.

Results

Dentin treated with Zn-NPs attained the highest nanomechanical properties, mineralization, and crystallinity among groups. Nanoroughness was lower in Zn-treated surfaces in comparison to dentin treated with undoped gels. Dentin treated with Ca-NPs created the minimal calcification at the surface and showed the lowest Young’s modulus at peritubular dentin. Intertubular dentin appeared remineralized. Dentinal tubules were empty in samples treated with D-NPs, partially occluded in cervical dentin treated with undoped NPs and Ca-NPs, and mineral covered when specimens were treated with Zn-NPs.

Conclusions

Zn-loaded NPs permit functional remineralization of eroded cervical dentin. Based on the tested nanomechanical and chemical properties, Zn-based nanogels are suitable for dentin remineralization.

Clinical relevance

The ability of zinc-loaded nanogels to promote dentin mineralization may offer new strategies for regeneration of eroded cervical dentin and effective treatment of dentin hypersensitivity.

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Titel: Zn-containing polymer nanogels promote cervical dentin remineralization
verfasst von: Manuel Toledano
Inmaculada Cabello
Estrella Osorio
Fátima S. Aguilera
Antonio Luis Medina-Castillo
Manuel Toledano-Osorio
Raquel Osorio
Publikationsdatum: 03.07.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 3/2019
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2548-1

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Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

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