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European Journal of Nuclear Medicine and Molecular Imaging

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06.01.2024 | Original Article

[¹⁸F]SynVesT-1 and [¹⁸F]FDG quantitative PET imaging in the presurgical evaluation of MRI-negative children with focal cortical dysplasia type II

verfasst von: Ling Xiao, Jinhui Yang, Haoyue Zhu, Ming Zhou, Jian Li, Dingyang Liu, Yongxiang Tang, Li Feng, Shuo Hu

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2024

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Abstract

Purpose

MRI-negative children with focal cortical dysplasia type II (FCD II) are one of the most challenging cases in surgical epilepsy management. We aimed to utilize quantitative positron emission tomography (QPET) analysis to complement [¹⁸F]SynVesT-1 and [¹⁸F]FDG PET imaging and facilitate the localization of epileptogenic foci in pediatric MRI-negative FCD II patients.

Methods

We prospectively enrolled 17 MRI-negative children with FCD II who underwent [¹⁸F]SynVesT-1 and [¹⁸F]FDG PET before surgical resection. The QPET scans were analyzed using statistical parametric mapping (SPM) with respect to healthy controls. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of [¹⁸F]SynVesT-1 PET, [¹⁸F]FDG PET, [¹⁸F]SynVesT-1 QPET, and [¹⁸F]FDG QPET in the localization of epileptogenic foci were assessed. Additionally, we developed a multivariate prediction model based on dual trace PET/QPET assessment.

Results

The AUC values of [¹⁸F]FDG PET and [¹⁸F]SynVesT-1 PET were 0.861 (sensitivity = 94.1%, specificity = 78.2%, PPV = 38.1%, NPV = 98.9%) and 0.908 (sensitivity = 82.4%, specificity = 99.2%, PPV = 93.3%, NPV = 97.5%), respectively. [¹⁸F]FDG QPET showed lower sensitivity (76.5%) and NPV (96.6%) but higher specificity (95.0%) and PPV (68.4%) than visual assessment, while [¹⁸F]SynVesT-1 QPET exhibited higher sensitivity (94.1%) and NPV (99.1%) but lower specificity (97.5%) and PPV (84.2%). The multivariate prediction model had the highest AUC value (AUC = 0.996, sensitivity = 100.0%, specificity = 96.6%, PPV = 81.0%, NPV = 100%).

Conclusions

The multivariate prediction model based on [¹⁸F]SynVesT-1 and [¹⁸F]FDG PET/QPET assessments holds promise in noninvasively identifying epileptogenic regions in MRI-negative children with FCD II. Furthermore, the combination of visual assessment and QPET may improve the sensitivity and specificity of diagnostic tests in localizing epileptogenic foci and achieving a preferable surgical outcome in MRI-negative FCD II.

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Titel: [18F]SynVesT-1 and [18F]FDG quantitative PET imaging in the presurgical evaluation of MRI-negative children with focal cortical dysplasia type II
verfasst von: Ling Xiao
Jinhui Yang
Haoyue Zhu
Ming Zhou
Jian Li
Dingyang Liu
Yongxiang Tang
Li Feng
Shuo Hu
Publikationsdatum: 06.01.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2024
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-024-06593-1

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

[¹⁸F]SynVesT-1 and [¹⁸F]FDG quantitative PET imaging in the presurgical evaluation of MRI-negative children with focal cortical dysplasia type II

Abstract

Purpose

Methods

Results

Conclusions

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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