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Erschienen in:
01.05.2008 | Brief Communication
A dose–response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy
Erschienen in: Child's Nervous System | Ausgabe 5/2008
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Objectives
To observe the dose–response relationship of intramuscular injections of botulinum toxin A (BTX-A) in the spastic cerebral palsy.
Methods
One hundred fifty cases (age between 2 and 12 years) were randomly divided into three groups. The patients were injected with different dose of BTX-A. The movement function was evaluated with modified Ashworth scale (MAS) and physician's rating scale (PRS) at entry and 1 month after injection. The analyses were conducted with one-way analysis of variance and χ
2 test.
Results
The evaluation of MAS and PRS revealed a significant increase of movement function. No statistically significant differences of the side effects among three groups could be demonstrated.
Conclusions
The study suggested that the movement function was more significantly improved with relatively higher dose of BTX-A, which was safe and effective.