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International Urology and Nephrology

Erschienen in:

01.03.2011 | Nephrology – Original Paper

A comparison of different methods for the determination of glomerular filtration rate in elderly patients with chronic renal failure

verfasst von: Beyza Macunluoğlu, İbrahim Gökçe, Aydın Atakan, Münir Demirci, Elif Arı, Ahmet Topuzoğlu, Ali Borazan

Erschienen in: International Urology and Nephrology | Ausgabe 1/2011

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Abstract

Objective

The aim of the present study was to asses the accuracy of prediction equations in elderly patients with advanced renal disease (ARD).

Patients and methods

Twenty-three elderly patients (>60 years) with chronic kidney disease (CKD) stages 3–5 underwent technetium-99 m-diethylenetriaminepentaacetic acid (Tc-99m-DTPA) radionuclide measurement of glomerular filtration rate (GFR). To predict GFR, estimation formulas [Cockcroft-Gault (CG), 6-variable Modification of Diet in Renal Disease (6-var-MDRD) and the corrected 24-hour creatinine clearance (24-h CCL) method] were used. Estimates of bias and precision were obtained to compare prediction equations of GFR with standard radionuclide measurement.

Results

In the present study, all the prediction equations overestimated the GFR measured with the radionuclide method. Six-var-MDRD and 24-h CCL methods correlated better with standard radionuclide measurements compared to the CG formula (Rc of 0.53 and 0.50 vs. 0.41, respectively) as for GFR prediction, but they were still insufficiently accurate.

Conclusion

Glomerular filtration rate prediction equations correlate poorly with standard radionuclide measurements and their use may lead to late initialization of renal replacement therapy in elderly patients with ARD. Therefore, measurement by standard radionuclide method (Tc-99m-DTPA) is recommended to accurately assess GFR in elderly patients with ARD.

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Titel: A comparison of different methods for the determination of glomerular filtration rate in elderly patients with chronic renal failure
verfasst von: Beyza Macunluoğlu
İbrahim Gökçe
Aydın Atakan
Münir Demirci
Elif Arı
Ahmet Topuzoğlu
Ali Borazan
Publikationsdatum: 01.03.2011
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 1/2011
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-010-9846-0

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A comparison of different methods for the determination of glomerular filtration rate in elderly patients with chronic renal failure