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22.06.2021 | Original Article

A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study

verfasst von: Jonathan J. Bjerre-Bastos, Henning Bay Nielsen, Jeppe R. Andersen, Morten Karsdal, Mikael Boesen, Abigail L. Mackey, Inger Byrjalsen, Christian S. Thudium, Asger R. Bihlet

Erschienen in: European Journal of Applied Physiology | Ausgabe 10/2021

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Abstract

Purpose

To investigate acute changes in biochemical markers of bone and cartilage turnover in response to moderate intensity exercise with and without joint impact in healthy human subjects.

Methods

A randomized, cross-over, exploratory, clinical study was conducted. Twenty healthy subjects with no history of joint trauma completed 30 min interventions of standardized moderate intensity cycling and running as well as a resting intervention 1 week apart. Blood samples were taken immediately before, four times after exercise and again the next day. Urine was sampled, before, after and the next day. On the day of rest, samples were taken at timepoints similar to the days of exercise. Markers of type I (CTX-I), II (C2M, CTX-II) and VI (C6M) collagen degradation, cartilage oligomeric matrix protein (COMP) and procollagen C-2 (PRO-C2) was measured. Trial registration number: NCT04542655, 02 September 2020, retrospectively registered.

Results

CTX-I was different from cycling (4.2%, 95%CI: 0.4–8.0%, p = 0.03) and resting (6.8%, 95%CI: 2.9–10.7%, p = 0.001) after running and the mean change in COMP was different from cycling (10.3%, 95%CI: 1.1–19.5%, p = 0.03), but not from resting (8.6%, 95%CI: − 0.7–17.8%, p = 0.07) after running. Overall, changes in other biomarkers were not different between interventions.

Conclusion

In this exploratory study, running, but not cycling, at a moderate intensity and duration induced acute changes in biomarkers of bone and cartilage extra-cellular matrix turnover.

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Titel: A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study
verfasst von: Jonathan J. Bjerre-Bastos
Henning Bay Nielsen
Jeppe R. Andersen
Morten Karsdal
Mikael Boesen
Abigail L. Mackey
Inger Byrjalsen
Christian S. Thudium
Asger R. Bihlet
Publikationsdatum: 22.06.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 10/2021
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-021-04751-z

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Abstract

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