Background
Methods
Data collection
Microarray data analysis
GO annotations and pathway analysis
Results and Discussion
Global outlook by time-course analysis
FC ≥ 2.0 | 1 v 2 | 2 v 4 | 4 v 8 | 8 v M | M v B | |
---|---|---|---|---|---|---|
Mouse
|
down
| 1867 | 1242 | 1233 | 819 | 1794 |
up
| 2449 | 691 | 1368 | 2581 | 140 | |
Human
|
down
| 10 | 375 | 2180 | 2423 | 1979 |
up
| 152 | 30 | 5098 | 1768 | 1532 |
Analysis of individual genes
Significantly related GO terms and pathways
GO | p value | |
---|---|---|
1 v 2
(16)
| GO:0044237~cellular metabolic process | 1.29E-36 |
GO:0044238~primary metabolic process | 1.10E-35 | |
GO:0043170~macromolecule metabolic process | 2.51E-31 | |
GO:0006412~translation | 1.47E-24 | |
GO:0006396~RNA processing | 7.26E-17 | |
GO:0009058~biosynthetic process | 1.11E-15 | |
GO:0016043~cellular component organization and biogenesis | 4.25E-10 | |
GO:0033036~macromolecule localization | 9.42E-10 | |
GO:0045184~establishment of protein localization | 2.45E-08 | |
GO:0051236~establishment of RNA localization | 7.03E-08 | |
GO:0051649~establishment of cellular localization | 1.81E-07 | |
GO:0051641~cellular localization | 1.94E-07 | |
GO:0009719~response to endogenous stimulus | 3.33E-07 | |
GO:0007049~cell cycle | 4.72E-06 | |
GO:0007059~chromosome segregation | 2.76E-05 | |
GO:0022402~cell cycle process | 2.74E-04 | |
GO:0051301~cell division | 2.08E-03 | |
2 v 4
(13)
| GO:0006412~translation | 3.45E-25 |
GO:0044237~cellular metabolic process | 2.41E-23 | |
GO:0044238~primary metabolic process | 3.32E-23 | |
GO:0043170~macromolecule metabolic process | 2.39E-20 | |
GO:0009058~biosynthetic process | 3.38E-15 | |
GO:0006396~RNA processing | 2.37E-09 | |
GO:0045184~establishment of protein localization | 4.15E-06 | |
GO:0033036~macromolecule localization | 5.72E-06 | |
GO:0009056~catabolic process | 2.71E-05 | |
GO:0016043~cellular component organization and biogenesis | 7.18E-05 | |
GO:0051236~establishment of RNA localization | 1.14E-03 | |
GO:0051641~cellular localization | 1.21E-03 | |
GO:0051649~establishment of cellular localization | 1.55E-03 | |
4 v 8
(18)
| GO:0044238~primary metabolic process | 1.36E-12 |
GO:0044237~cellular metabolic process | 6.67E-11 | |
GO:0043170~macromolecule metabolic process | 1.09E-10 | |
GO:0016043~cellular component organization and biogenesis | 1.02E-08 | |
GO:0051301~cell division | 3.26E-08 | |
GO:0051641~cellular localization | 9.22E-08 | |
GO:0051649~establishment of cellular localization | 2.26E-07 | |
GO:0009058~biosynthetic process | 2.41E-07 | |
GO:0006412~translation | 6.46E-06 | |
GO:0006396~RNA processing | 6.77E-06 | |
GO:0007049~cell cycle | 6.78E-06 | |
GO:0033036~macromolecule localization | 8.58E-06 | |
GO:0045184~establishment of protein localization | 2.35E-05 | |
GO:0022402~cell cycle process | 2.49E-05 | |
GO:0009719~response to endogenous stimulus | 1.82E-03 | |
GO:0007059~chromosome segregation | 3.13E-03 | |
GO:0009056~catabolic process | 3.62E-03 | |
