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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Emilia V Noormahomed, Marika Orlov, Virgilio do Rosario, Brett W Petersen, Carly Guthrie, Roberto Badaro, Robert T Schooley
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-252) contains supplementary material, which is available to authorized users.

Competing interests

Dr. Schooley is a member of the Scientific Advisory Board of Gilead Sciences.

Authors’ contributions

EVN and RTS designed, obtained research funding and were responsible for the overall conduct of the study. RB and VR contributed to data analysis and preparation of the manuscript. BP, CG and MO contributed to study design and analysis and were responsible for sample collection and conducted the PCR assays. All authors read and approved the final manuscript.

Abstract

Background

Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual.

Methods

A cross-sectional study among HIV-1 infected and uninfected populations was recruited in Mocuba and Maputo, Mozambique to determine the prevalence of sub-clinical malarial parasitaemia using light microscopy and a nested PCR assay.

Results

The prevalence of sub-clinical P. falciparum parasitaemia was low in Maputo, whether determined by microscopy (0.4%) or PCR (1.9%), but substantially higher in Mocuba (7.6 and 14.7%, respectively). Nested PCR detected nearly 70% more cases of sub-clinical parasitaemia than microscopy, but differences occur by locality. HIV-1 infected persons were more likely to be sub-clinically parasitaemic than HIV-1 uninfected individuals recruited from the same geographic areas. Trimethoprim-sulphamethoxazole use did not substantially reduce sub-clinical parasitaemia.

Conclusions

Dried blood spots are a convenient and sensitive technique for detecting sub-clinical infection with P. falciparum by nested PCR. Prevalence of P. falciparum is substantially lower in Maputo where malaria control programmes have been more active than in the rural town of Mocuba. In Mocuba, among those presenting for HIV-1 counseling and testing, the prevalence of P. falciparum is substantially higher in those who test positive for HIV-1 than those without HIV-1 infection. The clinical implications of sub-clinical P. falciparum infection among HIV-1 infected persons warrant additional study.
Zusatzmaterial
Authors’ original file for figure 1
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Authors’ original file for figure 2
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Authors’ original file for figure 5
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Literatur
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