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01.01.2024 | Research

A comprehensive analysis of the association between anemia and systemic inflammation in older patients with cancer

verfasst von: Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Min Yang, Han-Ping Shi, Ming-Hua Cong

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2024

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Abstract

Purpose

Our study aimed to comprehensively analyze the association between anemia and systemic inflammation in older patients with cancer.

Methods

This multicenter prospective cohort study included 4955 older patients with cancer between 2013 and 2020. Logistic regression analysis was performed to investigate risk factors of anemia, reporting odds ratios (ORs), and 95% confidence intervals (CIs). Comprehensive survival analyses, including Kaplan–Meier curve, Cox proportional risk model, and subgroup analysis, were performed.

Results

The participants’ median age was 70.0 (interquartile range [IQR]=67.0–74.0) years, with 3293 (66.5%) males and 1662 (33.5%) females. There were 1717 (34.7%) older patients with cancer diagnosed with anemia. High neutrophil-to-lymphocyte ratio (NLR) was an independent risk factor associated with anemia (adjusted OR=1.97, 95%CI=1.73–2.24, P<0.001). In older patients with cancer and different anemia levels, the median overall survival was significantly shorter in those with a high NLR. In multivariate Cox analysis, high NLR served as a negative factor, independently affecting survival. The anemia-inflammation prognostic grading system showed a significant survival discriminative performance in older patients with cancer. After adjusting for confounders, high grades were independent risk factors for survival (grade 2: hazard ratio [HR] = 1.38, 95%CI = 1.26–1.52, P<0.001; grade 3: HR=1.82 95%CI = 1.59–2.09, P<0.001). This grading system was beneficial in determining survival in patients with lung, digestive tract, and urogenital cancers.

Conclusions

Increased systemic inflammation is an independent risk factor for anemia. A high inflammatory status is also associated with poor survival in older cancer patients at different anemia levels. The anemia-inflammation grading system is beneficial for determining the prognosis in older patients with cancer.

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Titel: A comprehensive analysis of the association between anemia and systemic inflammation in older patients with cancer
verfasst von: Xi Zhang
Jia-Xin Huang
Meng Tang
Qi Zhang
Li Deng
Chun-Hua Song
Wei Li
Min Yang
Han-Ping Shi
Ming-Hua Cong
Publikationsdatum: 01.01.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 1/2024
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-023-08247-8

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

A comprehensive analysis of the association between anemia and systemic inflammation in older patients with cancer