GO:0065009~regulation of a molecular function | 7.05E-03 | |
8 v M(17)
| GO:0044238~primary metabolic process | 1.92E-32 |
GO:0044237~cellular metabolic process | 1.80E-31 | |
GO:0006396~RNA processing | 4.57E-25 | |
GO:0006412~translation | 2.48E-24 | |
GO:0043170~macromolecule metabolic process | 2.54E-21 | |
GO:0009058~biosynthetic process | 5.20E-18 | |
GO:0016043~cellular component organization and biogenesis | 1.61E-11 | |
GO:0033036~macromolecule localization | 2.59E-09 | |
GO:0045184~establishment of protein localization | 8.07E-09 | |
GO:0051236~establishment of RNA localization | 1.36E-08 | |
GO:0051649~establishment of cellular localization | 5.39E-08 | |
GO:0051641~cellular localization | 6.48E-08 | |
GO:0051301~cell division | 1.12E-06 | |
GO:0009056~catabolic process | 1.25E-04 | |
GO:0007049~cell cycle | 2.38E-04 | |
GO:0009719~response to endogenous stimulus | 4.92E-04 | |
GO:0022402~cell cycle process | 2.11E-03 | |
M v B (15)
| GO:0006412~translation | 3.01E-21 |
GO:0009058~biosynthetic process | 9.93E-21 | |
GO:0044237~cellular metabolic process | 4.03E-15 | |
GO:0006396~RNA processing | 4.06E-13 | |
GO:0044238~primary metabolic process | 8.43E-13 | |
GO:0033036~macromolecule localization | 3.53E-12 | |
GO:0016043~cellular component organization and biogenesis | 9.61E-10 | |
GO:0045184~establishment of protein localization | 1.35E-09 | |
GO:0043170~macromolecule metabolic process | 1.03E-08 | |
GO:0051641~cellular localization | 5.79E-08 | |
GO:0051649~establishment of cellular localization | 2.05E-07 | |
GO:0006091~generation of precursor metabolites and energy | 1.36E-06 | |
GO:0051236~establishment of RNA localization | 2.51E-05 | |
GO:0009056~catabolic process | 9.86E-05 | |
GO:0051301~cell division | 1.37E-03 |
GO | p value | |
---|---|---|
1 v 2
(4)
| GO:0051301~cell division | 1.92E-03 |
GO:0044237~cellular metabolic process | 3.40E-03 | |
GO:0006396~RNA processing | 6.67E-03 | |
GO:0022402~cell cycle process | 8.89E-03 | |
2 v 4
(4)
| GO:0044238~primary metabolic process | 1.67E-03 |
GO:0044237~cellular metabolic process | 2.92E-03 | |
GO:0016265~death | 5.13E-03 | |
GO:0006396~RNA processing | 8.17E-03 | |
4 v 8
(23)
| GO:0043170~macromolecule metabolic process | 2.72E-45 |
GO:0044238~primary metabolic process | 1.47E-38 | |
GO:0044237~cellular metabolic process | 2.95E-34 | |
GO:0006396~RNA processing | 7.68E-27 | |
GO:0016043~cellular component organization and biogenesis | 1.00E-25 | |
GO:0019222~regulation of metabolic process | 2.41E-18 | |
GO:0050794~regulation of cellular process | 3.30E-18 | |
GO:0010468~regulation of gene expression | 1.21E-17 | |
GO:0006350~transcription | 2.63E-17 | |
GO:0007049~cell cycle | 7.90E-16 | |
GO:0051301~cell division | 4.09E-15 | |
GO:0033036~macromolecule localization | 6.39E-14 | |
GO:0050789~regulation of biological process | 1.18E-12 | |
GO:0045184~establishment of protein localization | 1.36E-11 | |
GO:0051236~establishment of RNA localization | 5.45E-11 | |
