Introduction
Material and methods
Pleurapump® system
Study animals
Surgical procedures
Experimental procedures
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In the first two animals, the frequency and amplitude of intermittent positive-pressure ventilation (IPPV) were varied to mimic normal, rapid and slow breathing
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Normal respiratory rate (15 breath/min) with a tidal volume of 270 ml/breath
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Respiration with high respiratory rate (28 breath/min) and tidal volume of 140 ml/breath
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Respiration with low respiratory rate (10 breath/min) and tidal volume of 400 ml/breath
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In the second two animals, experiments were performed under spontaneous breathing with close monitoring
Statistical analysis
Results
Pump functionality
Animal | Ventilation | Number of pump cycles | Total volume transported (ml) | Number of pump cycle errors | |||
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Attempted | Successful | Insufficient transport time | Insufficient fluid in cavity | Bladder pressure too high | |||
1 | Ventilated | 24 | 33 | 703.4 | 6 | 3 | 0 |
2 | Ventilated | 0 | 34 | 0 | 0 | 0 | 0 |
3 | Spontaneous breathing | 58 | 88 | 1502.8 | 0 | 18 | 12 |
4 | Spontaneous breathing | 59 | 71 | 1507.5 | 2 | 10 | 0 |