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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 6/2010

01.06.2010 | Original Article

18F-FDG PET/CT for early detection of embolism and metastatic infection in patients with infective endocarditis

verfasst von: Jelle Van Riet, Evelyn E. Hill, Olivier Gheysens, Steven Dymarkowski, Marie-Christine Herregods, Paul Herijgers, Willy E. Peetermans, Luc Mortelmans

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2010

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Abstract

Purpose

In the acute setting of endocarditis it is very important to assess both the vegetation itself, as well as potential life-threatening complications, in order to decide whether antibiotic therapy will be sufficient or urgent surgery is indicated. A single whole-body scan investigating inflammatory changes could be very helpful to achieve a swift and efficient assessment.

Methods

In this study we assessed whether 18F-FDG can be used to detect and localize peripheral embolism or distant infection. Twenty-four patients with 25 episodes of endocarditis, enrolled between March 2006 and February 2008, underwent 18F-FDG PET/CT imaging on a dedicated PET/CT scanner.

Results

PET/CT imaging revealed a focus of peripheral embolization and/or metastatic infection in 11 episodes (44%). One episode had a positive PET/CT scan result for both embolism and metastatic infection. PET/CT detected seven positive cases (28%) in which there was no clinical suspicion. Valve involvement of endocarditis was seen only in three patients (12%).

Conclusion

PET/CT may be an important diagnostic tool for tracing peripheral embolism and metastatic infection in the acute setting of infective endocarditis, since a PET/CT scan detected a clinically occult focus in nearly one third of episodes.
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Metadaten
Titel
18F-FDG PET/CT for early detection of embolism and metastatic infection in patients with infective endocarditis
verfasst von
Jelle Van Riet
Evelyn E. Hill
Olivier Gheysens
Steven Dymarkowski
Marie-Christine Herregods
Paul Herijgers
Willy E. Peetermans
Luc Mortelmans
Publikationsdatum
01.06.2010
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2010
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-010-1380-x

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