Background
Nowadays, cardiovascular disease (CVD) has become the leading cause of death and disease burden in China and world-wide [
1,
2]. Great efforts have focused on the prevention and treatment of CVD. The Framingham Risk Score has long been proved a strong predictor of developing coronary heart disease (CHD) and cardiovascular events [
3,
4]. And it’s used as a simple tool to evaluate the 10-year risk of CHD to inform the initiating of primary prevention. In China, Gu et al. developed and validated the Chinese atherosclerotic cardiovascular disease (ASCVD) risk equation based on the China-PAR project (Prediction for ASCVD Risk in China) in multiple contemporary Chinese cohorts [
5]. This equation was suitable for China and popular-used for the prediction of ASCVD risk.
Depression has become a worldwide public health problem, especially in women [
6,
7], which contributes to an increased risk of disability [
8] and mortality [
9]. The prevalence of depression is significantly higher in patients with CVD and its presence increases the risk of adverse cardiovascular events [
10]. Furthermore, depression has been proved recently to be an independent risk factor for the incidence of CHD [
11] or even ischemic heart disease [
12]. Therefore, it’s quite an important issue to define those with high possibility of depression so that we could make some strategies to control depressive symptoms and prevent its increased risk of ASCVD.
However, whether the 10-year ASCVD risk is also associated with depressive symptoms or not has never been reported, even though the prevalence of depression was proved to be apparently higher in patients with CVD [
13]. Therefore, the current study was designed to explore the potential correlation between 10-year ASCVD risk and depressive symptoms in a large general Chinese population.
Methods
A multi-stage, random, stratified, cluster-sampling scheme was performed in this study. The details about research design, data collection and measurements have been described previously [
14,
15]. This study was approved by the Ethics Committee of China Medical University, and written consent was obtained from each participant or the proper proxy.
Study population
A total of 14,016 eligible permanent residents ≥35 years of age were invited to participate in the study, and 11,956 agreed and completed the study with a response rate of 85.3%. The exclusion criteria included pregnancy, malignant tumor and severe mental disorders (for example psychosis).
The patient health Questionnaire-9 score
In this study, we adopted the Patient Health Questionnaire-9 (PHQ-9) to evaluate depressive disorder, which was widely used in primary health settings as a screening instrument with good reliability and validity [
16‐
18]. Based on the PHQ-9 tool, the total score would range from 0 to 27, and the severity of depressive disorder was then estimated by the level of PHQ-9 score [
19]. And in this study, we conducted the analyses using PHQ-9 score as continuous scale.
10-year ASCVD risk
The 10-year predicted risk of ASCVD was calculated using the equations suitable for China developed by Gu et al. [
5]. In the equations, besides the major risk factors including age, treated or untreated systolic blood pressure (SBP), total cholesterol (TC), high density lipid cholesterol (HDL-C), current smoking, and diabetes mellitus, 4 additional variables including waist circumference, geographic region, urbanization, and family history of ASCVD were added to the equation.
Definitions
In this study, educational level was divided into three types: primary school or less, middle school, high school or more. Family income was divided into three levels (China Yuan/year): low (≤ 5000), middle (5000–20,000) and high (> 20,000). As recommended by the Working Group on Obesity in China, obesity was defined as a body mass index (BMI) of 28.0 kg/m
2 or higher [
20]. In accordance with the JNC 7 Guidelines [
21], hypertension was defined as a SBP ≥ 140 mmHg and/or a diastolic blood pressure (DBP) ≥ 90 mmHg and/or the use of antihypertensive medications. Diabetes mellitus was defined as a fasting blood glucose (FBG) ≥ 7.0 mmol/L, and/or being on treatment by the World Health Organization criteria [
22]. The National Cholesterol Education Program-Third Adult Treatment Panel criteria was followed for defining dyslipidemia (one of the following elements: TC ≥ 6.21 mmol/L, HDL-C < 1.03 mmol/L, low density lipid cholesterol (LDL-C) ≥ 4.16 mmol/L and triglycerides (TG) ≥ 2.26 mmol/L) [
23].
