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12.10.2016 | Original Contribution

A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats

verfasst von: Eunice Molinar-Toribio, Elisabet Fuguet, Sara Ramos-Romero, Núria Taltavull, Lucía Méndez, M. Rosa Nogués, Isabel Medina, Josep Lluís Torres, Jara Pérez-Jiménez

Erschienen in: European Journal of Nutrition | Ausgabe 1/2018

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Abstract

Purpose

Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE).

Methods

Adult female Wistar–Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC–MS/MS analysis.

Results

A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed.

Conclusions

These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes.

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Titel: A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats
verfasst von: Eunice Molinar-Toribio
Elisabet Fuguet
Sara Ramos-Romero
Núria Taltavull
Lucía Méndez
M. Rosa Nogués
Isabel Medina
Josep Lluís Torres
Jara Pérez-Jiménez
Publikationsdatum: 12.10.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 1/2018
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1323-9

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