GO:0022402~cell cycle process | 5.56E-10 | |
GO:0051649~establishment of cellular localization | 1.10E-07 | |
GO:0007059~chromosome segregation | 2.18E-07 | |
GO:0051641~cellular localization | 5.55E-07 | |
GO:0006412~translation | 4.44E-05 | |
GO:0051656~establishment of organelle localization | 5.55E-04 | |
GO:0006376~mRNA splice site selection | 1.24E-03 | |
GO:0016265~death | 5.38E-03 | |
8 v M
(21)
| GO:0044238~primary metabolic process | 6.11E-25 |
GO:0044237~cellular metabolic process | 2.20E-24 | |
GO:0043170~macromolecule metabolic process | 4.54E-19 | |
GO:0016043~cellular component organization and biogenesis | 3.52E-10 | |
GO:0006412~translation | 5.04E-08 | |
GO:0006396~RNA processing | 1.20E-06 | |
GO:0051236~establishment of RNA localization | 2.12E-06 | |
GO:0007049~cell cycle | 4.24E-06 | |
GO:0009058~biosynthetic process | 7.48E-06 | |
GO:0009719~response to endogenous stimulus | 7.65E-06 | |
GO:0022402~cell cycle process | 1.01E-05 | |
GO:0033036~macromolecule localization | 1.21E-05 | |
GO:0045184~establishment of protein localization | 6.87E-05 | |
GO:0009056~catabolic process | 7.37E-04 | |
GO:0007059~chromosome segregation | 7.54E-04 | |
GO:0051301~cell division | 1.01E-03 | |
GO:0051649~establishment of cellular localization | 3.81E-03 | |
GO:0019222~regulation of metabolic process | 3.92E-03 | |
GO:0019748~secondary metabolic process | 3.97E-03 | |
GO:0051641~cellular localization | 4.23E-03 | |
GO:0050794~regulation of cellular process | 5.35E-03 | |
M v B
(21)
| GO:0044238~primary metabolic process | 6.38E-14 |
GO:0044237~cellular metabolic process | 1.65E-13 | |
GO:0043170~macromolecule metabolic process | 5.25E-09 | |
GO:0016043~cellular component organization and biogenesis | 6.25E-08 | |
GO:0033036~macromolecule localization | 2.08E-07 | |
GO:0050794~regulation of cellular process | 7.93E-07 | |
GO:0045184~establishment of protein localization | 4.81E-06 | |
GO:0050789~regulation of biological process | 6.99E-06 | |
GO:0051641~cellular localization | 3.08E-05 | |
GO:0051649~establishment of cellular localization | 6.51E-05 | |
GO:0010468~regulation of gene expression | 1.68E-04 | |
GO:0019222~regulation of metabolic process | 2.30E-04 | |
GO:0016265~death | 4.69E-04 | |
GO:0006396~RNA processing | 5.29E-04 | |
GO:0007049~cell cycle | 6.10E-04 | |
GO:0006350~transcription | 1.46E-03 | |
GO:0022402~cell cycle process | 1.71E-03 | |
GO:0051301~cell division | 5.49E-03 | |
GO:0009058~biosynthetic process | 5.64E-03 | |
GO:0048468~cell development | 6.89E-03 | |
GO:0009056~catabolic process | 9.26E-03 |
pathways | p value | |
---|---|---|
1 v 2
(10)
| mmu03010:Ribosome | 1.25E-40 |
mmu04120:Ubiquitin mediated proteolysis | 4.56E-08 | |
mmu00240:Pyrimidine metabolism | 6.90E-06 | |
mmu00230:Purine metabolism | 8.55E-05 | |
mmu04110:Cell cycle | 1.25E-04 | |
mmu03050:Proteasome | 2.07E-04 | |
mmu03020:RNA polymerase | 3.18E-03 | |
mmu04115:p53 signaling pathway | 3.71E-03 | |
mmu00190:Oxidative phosphorylation | 3.87E-03 | |
