Anzeige
Erschienen in:
15.03.2019 | Original Contribution
A Comparative Study Evaluating the Incidence of Colorectal Neoplasia(s) in Candidates for Bariatric Surgery by Screening Colonoscopy, 40–49 Versus 50–65 Years Old: a Preliminary Study
Erschienen in: Obesity Surgery | Ausgabe 8/2019
Einloggen, um Zugang zu erhaltenAbstract
Introduction
Obesity and metabolic syndrome (MetS) are associated with colorectal neoplasia (CRN) and carcinoma (CRC). Whether such subjects must undergo screening colonoscopy (SC) earlier, is unknown. Incidences of CRNs in 40–49- versus 50–65-year-old bariatric patients were compared by SC. No prospective data on SC is available in morbidly obese/MetS.
Material and Methods
Surgical weight loss candidates over 39 years of age, asymptomatic, and average-risk for CRC offered SC. Those giving written informed consent were enrolled. Colonoscopies were done by the same surgeon. Smoking/drinking history, fasting blood glucose (FBG), insulin, C-peptide, triglyceride, high density lipoprotein, vitamin D, HbA1c, and insulin resistance parameters were recorded. CRN rate and the distribution of variables in patients 40–49 years of age were compared with 50–65. Student’s t and Chi-square tests were used as appropriate. P < 0.05 was regarded as statistically significant.
Results
Among 168 SCs, 47 had CRNs (27.9%). Including carcinoma, 15 had an advanced CRN (aCRN) (8.9% aCRN and 0.6% CRC). CRN rate was 35.6% in ≥ 50 years old whereas 22.1% in 40–49 (p = 0.053). aCRN rates (8.4% in 40–49 versus 9.6% in 50–65) were similar (p = 0.792). Metabolic parameters and smoking-drinking history were equally distributed between the groups except FBG and HbA1c as their mean levels were slightly higher in the 50–65 age group (p < 0.05).
Conclusions
Presented results warrant routine SC in the 40–49-year-old morbidly obese and/or MetS patient population with average risk, and in aged > 50, it certainly must be enforced and included in the preoperative check-list if not done before.