Statistical analysis
Data were expressed as mean ± standard deviation, percentage, correlation coefficient and β. Differences between groups were compared using two-tailed Student’s t-test, variance analysis or χ2 test as appropriate. The mean levels of PHQ-9 score among different 10-year ASCVD risk categories by sex were calculated and presented. Univariate general lineal model was used to test the interaction of sex and 10-year ASCVD risk category for PHQ-9 score. Pearson correlation analysis was performed to investigate the correlations between 10-year ASCVD risk and PHQ-9 score by sex and different medical conditions. Univariate and multivariate linear regression analyses were both conducted to identify the crude and adjusted linear associations of sex and 10-year ASCVD risk with PHQ-9 score. Further, the potential interaction of sex and 10-year ASCVD risk on PHQ-9 score was tested. All statistical analyses were performed using SPSS 17.0 software (SPSS Inc., Chicago, IL, USA), and a P < 0.05 was considered as statistically significant.
Discussion
The results of this study indicated that the mean level of PHQ-9 score increased with advancing ASCVD risk category in both sexes, and the trend was more apparent in females than males. 10-year ASCVD risk positively correlated with PHQ-9 score with larger regression coefficients in females. Sex had significant effects not only on PHQ-9 score but also on the associations of 10-year ASCVD risk and PHQ-9 score. These findings firstly provide some data about associations between 10-year ASCVD risk and depressive symptoms in a general population.
Recent studies demonstrated that depression was positively associated with both CVD incidence among healthy individuals [
24] and adverse cardiovascular events among patients with established CVD [
25,
26]. Therefore, great efforts were conducted to make clear of the epidemiological characteristics of depression and to make population-based prevention strategies. Accordingly, depression was reported to be quite common among patients with CVD [
27]. Similarly, the prevalence of depression was significantly higher in patients with heart failure [
28], hypertension [
29], diabetes [
30], stroke [
31] than healthy population. Thus, high prevalence of depression was presented among patients with CVD. Now, our data firstly indicated that depressive symptoms was more common in subjects with higher 10-year predicted risk of ASCVD, suggesting that screening and controlling of the potential depressive symptoms were needed among subjects with high risk of ASCVD.
The equation found by Gu et al. has been used widely as a tool suitable for China to assess the incidence risk of ASCVD, which was calculated based on age, treated or untreated SBP, TC, HDL-C, current smoking, diabetes mellitus, waist circumference, geographic region, urbanization and family history of ASCVD [
5]. Previous studies have demonstrated that advancing age [
7,
32], smoking [
33], low HDL-C [
34] and high SBP [
28] were mostly correlated with depression although serum TC and depression might be inversely related [
35]. Therefore, depression and ASCVD have some co-existing risk factors, which might partially explain the positive relationship between 10-year predicted risk and depressive symptoms in our current study. Further, health behaviors, inflammatory processes and heart rate variability might be the potential mechanisms that actually mediated the incidence of ASCVD and depression [
36,
37].
However, some limitations are existing in our study. First, there was only PHQ-9 tool assessing depressive symptoms but no clinical diagnosis of depression by a psychiatrist. Second, the number of participants in some subgroups was relatively small so that an unintentional bias might be brought. Third, the current study was part of NCRCHS, and only rural Chinese subjects ≥35 years of age were included. In addition, covariates in the current study were relatively limited and some other possible covariates might give a bias.
Conclusions
10-year ASCVD risk was positively associated with depressive symptoms in both males and females. And more apparent impacts of 10-year ASCVD risk on PHQ-9 score were observed in females. These findings provided some novel insights into the value of 10-year ASCVD risk in estimating depressive symptoms. Much attention should be paid to depressive disorders among subjects with high 10-year ASCVD risk.
Acknowledgements
We would like to thank Professor Liqiang Zheng for data collection and data management and Professor Zhao Li for support on the project.
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