mmu03030:DNA polymerase | 7.14E-03 | |
2 v 4
(7)
| mmu03010:Ribosome | 2.02E-39 |
mmu03050:Proteasome | 3.67E-09 | |
mmu04110:Cell cycle | 6.60E-04 | |
mmu00040:Pentose and glucuronate interconversions | 1.93E-03 | |
mmu00190:Oxidative phosphorylation | 3.33E-03 | |
mmu00230:Purine metabolism | 4.03E-03 | |
mmu00500:Starch and sucrose metabolism | 9.65E-03 | |
4 v 8
(5)
| mmu03010:Ribosome | 2.50E-08 |
mmu03050:Proteasome | 4.84E-07 | |
mmu00190:Oxidative phosphorylation | 2.41E-05 | |
mmu04120:Ubiquitin mediated proteolysis | 2.63E-03 | |
mmu00020:Citrate cycle (TCA cycle) | 3.94E-03 | |
8 v M
(10)
| mmu03010:Ribosome | 1.01E-25 |
mmu03050:Proteasome | 2.73E-13 | |
mmu00240:Pyrimidine metabolism | 2.26E-10 | |
mmu03020:RNA polymerase | 1.23E-08 | |
mmu04110:Cell cycle | 1.97E-07 | |
mmu00230:Purine metabolism | 1.36E-05 | |
mmu00500:Starch and sucrose metabolism | 4.42E-04 | |
mmu04120:Ubiquitin mediated proteolysis | 6.82E-04 | |
mmu00040:Pentose and glucuronate interconversions | 8.00E-04 | |
mmu00190:Oxidative phosphorylation | 4.44E-03 | |
M v B
(9)
| mmu03010:Ribosome | 4.82E-19 |
mmu00190:Oxidative phosphorylation | 2.53E-16 | |
mmu03050:Proteasome | 1.17E-09 | |
mmu00280:Valine, leucine and isoleucine degradation | 6.28E-06 | |
mmu00020:Citrate cycle (TCA cycle) | 1.21E-05 | |
mmu04110:Cell cycle | 5.17E-04 | |
mmu00100:Biosynthesis of steroids | 3.50E-03 | |
mmu00071:Fatty acid metabolism | 3.50E-03 | |
mmu00281:Geraniol degradation | 4.47E-03 |
pathways | p value | |
---|---|---|
1 v 2
(0)
| none | none |
2 v 4
(3)
| hsa04540:Gap junction | 2.29E-03 |
hsa00100:Biosynthesis of steroids | 2.84E-03 | |
hsa05060:Prion disease | 4.75E-03 | |
4 v 8
(8)
| hsa04110:Cell cycle | 3.37E-09 |
hsa04120:Ubiquitin mediated proteolysis | 1.44E-07 | |
hsa04520:Adherens junction | 5.58E-06 | |
hsa04115:p53 signaling pathway | 2.87E-04 | |
hsa03022:Basal transcription factors | 8.31E-04 | |
hsa00230:Purine metabolism | 4.87E-03 | |
hsa05215:Prostate cancer | 4.99E-03 | |
hsa00970:Aminoacyl-tRNA biosynthesis | 8.41E-03 | |
8 v M
(6)
| hsa04120:Ubiquitin mediated proteolysis | 9.93E-05 |
hsa04110:Cell cycle | 1.58E-04 | |
hsa05131: Eenteropathogenic E. coli (EPEC) infection | 3.82E-03 | |
hsa05130: Enterohemorrhagic E. coli (EHEC) infection | 3.82E-03 | |
hsa04115:p53 signaling pathway | 3.93E-03 | |
hsa05221:Acute myeloid leukemia | 7.63E-03 | |
M v B
(11)
| hsa00100:Biosynthesis of steroids | 2.26E-06 |
hsa05131: Eenteropathogenic E. coli (EPEC) infection | 5.82E-05 | |
hsa05130: Enterohemorrhagic E. coli (EHEC) infection | 5.82E-05 | |
hsa04120:Ubiquitin mediated proteolysis | 1.78E-04 | |
hsa00251:Glutamate metabolism | 3.03E-04 | |
hsa04520:Adherens junction | 7.05E-04 | |
hsa00071:Fatty acid metabolism | 2.75E-03 | |
hsa05110:Cholera - Infection | 2.93E-03 | |
hsa00280:Valine, leucine and isoleucine degradation | 6.04E-03 | |
hsa05211:Renal cell carcinoma | 6.26E-03 | |
hsa00900:Terpenoid biosynthesis | 7.14E-03 |